Immunotherapy revolutionizing brain metastatic cancer treatment: personalized strategies for transformative outcomes DOI Creative Commons
Ting Li,

Shichen Sun,

Yubing Li

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 29, 2024

Brain metastatic cancer poses a significant clinical challenge, with limited treatment options and poor prognosis for patients. In recent years, immunotherapy has emerged as promising strategy addressing brain metastases, offering distinct advantages over conventional treatments. This review explores the evolving landscape of tumor in context cancer, focusing on intricate interplay between microenvironment (TME) immunotherapeutic approaches. By elucidating complex interactions within TME, including role immune cells, cytokines, extracellular matrix components, this highlights potential to reshape paradigm metastases. Leveraging checkpoint inhibitors, cellular immunotherapies, personalized strategies, holds promise overcoming challenges posed by blood-brain barrier immunosuppressive Through comprehensive analysis current research findings future directions, underscores transformative impact management new insights opportunities precise therapeutic interventions.

Language: Английский

Advances in the Molecular Landscape of Lung Cancer Brain Metastasis DOI Open Access
Vanessa G. P. Souza, Rachel Paes de Araújo, Mariana R. Santesso

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 722 - 722

Published: Jan. 24, 2023

Lung cancer is one of the most frequent tumors that metastasize to brain. Brain metastasis (BM) common in advanced cases, being major cause patient morbidity and mortality. BMs are thought arise via seeding circulating tumor cells into brain microvasculature. In tissue, interaction with immune promotes a microenvironment favorable growth cells. Despite multimodal treatments advances systemic therapies, lung patients still have poor prognoses. Therefore, there an urgent need identify molecular drivers BM clinically applicable biomarkers order improve disease outcomes survival. The goal this review summarize current state knowledge on mechanisms metastatic spread how influenced by microenvironment, elucidate determinants regarding role genomic transcriptomic changes, including coding non-coding RNAs. We also present overview therapeutics novel treatment strategies for diagnosed from NSCLC.

Language: Английский

Citations

20
Exploring the Molecular Tumor Microenvironment and Translational Biomarkers in Brain Metastases of Non-Small-Cell Lung Cancer DOI Open Access

Jiexi Wen,

Jie Zeng Yu, Catherine Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2044 - 2044

Published: Feb. 7, 2024

Brain metastases represent a significant clinical challenge in the treatment of non-small-cell lung cancer (NSCLC), often leading to severe decline patient prognosis and survival. Recent advances imaging systemic treatments have increased detection rates brain metastases, yet outcomes remain dismal due complexity metastatic tumor microenvironment (TME) lack specific biomarkers for early targeted therapy. The intricate interplay between NSCLC cells surrounding TME is pivotal, influencing progression, immune evasion, response This underscores necessity deeper understanding molecular underpinnings microenvironment, identification actionable that can inform multimodal approaches. goal this review synthesize current insights into elucidate mechanisms metastases. Furthermore, we will explore promising horizon emerging biomarkers, both tissue- liquid-based, hold potential radically transform strategies enhancement outcomes.

Language: Английский

Citations

7
A brain metastasis liquid biopsy – Where are we now? DOI Creative Commons
Stephen Robinson, James de Boisanger, Frances M. G. Pearl

et al.

Neuro-Oncology Advances, Journal Year: 2024, Volume and Issue: 6(1)

Published: Jan. 1, 2024

Abstract Brain metastases remain a challenging and feared complication for patients with cancer research in this area has lagged behind into to other organs. Due their location the risks associated neurosurgical biopsies, biology underpinning brain response treatment evolution over time remains poorly understood. Liquid biopsies are proposed overcome many of limitations present tissue providing better representation tumor heterogeneity, facilitating repeated sampling, noninvasive assessment biology. Several different liquid biopsy approaches have been investigated including circulating cells, DNA, extracellular vesicles, tumor-educated platelets; however, these generally less effective assessing compared organs requiring improved techniques investigate approaches, studies combining and/or novel approaches. Through review, we highlight current state art define key unanswered questions related biopsies.

Language: Английский

Citations

5
Epigenetic regulation of pulmonary inflammation DOI Creative Commons
Shama Ahmad,

Xiao Lu Zhang,

Aftab Ahmad

et al.

Seminars in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 154, P. 346 - 354

Published: May 23, 2023

Language: Английский

Citations

11
Gastric cancer with brain metastasis: from molecular characteristics and treatment DOI Creative Commons
Yingze Zhu, Miao Zhou,

C F Li

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: March 21, 2024

Gastric cancer is one of the cancers with increasing incidence and ranks fourth globally among most frequent causes cancer-related mortality. Early gastric often asymptomatic or presents atypical symptoms, majority patients present advanced disease upon diagnosis. Brain metastases are in approximately 1% at time diagnosis, which significantly contributed to overall mortality worldwide. Conventional therapies for brain remain limited median survival only 8 months cases. Recent studies have improved our understanding molecular mechanisms underlying metastases, immunotherapy has become an important treatment option combination radiotherapy, chemotherapy, targeted therapy surgery. This review aims provide insight into cellular processes involved discuss diagnostic approaches, evaluate integration immune checkpoint inhibitors prognosis, explore predictive value biomarkers immunotherapy.

