Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: July 6, 2022
Abstract
The
tumor
microenvironment
(TME),
which
is
regulated
by
intrinsic
oncogenic
mechanisms
and
epigenetic
modifications,
has
become
a
research
hotspot
in
recent
years.
Characteristic
features
of
TME
include
hypoxia,
metabolic
dysregulation,
immunosuppression.
One
the
most
common
RNA
N6-methyladenosine
(m
6
A)
methylation,
widely
involved
regulation
physiological
pathological
processes,
including
development.
Compelling
evidence
indicates
that
m
A
methylation
regulates
transcription
protein
expression
through
shearing,
export,
translation,
processing,
thereby
participating
dynamic
evolution
TME.
Specifically,
methylation-mediated
adaptation
to
phenotypic
shift
immune
cells
synergistically
promote
formation
an
immunosuppressive
supports
proliferation
metastasis.
In
this
review,
we
have
focused
on
involvement
tumor-adaptive
described
detailed
linking
change
cell
biological
functions.
view
collective
data,
advocate
treating
as
complete
ecosystem
components
crosstalk
with
each
other
achieve
adaptive
changes.
Finally,
describe
potential
utility
methylation-targeted
therapies
immunotherapy
clinical
applications
challenges
faced,
aim
advancing
research.
Journal of Oncology,
Journal Year:
2021,
Volume and Issue:
2021, P. 1 - 10
Published: Nov. 23, 2021
N6-Methyladenosine
(m6A)
modification
is
a
dynamic
and
reversible
methylation
at
the
N6-position
of
adenosine.
As
one
most
prevalent
posttranscriptional
modifications
RNA,
m6A
participates
in
several
mRNA
processes,
including
nuclear
export,
splicing,
translation,
degradation.
Some
proteins,
such
as
METTL3,
METTL14,
WTAP,
ALKBH5,
FTO,
YTHDF1/2/3,
are
involved
methylation.
These
proteins
subdivided
into
writers
(METTL3,
WTAP),
erasers
(ALKBH5,
FTO),
readers
(YTHDF1/2/3)
according
to
their
functions
modification.
Several
studies
have
shown
that
abnormal
occurs
tumors,
colorectal
cancer,
liver
breast
nasopharyngeal
carcinoma,
gastric
cancer.
The
for
tumor
proliferation,
angiogenesis,
metastasis,
immunity,
other
processes.
Herein,
roles
cancer
discussed,
which
will
improve
understanding
tumorigenesis,
well
diagnosis,
treatment,
prognosis
tumors.
Biomolecules,
Journal Year:
2021,
Volume and Issue:
11(2), P. 304 - 304
Published: Feb. 18, 2021
MicroRNAs
(miRNAs)
are
well-known
regulators
of
biological
mechanisms
with
a
small
size
19-24
nucleotides
and
single-stranded
structure.
miRNA
dysregulation
occurs
in
cancer
progression.
miRNAs
can
function
as
tumor-suppressing
or
tumor-promoting
factors
via
regulating
molecular
pathways.
Breast
lung
cancers
two
malignant
thoracic
tumors
which
the
abnormal
expression
plays
significant
role
their
development.
Phosphatase
tensin
homolog
(PTEN)
is
tumor-suppressor
factor
that
capable
suppressing
growth,
viability,
metastasis
cells
downregulating
phosphatidylinositol
3-kinase
(PI3K)/protein
kinase
B
(Akt)
signaling.
PTEN
downregulation
breast
to
promote
PI3K/Akt
expression,
leading
uncontrolled
proliferation,
metastasis,
resistance
chemotherapy
radiotherapy.
upstream
mediators
dually
induce/inhibit
signaling
affecting
behavior
cells.
Furthermore,
long
non-coding
RNAs
circular
regulate
miRNA/PTEN
axis
It
seems
anti-tumor
compounds
such
baicalein,
propofol,
curcumin
induce
upregulation
by
These
topics
discussed
current
review
focus
on
Aging Cell,
Journal Year:
2021,
Volume and Issue:
20(2)
Published: Jan. 13, 2021
Abstract
Impaired
osteoblast
function
is
involved
in
osteoporosis,
and
microRNA
(miRNA)
dysregulation
may
cause
abnormal
osteogenic
activity.
However,
the
influence
of
miRNA
on
activity
underlying
mechanisms
remain
elusive.
In
this
study,
miR‐103‐3p
was
found
to
be
negatively
correlated
with
bone
formation
specimens
from
elderly
women
fractures
ovariectomized
(OVX)
mice.
Additionally,
directly
targeted
Mettl14
inhibit
activity,
METTL14‐dependent
N
6
‐methyladenosine
(m
A)
methylation
inhibited
processing
by
microprocessor
protein
DGCR8
promoted
Moreover,
vivo,
therapeutic
inhibition
counteracted
decreased
OVX
Further,
METTL14
but
positively
Collectively,
our
results
highlight
critical
roles
miR‐103‐3p/METTL14/m
A
signaling
axis
identifying
as
a
potential
target
for
ameliorating
osteoporosis.
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: July 6, 2022
Abstract
The
tumor
microenvironment
(TME),
which
is
regulated
by
intrinsic
oncogenic
mechanisms
and
epigenetic
modifications,
has
become
a
research
hotspot
in
recent
years.
Characteristic
features
of
TME
include
hypoxia,
metabolic
dysregulation,
immunosuppression.
One
the
most
common
RNA
N6-methyladenosine
(m
6
A)
methylation,
widely
involved
regulation
physiological
pathological
processes,
including
development.
Compelling
evidence
indicates
that
m
A
methylation
regulates
transcription
protein
expression
through
shearing,
export,
translation,
processing,
thereby
participating
dynamic
evolution
TME.
Specifically,
methylation-mediated
adaptation
to
phenotypic
shift
immune
cells
synergistically
promote
formation
an
immunosuppressive
supports
proliferation
metastasis.
In
this
review,
we
have
focused
on
involvement
tumor-adaptive
described
detailed
linking
change
cell
biological
functions.
view
collective
data,
advocate
treating
as
complete
ecosystem
components
crosstalk
with
each
other
achieve
adaptive
changes.
Finally,
describe
potential
utility
methylation-targeted
therapies
immunotherapy
clinical
applications
challenges
faced,
aim
advancing
research.
