Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 29, 2024
Brain
metastatic
cancer
poses
a
significant
clinical
challenge,
with
limited
treatment
options
and
poor
prognosis
for
patients.
In
recent
years,
immunotherapy
has
emerged
as
promising
strategy
addressing
brain
metastases,
offering
distinct
advantages
over
conventional
treatments.
This
review
explores
the
evolving
landscape
of
tumor
in
context
cancer,
focusing
on
intricate
interplay
between
microenvironment
(TME)
immunotherapeutic
approaches.
By
elucidating
complex
interactions
within
TME,
including
role
immune
cells,
cytokines,
extracellular
matrix
components,
this
highlights
potential
to
reshape
paradigm
metastases.
Leveraging
checkpoint
inhibitors,
cellular
immunotherapies,
personalized
strategies,
holds
promise
overcoming
challenges
posed
by
blood-brain
barrier
immunosuppressive
Through
comprehensive
analysis
current
research
findings
future
directions,
underscores
transformative
impact
management
new
insights
opportunities
precise
therapeutic
interventions.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(6)
Published: May 28, 2024
Currently,
tumor
treatment
modalities
such
as
immunotherapy
and
targeted
therapy
have
more
stringent
requirements
for
obtaining
growth
information
require
accurate
easy-to-operate
detection
methods.
Compared
with
traditional
tissue
biopsy,
liquid
biopsy
is
a
novel,
minimally
invasive,
real-time
tool
detecting
directly
or
indirectly
released
by
tumors
in
human
body
fluids,
which
suitable
the
of
new
modalities.
Liquid
has
not
been
widely
used
clinical
practice,
there
are
fewer
reviews
related
applications.
This
review
summarizes
applications
components
(e.g.,
circulating
cells,
DNA,
extracellular
vesicles,
etc.)
tumorigenesis
progression.
includes
development
process
techniques
biopsies,
early
screening
tumors,
detection,
guiding
therapeutic
strategies
(liquid
biopsy-based
personalized
medicine
prediction
response).
Finally,
current
challenges
future
directions
proposed.
In
sum,
this
will
inspire
researchers
to
use
technology
promote
realization
individualized
therapy,
improve
efficacy
provide
better
options
patients.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(7)
Published: Sept. 15, 2023
Abstract
Brain
diseases,
such
as
brain
tumors,
neurodegenerative
cerebrovascular
and
injuries,
are
caused
by
various
pathophysiological
changes,
which
pose
a
serious
health
threat.
disorders
often
difficult
to
treat
due
the
presence
of
blood–brain
barrier
(BBB).
Biomimetic
nanovesicles
(BNVs),
including
endogenous
extracellular
vesicles
(EVs)
derived
from
cells
artificial
nanovesicles,
possess
ability
penetrate
BBB
thus
can
be
utilized
for
drug
delivery
brain.
BNVs,
especially
EVs,
widely
distributed
in
body
fluids
usually
carry
disease‐related
signal
molecules
proteins,
RNA,
DNA,
may
also
analyzed
understand
etiology
pathogenesis
diseases.
This
review
covers
exhaustive
classification
characterization
BNVs
roles
involved
emphatically
focuses
on
nanotechnology‐integrated
disease
theranostics,
diagnosis
strategies
precise
therapeutic
regulations
(e.g.,
immunity
regulation,
disordered
protein
clearance,
anti‐neuroinflammation,
neuroregeneration,
angiogenesis,
gut–brain
axis
regulation).
The
remaining
challenges
future
perspectives
regarding
treatment
diseases
discussed
outlined.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: July 15, 2023
Abstract
The
diagnosis
of
brain
metastasis
(BrM)
has
historically
been
a
dooming
that
is
nothing
less
than
death
sentence,
with
few
treatment
options
for
palliation
or
prolonging
life.
Among
the
available,
radiotherapy
(RT)
and
surgical
resection
have
backbone
therapy.
Within
past
couple
years,
immunotherapy
(IT),
alone
in
combination
traditional
treatments,
emerged
as
reckoning
force
to
combat
spread
BrM
shrink
tumor
burden.
This
review
compiles
recent
reports
describing
potential
role
IT
various
cancers.
It
also
examines
impact
microenvironment
on
regulating
cancer
can
play
mitigating
spread.
Lastly,
this
focuses
future
new
clinical
trials
pushing
boundaries
BrM.
npj Precision Oncology,
Journal Year:
2025,
Volume and Issue:
9(1)
Published: Jan. 29, 2025
Brain
metastasis
leads
to
poor
outcomes
and
CNS
injury,
significantly
reducing
quality
of
life
survival
rates.
Advances
in
understanding
the
tumor
immune
microenvironment
have
revealed
promise
immunotherapies,
which,
alongside
surgery,
chemotherapy,
radiation,
offer
improved
for
some
patients.
However,
resistance
immunotherapy
remains
a
critical
challenge.
This
review
explores
landscape
brain
metastases,
current
therapies,
clinical
trials,
need
personalized,
biomarker-driven
approaches
optimize
outcomes.
Journal of Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
20(1)
Published: Aug. 23, 2022
Abstract
Small
extracellular
vesicles
(SEVs)
are
containing
DNA,
RNA,
and
proteins
involved
in
intercellular
communication
function,
playing
an
essential
role
the
growth
metastasis
of
tumors.
SEVs
present
various
body
fluids
can
be
isolated
extracted
from
blood,
urine,
cerebrospinal
fluid.
Under
both
physiological
pathological
conditions,
released
by
some
cells,
such
as
immune,
stem,
tumor
a
cytosolic
manner.
secreted
cells
called
tumor-derived
exosomes
(TEXs)
because
their
origin
corresponding
parent
cells.
Glioma
is
most
common
intracranial
tumor,
accounting
for
approximately
half
primary
tumors,
characterized
insidious
onset,
high
morbidity,
mortality
rate.
Complete
removal
tissues
surgery
difficult.
Chemotherapy
improve
survival
quality
patients
to
certain
extent;
however,
gliomas
prone
chemoresistance,
which
seriously
affects
prognosis
patients.
In
recent
years,
TEXs
have
played
vital
occurrence,
development,
associated
immune
response,
chemotherapy
resistance,
radiation
therapy
glioma.
This
article
reviews
glioma
progression,
drug
clinical
diagnosis.