Language: Английский

Citations

4
Brain metastasis: An insight into novel molecular targets for theranostic approaches DOI Creative Commons
Liliana Santos, João Nuno Moreira, Antero Abrunhosa

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 198, P. 104377 - 104377

Published: May 6, 2024

Brain metastases (BrM) are common malignant lesions in the central nervous system, and pose a significant threat advanced-stage malignancies due to delayed diagnosis limited therapeutic options. Their distinct genomic profiles underscore need for molecular profiling tailor effective treatments. Recent advances cancer biology have uncovered drivers underlying tumor initiation, progression, metastasis. This, coupled with imaging technology radiotracer synthesis, has paved way development of innovative radiopharmaceuticals enhanced specificity affinity BrM specific targets. Despite challenges posed by blood-brain barrier drug delivery, several radiolabeled compounds shown promise detecting targeting BrM. This manuscript provides an overview recent biomarkers used nuclear targeted radionuclide therapy both clinical preclinical settings. Additionally, it explores potential theranostic applications addressing unique

Language: Английский

Citations

4
Emerging role of chemokines in small cell lung cancer: Road signs for metastasis, heterogeneity, and immune response DOI
Parvez Κhan,

Mahek Fatima,

Md Arafat Khan

et al.

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 87, P. 117 - 126

Published: Nov. 9, 2022

Language: Английский

Citations

19
Longitudinal Monitoring of Circulating Tumor DNA to Assess the Efficacy of Immune Checkpoint Inhibitors in Patients With Advanced Genitourinary Malignancies DOI Creative Commons
Albert Jang, Sree M Lanka, Ellen B. Jaeger

et al.

JCO Precision Oncology, Journal Year: 2023, Volume and Issue: 7

Published: July 19, 2023

Circulating tumor DNA (ctDNA) detection in blood has emerged as a prognostic and predictive biomarker demonstrating improved assessment of treatment response patients receiving immune checkpoint inhibitors (ICIs). Here, we performed pilot study to support the role ctDNA for longitudinal monitoring with advanced genitourinary (GU) malignancies ICIs.Patients histologically confirmed GU were prospectively enrolled. All eligible received ICI at least 12 weeks, followed by serial collection samples every 6-8 weeks conventional scans approximately until disease progression. analysis was using Signatera, tumor-informed multiplex-polymerase chain reaction next-generation sequencing assay. Overall, objective rate (ORR) reported its association status evaluated. Concordance between dynamics imaging also assessed.ctDNA on 98 banked plasma from 20 (15 renal, four urothelial, one prostate). The median follow-up time initiation progressive (PD) or data cutoff 67.7 (range, 19.6-169.6). ORR 70% (14/20). Eight ultimately developed PD. overall concordance radiographic observed 83% (15/18) patients. Among three discordant results, two CNS metastases progressed extracranial systemic while remained undetectable.In this study, tumors feasible. Larger prospective studies are warranted validate utility an tool malignancies.

Language: Английский

Citations

10
Enhancing Brain Tumor Diagnosis: Transitioning From Convolutional Neural Network to Involutional Neural Network DOI Creative Commons
Abdullah A. Asiri, Ahmad Shaf, Tariq Ali

et al.

IEEE Access, Journal Year: 2023, Volume and Issue: 11, P. 123080 - 123095

Published: Jan. 1, 2023

Accurate classification of brain tumors is essential for effective medical diagnosis and treatment planning. Traditional approaches rely on convolutional neural networks (CNNs) tumor detection, but they often suffer from high computational demands due to the large number parameters. In this paper, we propose a novel approach using involutional (InvNets), which are designed mitigate parameter-intensive nature CNNs. Unlike spatial-agnostic channel-specific convolution kernel, involution kernel location-specific channel-agnostic. This operation allows network adapt various visual patterns with respect different spatial locations, enhancing its ability capture intricate features within images. Our study focuses four-class problem, aiming differentiate between types based imaging data. comparative analysis, demonstrate that conventional CNNs require over 4 million parameters, whereas our proposed InvNets less than 0.2 making them more efficient resource-friendly. The evaluation both carried out standard performance matrices: accuracy, precision, recall, F1 score, AUC-ROC values. findings reveal consistently outperform traditional InvNet architecture achieves an impressive 92% accuracy rate, showcasing potential accurate classification. improved combined reduced parameter count, highlights effectiveness image analysis tasks, especially in scenarios limited resources.

Language: Английский

Citations

10
CAF‐derived exosomal LINC01711 promotes breast cancer progression by activating the miR‐4510/NELFE axis and enhancing glycolysis DOI
Shuang Tao,

Yali Gao,

Xiang Wang

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(7)

Published: April 2, 2025

Breast cancer (BRCA) is among the most prevalent malignancies in women, characterized by a complex tumor microenvironment significantly influenced cancer-associated fibroblasts (CAFs). CAFs contribute to progression secreting exosomes that can modulate cell behavior. This study highlights how CAF-derived transmit long non-coding RNA (lncRNA) LINC01711, which activates TXN through miR-4510/NELFE axis, thereby enhancing glycolysis BRCA cells. Utilizing single-cell sequencing data from GEO database, employed dimensionality reduction, clustering, and annotation techniques uncover central role of NELFE BRCA. Experimental findings revealed LINC01711 highly expressed exosomes, upregulate via promoting glycolytic pathway subsequently increasing proliferation, migration, invasion potential These results shed light on novel molecular mechanism underlying suggest targets for therapeutic intervention.

Language: Английский

Citations

0