Chemosphere, Journal Year: 2024, Volume and Issue: 367, P. 143606 - 143606
Published: Oct. 22, 2024
Language: Английский
Chemosphere, Journal Year: 2024, Volume and Issue: 367, P. 143606 - 143606
Published: Oct. 22, 2024
Language: Английский
Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 13, 2025
The deleterious health implications of perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely recognized. Females, in contrast to males, exhibit unique pathways for PFAS exposure excretion, leading complex outcomes. status females is largely influenced by hormone-related processes. have been reported be associated with various aspects female health, including reproductive system disorders pregnancy-related diseases. In this article, we provide insights into the correlations between female-prevalent Current epidemiological toxicological evidence has demonstrated that adverse effects on primarily attributed disruption hypothalamic-pituitary-gonadal (HPG) axis hormonal homeostasis. However, these findings do not sufficiently elucidate intricate associations specific Furthermore, autoimmune disorders, another category more prevalent women compared men, require additional investigation. Immune biomarkers pertinent observed exposure, although insufficient substantiate relations. Further thorough exploration encompassing studies essential elucidating inherent influence human pathologies. Additionally, comprehensive investigations issues beyond their functions essential.
Language: Английский
Citations
1Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)
Published: Oct. 29, 2024
The integration of immunotoxicity data into chemical risk assessment paradigms is essential for comprehensively evaluating the potential health hazards posed by exposures. This review provides a comprehensive overview methodologies, challenges, and future directions integrating frameworks. It discusses fundamental principles immunotoxicology its relevance to assessment, highlighting critical roles immune system in defense against harmful agents. Next, we explore traditional frameworks, including exposure hazard identification, dose–response characterization, need incorporating endpoints enhance characterization estimation. Subsequently, delve modelling immunotoxicity, elucidating principles, methods, case studies illustrating relationships extrapolation from animal humans. Furthermore, discuss focusing on identification immunotoxic hazards, evaluation endpoints, utilization immunological biomarkers assessment. We then examine cumulative strategies, presenting conceptual framework assessing risks multiple exposures methods different chemicals. Lastly, emerging trends high-throughput screening assays, omics technologies, computational modelling, alternative testing along with regulatory implications research needs. valuable insights researchers, regulators, stakeholders involved public protection, facilitating development evidence-based strategies safeguarding human associated
Language: Английский
Citations
8Chemosphere, Journal Year: 2025, Volume and Issue: 372, P. 144119 - 144119
Published: Jan. 18, 2025
Language: Английский
Citations
0Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 27, 2025
Abstract Exposure to per- and polyfluorinated substances (PFAS) hydroxylated polychlorinated biphenyls (OH-PCBs) is associated with adverse human health effects, including immunosuppression. It unknown if these can affect the course of autoimmune diseases. This study was based on 907 individuals multiple sclerosis (MS) matched controls, where MS cases were followed longitudinally using Swedish register. We demonstrate sex- disease-specific differences in serum PFAS concentrations between controls. Moreover, two OH-PCBs (4-OH-CB187 3-OH-CB153) are an increased risk developing sclerosis, regardless sex immigration status. With a clinical follow-up time up 18 years, increase perfluorooctanoic acid (PFOA), perfluorooctane sulfonic (PFOS), perfluorodecanoic (PFDA) decreases confirmed disability worsening both sexes, as well perfluoroheptanesulfonic (PFHpS) perfluorononanoic (PFNA), only males MS. These results show previously associations MS, inverse exposure
Language: Английский
Citations
0Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118087 - 118087
Published: March 30, 2025
Language: Английский
Citations
0Environment International, Journal Year: 2025, Volume and Issue: 196, P. 109288 - 109288
Published: Jan. 16, 2025
Language: Английский
Citations
0Cytokine, Journal Year: 2024, Volume and Issue: 184, P. 156753 - 156753
Published: Sept. 18, 2024
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that have been linked to a number of health outcomes, including those related immune dysfunction. However, there limited numbers epidemiological-based studies directly examine the association between PFAS exposure responses.
Language: Английский
Citations
3The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: unknown, P. 106641 - 106641
Published: Nov. 1, 2024
Language: Английский
Citations
1Chemosphere, Journal Year: 2024, Volume and Issue: 367, P. 143606 - 143606
Published: Oct. 22, 2024
Language: Английский
Citations
0