Advances in the protein‑encoding functions of circular RNAs associated with cancer (Review) DOI Creative Commons
Wentao Yuan, Xiaolin Zhang, Hui Cong

et al.

Oncology Reports, Journal Year: 2023, Volume and Issue: 50(2)

Published: July 10, 2023

Circular RNAs (circRNAs) are a special class of non‑coding that widely expressed in tissues and cells. Owing to their lack 5'‑cap 3'‑polyadenylated [poly(A)] tail, they more structurally stable difficult degrade compared with linear RNA. Numerous studies published recently have suggested circRNAs can encode peptides or proteins through cap‑independent translation mechanisms participate the occurrence development cancer. In present review, mechanism underlying encoding by circRNAs, biological information tools available for predicting translation, identification verification translational abilities summarized analyzed. Finally, associated circRNA‑encoded polypeptides various types cancer summarized. this review its discussion on coding function, we hope provide novel perspectives possibilities treatment as knowledge area is added developed future.

Language: Английский

Exosomal circular RNAs: A chief culprit in cancer chemotherapy resistance DOI
Xu Guo,

Congying Gao,

Dong‐Hua Yang

et al.

Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 67, P. 100937 - 100937

Published: Feb. 2, 2023

Language: Английский

Citations

109
Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance DOI Creative Commons
Hong Lin, Di Wang, Pinghan Wang

et al.

Molecular Cancer, Journal Year: 2022, Volume and Issue: 21(1)

Published: July 18, 2022

Abstract The resistance of tumor cells to therapy severely impairs the efficacy treatment, leading recurrence and metastasis various cancers. Clarifying underlying mechanisms therapeutic may provide new strategies for overcoming cancer resistance. N6-methyladenosine (m6A) is most prevalent RNA modification in eukaryotes, involved regulation splicing, translation, transport, degradation, stability processing, thus affecting several physiological processes progression. As a novel type multifunctional non-coding RNAs (ncRNAs), circular (circRNAs) have been demonstrated play vital roles anticancer therapy. Currently, accumulating studies revealed mutual m6A circRNAs, their interaction can further influence sensitivity treatment. In this review, we mainly summarized recent advances circRNAs modulation resistance, as well interplay potential mechanisms, providing promising insights future directions reversal cancer.

Language: Английский

Citations

87
Coding, or non-coding, that is the question DOI Creative Commons
Laura Poliseno, Martina Lanza, Pier Paolo Pandolfi

et al.

Cell Research, Journal Year: 2024, Volume and Issue: 34(9), P. 609 - 629

Published: July 25, 2024

The advent of high-throughput sequencing uncovered that our genome is pervasively transcribed into RNAs are seemingly not translated proteins. It was also found non-coding RNA transcripts outnumber canonical protein-coding genes. This mindboggling discovery prompted a surge in research started unraveling the functional relevance these new genetic units, shaking classic definition "gene". While revolution still taking place, polysome/ribosome profiling and mass spectrometry analyses revealed peptides can be from non-canonical open reading frames. Therefore, it becoming evident coding vs dichotomy way blurrier than anticipated. In this review, we focus on several examples which binary classification genes outdated, since same bifunctional gene expresses both products. We discuss implications intricate usage terms molecular mechanisms expression biological outputs, often concordant, but surprisingly discordant. Finally, methodological caveats associated with study genes, highlight opportunities challenges therapeutic exploitation intricacy towards development anticancer therapies.

Language: Английский

Citations

23
CircRNA and lncRNA-encoded peptide in diseases, an update review DOI Creative Commons
Qian Yi,

Jianguo Feng,

Weiwu Lan

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 30, 2024

Language: Английский

Citations

18
Mechanisms of circular RNA degradation DOI Creative Commons

Longxin Ren,

Qingshan Jiang,

Liyi Mo

et al.

Communications Biology, Journal Year: 2022, Volume and Issue: 5(1)

Published: Dec. 9, 2022

Abstract Circular RNAs (CircRNAs) are a class of noncoding formed by backsplicing during cotranscriptional and posttranscriptional processes, they widely exist in various organisms. CircRNAs have multiple biological functions associated with the occurrence development many diseases. While biogenesis function circRNAs been extensively studied, there few studies on circRNA degradation only pathways for specific identified. Here we outline basic information about circRNAs, summarize research mechanisms discusses where this field might head, hoping to provide some inspiration guidance scholars who aim study circRNAs.

Language: Английский

Citations

40
The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications DOI Creative Commons

Ziying Liu,

Lei Gao, Long Cheng

et al.

