Antimicrobial Susceptibility Patterns and Antimicrobial Therapy of Infections Caused by Elizabethkingia Species DOI Creative Commons
Chienhsiu Huang

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1990 - 1990

Published: Dec. 2, 2024

Background and Objectives: Elizabethkingia species have become significant sources of infections acquired in hospital settings are commonly linked to high mortality rates. Antimicrobial resistance can be influenced by species, geographical location, antimicrobial susceptibility testing methods, the time bacterial isolation. There distinct patterns among investigation into potential antibiotic variations is beneficial. no guidance on treatment literature. Consequently, purpose this review was elaborate through a scoping existing studies antibiograms illness caused species. Materials Methods: A comprehensive literature search PubMed Web Science between 1 January 2000 30 April 2024 identified all studies, including those that examined therapy I considered for which only broth microdilution methods agar dilution were used. Results: The sensitivity levels meningoseptica piperacillin–tazobactam (5–100%), ciprofloxacin (0–43.4%), levofloxacin (30–81.8%), trimethoprim–sulfamethoxazole (0–100%), tigecycline (15–100%), minocycline (60–100%), rifampicin (94–100%) varied. anophelis (3.3–93.3%), (1–75%), (12–100%), (1.02–96.7%), (0–52.2%), (97.5–100%), (20.5–96%) miricola (41.6–94.0%), (14–75%), (77.0–100%), (18.0–100%), (50%), (100%), (66–85.7%) Conclusions: majority isolates susceptible rifampin. This issue requires professional knowledge integration recommendations.

Language: Английский

Rare or Unusual Non-Fermenting Gram-Negative Bacteria: Therapeutic Approach and Antibiotic Treatment Options DOI Creative Commons
Nicholas Geremia, Andrea Marıno, Andrea De Vito

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 306 - 306

Published: March 16, 2025

Non-fermenting Gram-negative bacteria (NFGNB) are a heterogeneous group of opportunistic pathogens increasingly associated with healthcare-associated infections. While Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia well known, rarer species such as Burkholderia cepacia complex, Achromobacter spp., Chryseobacterium Elizabethkingia Ralstonia others pose emerging therapeutic challenges. Their intrinsic acquired resistance mechanisms limit effective treatment options, making targeted therapy essential. Objectives: This narrative review summarizes the current understanding rare unusual NFGNB, their clinical significance, profiles, evidence-based strategies. Methods: A literature was conducted using PubMed, Scopus, Web Science to identify relevant studies on epidemiology, antimicrobial resistance, approaches NFGNB. Results: Rare NFGNB exhibits diverse mechanisms, including β-lactamase production, efflux pumps, porin modifications. Treatment selection depends species-specific susceptibility patterns, but some cornerstones can be individuated. Novel β-lactam/β-lactamase inhibitors combination being explored for multidrug-resistant isolates. However, data remain limited. Conclusions: The increasing incidence requires heightened awareness tailored approach. Given paucity guidelines, stewardship susceptibility-guided crucial in optimizing patient outcomes.

Language: Английский

Citations

0
Mortality Risk and Antibiotic Therapy for Patients with Infections Caused by Elizabethkingia Species—A Meta-Analysis DOI Creative Commons
Chienhsiu Huang,

Sufang Kuo,

Lichen Lin

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1529 - 1529

Published: Sept. 19, 2024

Background and Objectives: Patients with infections caused by Elizabethkingia species require prompt identification effective antibiotic treatment since these spp. are typically resistant to multiple antibiotics variable susceptibility patterns. Understanding the mortality risk of this disease is difficult because relatively low incidence lack published systematic evaluations factors for mortality. The aim present study was investigate in patients conducting a meta-analysis existing studies on infections. Materials Methods: Studies comparing who died from survived were considered inclusion. that reported one or more considered. Clinical predisposing variables, comorbidities, clinical outcomes among Results: included twenty 990 patients, 298 (30.1%) died. following identified: intensive care unit admission, need mechanical ventilation, immunosuppressive steroid therapy use, pneumonia, comorbid liver disease, use inappropriate antimicrobial therapy. Conclusions: appropriate critical management Antimicrobial testing would be reliable means guiding treatment. best drugs needed ensure optimal recommendations treating Elizabethkingia-related

