Circular RNAs as biomarkers and therapeutic targets in cancer

Seminars in Cancer Biology, Journal Year: 2021, Volume and Issue: 83, P. 242 - 252

Published: Jan. 12, 2021

Language: Английский

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The role and application of small extracellular vesicles in gastric cancer

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: April 29, 2021

Abstract Gastric cancer (GC) is a common tumour that affects humans worldwide, highly malignant and has poor prognosis. Small extracellular vesicles (sEVs), especially exosomes, are nanoscale released by various cells deliver bioactive molecules to recipient cells, affecting their biological characteristics, changing the microenvironment producing long-distance effects. In recent years, many studies have clarified mechanisms which sEVs function with regard initiation, progression, angiogenesis, metastasis chemoresistance of GC. These can as mediators cell-cell communication in might affect efficacy immunotherapy. Due unique physiochemical show potential effective antitumour vaccines well drug carriers. this review, we summarize roles GC highlight clinical application prospects future.

Language: Английский

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CircRNAs and their regulatory roles in cancers

Molecular Medicine, Journal Year: 2021, Volume and Issue: 27(1)

Published: Aug. 26, 2021

Abstract Circular RNAs (circRNAs), a novel type of non-coding (ncRNAs), have covalently closed circular structure resulting from pre-mRNA back splicing via spliceosome and ribozymes. They can be classified differently in accordance with different criteria. As circRNAs are abundant, conserved, stable, they used as diagnostic markers various diseases targets to develop new therapies. There functions circRNAs, including sponge for miR/proteins, role scaffolds, templates translation, regulators mRNA translation stability. Without m7G cap poly-A tail, still degraded several ways, RNase L, Ago-dependent, Ago-independent degradation. Increasing evidence indicates that modified by N-6 methylation (m6A) many aspects such biogenesis, nuclear export, In addition, been proved play regulatory the progression cancers. Recently, methods detecting high sensitivity specificity also reported. This review presents detailed overview regarding biomarker, functions, degradation, dynamic modification well their roles It’s particularly summarized detail biogenesis regulation m6A mechanisms which affect tumor respectively. Moreover, existing circRNA detection characteristics mentioned.

Language: Английский

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The potential role of exosomal circRNAs in the tumor microenvironment: insights into cancer diagnosis and therapy

Theranostics, Journal Year: 2021, Volume and Issue: 12(1), P. 87 - 104

Published: Nov. 10, 2021

Exosomes are multifunctional regulators of intercellular communication by carrying various messages under both physiological and pathological status cancer patients. Accumulating studies have identified the presence circular RNAs (circRNAs) in exosomes with crucial regulatory roles diverse pathophysiological processes. Exosomal circRNAs derived from donor cells can modulate crosstalk recipient locally or remotely to enhance development propagation, play tumor microenvironment (TME), leading significant enhancement immunity, metabolism, angiogenesis, drug resistance, epithelial mesenchymal transition (EMT), invasion metastasis. In this review, we describe advances exosomal their modulating hallmarks, especially those TME. Moreover, clinical application potential diagnosis therapy highlighted, bridging gap between basic knowledge practice.

Language: Английский

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CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation

Oncogene, Journal Year: 2021, Volume and Issue: 40(15), P. 2756 - 2771

Published: March 13, 2021

Language: Английский

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