Experimental & Molecular Medicine, Journal Year: 2023, Volume and Issue: 55(3), P. 487 - 501

Published: March 1, 2023

Abstract N6-methyladenosine (m6A) is one of the epigenetic modifications RNA. The addition this chemical mark to RNA molecules regulates gene expression by affecting fate molecules. This posttranscriptional modification reversible and regulated methyltransferase “writers” demethylase “erasers”. m6A-modified RNAs depends on function different “readers” that recognize bind them. Research m6A methylation has recently increased due its important role in regulating cancer progression. Noncoding (ncRNAs) are a class transcribed from genome but whose roles have been overlooked their lack well-defined potential for translation into proteins or peptides. However, misconception now completely overturned. ncRNAs regulate various diseases, especially tumors, it confirmed they play either tumor-promoting tumor-suppressing almost all types tumors. In review, we discuss ncRNA summarize mechanisms involved. Finally, progress research clinical treatment significance

Language: Английский

Citations

39
The emerging importance role of m6A modification in liver disease DOI Open Access

Sheng Wang,

Songsen Gao,

Wufei Ye

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114669 - 114669

Published: April 8, 2023

N6-methyladenosine (m6A) modification, as one of the most common types inner RNA modification in eukaryotes, plays a multifunctional role normal and abnormal biological processes. This type is modulated by m6A writer, eraser reader, which turn impact various processes metabolism, such processing, translation, nuclear export, localization decay. The current academic view holds that exerts crucial post-transcriptional modulation gene expression, involved multiple cellular functions, developmental disease However, potential molecular mechanism specific development liver have not been fully elucidated. In our review, we summarized latest research progress on disease, explored how these novel findings reshape knowledge metabolism. addition, also illustrated effect regeneration to prompt further exploration physiology pathology, providing new insights references for search therapeutic targets disease.

Language: Английский

Citations

30
Circular MTHFD2L RNA-encoded CM-248aa inhibits gastric cancer progression by targeting the SET-PP2A interaction DOI Creative Commons
Haohan Liu,

Deliang Fang,

Chaoyue Zhang

et al.

Molecular Therapy, Journal Year: 2023, Volume and Issue: 31(6), P. 1739 - 1755

Published: April 26, 2023

The available targeted therapies for gastric cancer (GC) are still limited, so it is important to discover novel molecules as potential treatment options. Proteins or peptides encoded by circular RNAs (circRNAs) increasingly reported play essential roles in malignancies. aim of the present study was identify an undiscovered protein circRNA and explore its key role molecular mechanism GC progression. CircMTHFD2L (hsa_circ_0069982) screened validated a downregulated with coding potential. circMTHFD2L, named CM-248aa, identified first time immunoprecipitation mass spectrometry. CM-248aa significantly GC, while low expression associated advanced tumor-node-metastasis (TNM) stage histopathological grade. Low could be independent risk factor poor prognosis. Functionally, instead circMTHFD2L suppressed proliferation metastasis vitro vivo. Mechanistically, competitively acidic domain SET nuclear oncogene (SET) acted endogenous inhibitor SET-protein phosphatase 2A interaction promote dephosphorylation AKT, extracellular signal-regulated kinase, P65. Our discovery revealed that prognostic biomarker therapeutic option GC.

Language: Английский

Citations

28
IGF2BPs as novel m6A readers: Diverse roles in regulating cancer cell biological functions, hypoxia adaptation, metabolism, and immunosuppressive tumor microenvironment DOI Creative Commons

Meiqi Duan,

Haiyang Liu, Shasha Xu

et al.

Genes & Diseases, Journal Year: 2023, Volume and Issue: 11(2), P. 890 - 920

Published: July 20, 2023

m6A methylation is the most frequent modification of mRNA in eukaryotes and plays a crucial role cancer progression by regulating biological functions. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP) are newly identified 'readers'. They belong to family RNA-binding proteins, which bind sites on different RNA sequences stabilize them promote progression. In this review, we summarize mechanisms upstream factors regulate IGF2BP cancer. The current literature analyzed here reveals that cell proliferation, survival, chemoresistance, inhibit apoptosis, also associated with glycolysis, angiogenesis, immune response tumor microenvironment. Therefore, discovery their as 'readers' characteristic re-expression IGF2BPs cancers, it important elucidate mechanism action immunosuppressive We describe detail regulatory interaction network downstream target RNAs discuss potential clinical applications diagnostic prognostic markers, well recent advances biology therapeutic value.

Language: Английский

Citations

25
The roles of m6A methylation in cervical cancer: functions, molecular mechanisms, and clinical applications DOI Creative Commons

Zhonghao Mao,

Bingyu Wang,

Teng Zhang

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(11)

Published: Nov. 11, 2023

Abstract Cervical cancer (CC) is a gynecological neoplasm with the highest incidence rate, primarily attributed to persistent infection of high-risk Human papillomavirus (HPV). Despite extensive research, pathogenesis CC remains unclear. N6-methyladenosine (m6A) methylation, most prevalent form epigenetic modification in RNA, intricately linked cell proliferation, metastasis, metabolism, and therapeutic resistance within tumor microenvironment (TME) CC. The involvement writer, reader, eraser m6A impacts advancement tumors through regulation RNA stability, nuclear export, translation efficiency, degradation. Here, we discuss biogenesis m6A, atypical expressions regulators, mechanisms molecular interactions, their functions Furthermore, elucidate non-coding RNA. In context precision medicine, advancements genomics, proteomics, high-throughput sequencing technologies, summarize application clinical diagnosis treatment Additionally, new perspectives on detection methods, immune regulation, nano-drug development are presented, which lay foundation for further research provide ideas

Language: Английский

Citations

24