Language: Английский

Citations

1
Bacteriological Profile of Patients With Stroke-Associated Pneumonia and Antimicrobial Susceptibility of Pathogens: A Cross-Sectional Study DOI Open Access

Sunita Mohapatra,

Basanti Kumari Pathi, Ipsa Mohapatra

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Stroke-associated pneumonia (SAP) is the aftermath of aspiration oropharyngeal secretions or stomach content. Mechanical ventilation and lowered immunity consciousness facilitate etiopathogenesis SAP. Antibiotic prophylaxis repeated culture sensitivity testing dampen drug susceptibility patterns pathogens. We accomplished this study to determine bacteriological profile patients with SAP antimicrobial pathogenic bacteria.

Language: Английский

Citations

1
Prevalence, and Microbiological and Clinical Characteristics of Elizabethkingia Isolates from a tertiary hospital in Jiangxi Province, China DOI Creative Commons

Xiuhua Kang,

Huaming Guo, Shanting Zhao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Background Elizabethkingia infections have gradually become life-threatening hospital-acquired worldwide with increasing morbidity, multidrug resistance, and poor prognosis. However, information on the epidemiological clinical characteristics of in mainland China is limited. The aim this study was to analyze molecular characteristics, drug susceptibility isolates from a hospital Jiangxi Province, China. Results mean age patients 61 years (excluding one 13-day-old infant) 74.8% were male. In total, 85.4% admitted Intensive Care Unit infected Elizabethkingia. COVID-19, respiratory disease, central venous catheterization rates significantly different (P <0.05) between surviving dying groups. Sequencing 103 identified 92 strains Elizabethkingia anopheles, eight meningoseptica, two bruuniana, strain ursingii. Vitek MS had correct identification rate 87% for E. anopheles. More than 90% isolates susceptible minocycline, but resistant other drugs, including ceftazidime, aztreonam, imipenem. Resistance genotype analysis showed that blaBlaB blaCME highly prevalent isolates. Molecular typing revealed 29 PFGE types clonal transmission wards. Conclusions Multidrug-resistant Elizabethkingiaare beingdetected at rates; larger database required bacterium. This could be beneficial subsequent determination optimal antimicrobial drugs treatment caused by strains. Our model most sufficient genetic diversity transmission; adequate attention should paid pathogen.

Language: Английский

Citations

0
Caseinolytic protease P (ClpP) is a c-di-GMP effector protein modulating motility, biofilm and virulence in Stenotrophomonas maltophilia DOI Creative Commons

Jie Deng,

Xiaoyu Sun,

Jiayi Wang

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1, P. 100023 - 100023

Published: Nov. 9, 2024

Language: Английский

Citations

0
Antimicrobial Susceptibility Patterns and Antimicrobial Therapy of Infections Caused by Elizabethkingia Species DOI Creative Commons
Chienhsiu Huang

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 1990 - 1990

Published: Dec. 2, 2024

Background and Objectives: Elizabethkingia species have become significant sources of infections acquired in hospital settings are commonly linked to high mortality rates. Antimicrobial resistance can be influenced by species, geographical location, antimicrobial susceptibility testing methods, the time bacterial isolation. There distinct patterns among investigation into potential antibiotic variations is beneficial. no guidance on treatment literature. Consequently, purpose this review was elaborate through a scoping existing studies antibiograms illness caused species. Materials Methods: A comprehensive literature search PubMed Web Science between 1 January 2000 30 April 2024 identified all studies, including those that examined therapy I considered for which only broth microdilution methods agar dilution were used. Results: The sensitivity levels meningoseptica piperacillin–tazobactam (5–100%), ciprofloxacin (0–43.4%), levofloxacin (30–81.8%), trimethoprim–sulfamethoxazole (0–100%), tigecycline (15–100%), minocycline (60–100%), rifampicin (94–100%) varied. anophelis (3.3–93.3%), (1–75%), (12–100%), (1.02–96.7%), (0–52.2%), (97.5–100%), (20.5–96%) miricola (41.6–94.0%), (14–75%), (77.0–100%), (18.0–100%), (50%), (100%), (66–85.7%) Conclusions: majority isolates susceptible rifampin. This issue requires professional knowledge integration recommendations.

Language: Английский

Citations

0