Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: March 29, 2023
Abstract
Background
The
past
few
years
have
witnessed
a
significant
increase
in
research
related
to
plant-derived
extracellular
vesicles
(PDEVs)
biological
and
medical
applications.
Using
biochemical
technologies,
multiple
independent
groups
demonstrated
the
important
roles
of
PDEVs
as
potential
mediators
involved
cell-cell
communication
exchange
bio-information
between
species.
Recently,
several
contents
been
well
identified
PDEVs,
including
nucleic
acids,
proteins,
lipids,
other
active
substances.
These
cargoes
carried
by
could
be
transferred
into
recipient
cells
remarkably
influence
their
behaviors
associated
with
human
diseases,
such
cancers
inflammatory
diseases.
Main
body
abstract
This
review
summarizes
latest
updates
regarding
focuses
on
its
role
nanomedicine
applications,
drug
delivery
strategies
develop
diagnostic
therapeutic
agents
for
clinical
management
especially
like
cancers.
Conclusion
Considering
unique
advantages,
high
stability,
intrinsic
bioactivity
easy
absorption,
further
elaboration
molecular
mechanisms
factors
driving
function
will
provide
new
horizons
treatment
disease.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(3)
Published: May 2, 2023
Protein
posttranslational
modifications
(PTMs)
refer
to
the
breaking
or
generation
of
covalent
bonds
on
backbones
amino
acid
side
chains
proteins
and
expand
diversity
proteins,
which
provides
basis
for
emergence
organismal
complexity.
To
date,
more
than
650
types
protein
modifications,
such
as
most
well-known
phosphorylation,
ubiquitination,
glycosylation,
methylation,
SUMOylation,
short-chain
long-chain
acylation
redox
irreversible
have
been
described,
inventory
is
still
increasing.
By
changing
conformation,
localization,
activity,
stability,
charges,
interactions
with
other
biomolecules,
PTMs
ultimately
alter
phenotypes
biological
processes
cells.
The
homeostasis
important
human
health.
Abnormal
may
cause
changes
in
properties
loss
functions,
are
closely
related
occurrence
development
various
diseases.
In
this
review,
we
systematically
introduce
characteristics,
regulatory
mechanisms,
functions
health
addition,
therapeutic
prospects
diseases
by
targeting
associated
enzymes
also
summarized.
This
work
will
deepen
understanding
promote
discovery
diagnostic
prognostic
markers
drug
targets
Scientific Reports,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: April 18, 2022
Abstract
NIMA
related
Kinases
(NEK7)
plays
an
important
role
in
spindle
assembly
and
mitotic
division
of
the
cell.
Over
expression
NEK7
leads
to
progression
different
cancers
associated
malignancies.
It
is
becoming
next
wave
targets
for
development
selective
potent
anti-cancerous
agents.
The
current
study
first
comprehensive
computational
approach
identify
inhibitors
protein.
For
this
purpose,
previously
identified
anti-inflammatory
compound
i.e.,
Phenylcarbamoylpiperidine-1,2,4-triazole
amide
derivatives
by
our
own
group
were
selected
their
anti-cancer
potential
via
detailed
Computational
studies.
Initially,
density
functional
theory
(DFT)
calculations
carried
out
using
Gaussian
09
software
which
provided
information
about
compounds'
stability
reactivity.
Furthermore,
Autodock
suite
Molecular
Operating
Environment
(MOE)
software’s
used
dock
ligand
database
into
active
pocket
Both
performances
compared
terms
sampling
power
scoring
power.
During
analysis,
results
found
be
more
reproducible,
implying
that
outperforms
MOE.
majority
compounds,
including
M7
,
M12
showed
excellent
binding
energies
formed
stable
protein–ligand
complexes
with
docking
scores
−
29.66
kJ/mol
31.38
kJ/mol,
respectively.
validated
molecular
dynamics
simulation
studies
where
conformational
transformation
best
complex
justified
on
basis
RMSD
RMSF
trajectory
analysis.
drug
likeness
properties
toxicity
profile
all
compounds
determined
ADMETlab
2.0.
anticancer
confirmed
cell
viability
(MTT)
assay.
This
suggested
can
further
investigated
at
level
evaluated
cancer
treatment
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: March 29, 2023
Abstract
Background
The
past
few
years
have
witnessed
a
significant
increase
in
research
related
to
plant-derived
extracellular
vesicles
(PDEVs)
biological
and
medical
applications.
Using
biochemical
technologies,
multiple
independent
groups
demonstrated
the
important
roles
of
PDEVs
as
potential
mediators
involved
cell-cell
communication
exchange
bio-information
between
species.
Recently,
several
contents
been
well
identified
PDEVs,
including
nucleic
acids,
proteins,
lipids,
other
active
substances.
These
cargoes
carried
by
could
be
transferred
into
recipient
cells
remarkably
influence
their
behaviors
associated
with
human
diseases,
such
cancers
inflammatory
diseases.
Main
body
abstract
This
review
summarizes
latest
updates
regarding
focuses
on
its
role
nanomedicine
applications,
drug
delivery
strategies
develop
diagnostic
therapeutic
agents
for
clinical
management
especially
like
cancers.
Conclusion
Considering
unique
advantages,
high
stability,
intrinsic
bioactivity
easy
absorption,
further
elaboration
molecular
mechanisms
factors
driving
function
will
provide
new
horizons
treatment
disease.
