The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications DOI Creative Commons
Xiang‐Long Chen, Anran Zhang, Kangcheng Zhao

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102323 - 102323

Published: May 9, 2024

Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be maintained. In recent years, due to rise materials science, many bioactive functional have applied treatment combination drugs, satisfactory achieved. At present, research review antioxidant not complete. Based on existing studies, mechanism were summarized this paper, strategies based emerging reviewed.

Language: Английский

Mechanism of sorafenib resistance associated with ferroptosis in HCC DOI Creative Commons
Lingling Guo,

Cuntao Hu,

Mengwen Yao

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 7, 2023

Hepatocellular carcinoma (HCC) is the most familiar primary hepatic malignancy with a poor prognosis. The incidence of HCC and associated deaths have risen in recent decades. Sorafenib first drug to be approved by Food Drug Administration (FDA) for routine use first-line therapy patients advanced HCC. However, only about 30% will benefited from sorafenib therapy, resistance typically develops within 6 months. In years, mechanisms gained attention growing number researchers. A promising field current studies ferroptosis, which novel form cell death differing apoptosis, necroptosis, autophagy. This process dependent on accumulation intracellular iron reactive oxygen species (ROS). Furthermore, increase levels ROS can significantly observed cells resistant sorafenib. article reviews that are related evaluates relationship between ferroptosis resistance, explores new therapeutic approaches capable reversing through modulation ferroptosis.

Language: Английский

Citations

47
SIRT1 is a regulator of autophagy: Implications for the progression and treatment of myocardial ischemia-reperfusion DOI Creative Commons

Xiaoqing Ding,

Chenyu Zhu,

Wenhong Wang

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 199, P. 106957 - 106957

Published: Oct. 10, 2023

SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD

Language: Английский

Citations

47
Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines DOI Open Access
Jianli Chen, Xuan Wu, Dan Yin

et al.

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 249, P. 108485 - 108485

Published: July 3, 2023

Language: Английский

Citations

45
The interplay between autophagy and apoptosis: its implication in lung cancer and therapeutics DOI

Urmita Biswas,

Ranita Roy,

Swarnasree Ghosh

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 585, P. 216662 - 216662

Published: Feb. 2, 2024

Language: Английский

Citations

33
The role of oxidative stress in intervertebral disc degeneration: Mechanisms and therapeutic implications DOI Creative Commons
Xiang‐Long Chen, Anran Zhang, Kangcheng Zhao

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102323 - 102323

Published: May 9, 2024

Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be maintained. In recent years, due to rise materials science, many bioactive functional have applied treatment combination drugs, satisfactory achieved. At present, research review antioxidant not complete. Based on existing studies, mechanism were summarized this paper, strategies based emerging reviewed.

Language: Английский

Citations

30