Experimental Neurology, Journal Year: 2024, Volume and Issue: 379, P. 114842 - 114842
Published: May 31, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14928 - 14928
Published: Oct. 5, 2023
Adenosine, an immunosuppressive metabolite, is produced by adenosine triphosphate (ATP) released from dying or stressed cells and found at high levels in the tumor microenvironment of most solid tumors. It mediates pro-tumor activities inducing cell proliferation, migration invasion, tissue angiogenesis, chemoresistance. In addition, plays important role regulating anti-tumor immune responses facilitating escape. Adenosine receptors are broadly expressed tumor-infiltrated cells, including suppressive tumor-associated macrophages CD4+ regulatory T as well effector CD8+ cytotoxic lymphocytes. Therefore, indispensable down-regulating contributes to progression. This review describes current progress on adenosine/adenosine receptor pathway tumor-infiltrating that contribute evasion aims provide insights into adenosine-targeted immunotherapy.
Language: Английский
Citations
31
Cell Death Discovery, Journal Year: 2023, Volume and Issue: 9(1)
Published: June 23, 2023
Abstract Pathogens or danger signals trigger the immune response. Moderate response activation removes pathogens and avoids excessive inflammation tissue damage. Histone demethylases (KDMs) regulate gene expression play essential roles in numerous physiological processes by removing methyl groups from lysine residues on target proteins. Abnormal of KDMs is closely associated with pathogenesis various inflammatory diseases such as liver fibrosis, lung injury, autoimmune diseases. Despite becoming exciting targets for diagnosing treating these diseases, role enzymes regulation still unclear. Here, we review underlying mechanisms through which immune-related pathways responses. In addition, also discuss future applications inhibitors
Language: Английский
Citations
29
Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 451 - 451
Published: March 5, 2024
Natural killer (NK) cells have gained attention as a promising adoptive cell therapy platform for their potential to improve cancer treatments. NK offer distinct advantages over T-cells, including major histocompatibility complex class I (MHC-I)-independent tumor recognition and low risk of toxicity, even in an allogeneic setting. Despite this tremendous potential, challenges persist, such limited vivo persistence, reduced infiltration, absolute numbers. This review outlines several strategies aiming overcome these challenges. The developed include optimizing expansion methods improving antitumor responses by cytokine stimulation genetic manipulations. Using K562 expressing membrane IL-15 or IL-21 with without additional activating ligands like 4-1BBL allows “massive” makes multiple dosing “off-the-shelf” efforts feasible. Further improvements function can be reached inducing memory-like cells, developing chimeric antigen receptor (CAR)-NK isolating NK-cell-based tumor-infiltrating lymphocytes (TILs). Memory-like demonstrate higher persistence cytotoxicity, early clinical trials demonstrating safety efficacy. Recent using CAR-NK also demonstrated lack any release syndrome, and, yet, activity. data support that the presence TIL-NK is associated improved overall patient survival different types solid tumors head neck, colorectal, breast, gastric carcinomas, among most significant. In conclusion, presents insights into diverse available expansion, roles played various cytokines, feeder culture material influencing activation phenotype, telomere length, cytotoxic expanded cells. Notably, genetically modified significant efficacy promoting expansion. Furthermore, culturing IL-2 has been shown rates, while IL-12 linked enhanced function. Overall, provides overview methodologies, highlighting current landscape key advancements enhance therapy.
Language: Английский
Citations
15
Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)
Published: Sept. 3, 2024
Abstract Tumor cells possess complex immune evasion mechanisms to evade system attacks, primarily through metabolic reprogramming, which significantly alters the tumor microenvironment (TME) modulate cell functions. When a is sufficiently immunogenic, it can activate cytotoxic T-cells target and destroy it. However, tumors adapt by manipulating their pathways, particularly glucose, amino acid, lipid metabolism, create an immunosuppressive TME that promotes escape. These alterations impact function differentiation of non-tumor within TME, such as inhibiting effector T-cell activity while expanding regulatory myeloid-derived suppressor cells. Additionally, these changes lead imbalance in cytokine chemokine secretion, further enhancing landscape. Emerging research increasingly focusing on roles evaluating how reprogrammed metabolism influence functional ultimately aid evasion. Despite our incomplete understanding intricate interactions between cells, connection elements presents significant challenges for cancer immunotherapy. This review highlights altered providing new insights could facilitate development novel immunotherapies.
Language: Английский
Citations
15
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: March 3, 2024
Abstract Natural killer (NK) cells are unique from other immune in that they can rapidly kill multiple neighboring without the need for antigenic pre-sensitization once display surface markers associated with oncogenic transformation. Given dynamic role of NK tumor surveillance, cell-based immunotherapy is becoming a "new force" immunotherapy. However, challenges remain use cell treatment solid tumors. Many metabolic features microenvironment (TME) tumors, including oxygen and nutrient (e.g., glucose, amino acids) deprivation, accumulation specific metabolites lactate, adenosine), limited availability signaling molecules allow reorganization, multifactorial shaping immune-suppressing TME impairs tumor-infiltrating function. This becomes key barrier limiting success Restoration endogenous or overt transfer functionally improved holds great promise cancer therapy. In this paper, we summarize biology cells, discuss effects on metabolism effector functions, review emerging strategies targeting metabolism-improved to circumvent these barriers achieve superior efficacy
Language: Английский
Citations
14
Med, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
11
Deleted Journal, Journal Year: 2024, Volume and Issue: 2(1)
Published: Jan. 1, 2024
Abstract Immunotherapy, specifically immune checkpoint inhibitors, is revolutionizing cancer treatment, achieving durable control of previously incurable or advanced tumors. However, only a certain group patients exhibit effective responses to immunotherapy. Anti‐angiogenic therapy aims block blood vessel growth in tumors by depriving them essential nutrients and effectively impeding their growth. Emerging evidence shows that tumor vessels structural functional abnormalities, resulting an immunosuppressive microenvironment poor response Both preclinical clinical studies have used anti‐angiogenic agents enhance the effectiveness immunotherapy against cancer. In this review, we concentrate on synergistic effect therapies management, dissect direct effects underlying mechanisms recruiting activating cells, discuss potential improve Lastly, outline challenges opportunities for strategy Considering increasing approval combination treating cancers, comprehensive review would be timely important.
Language: Английский
Citations
10
Nano Letters, Journal Year: 2024, Volume and Issue: 24(11), P. 3421 - 3431
Published: Feb. 20, 2024
Natural killer (NK) cell-based adoptive immunotherapy has demonstrated encouraging therapeutic effects in clinical trials for hematological cancers. However, the effectiveness of treatment solid tumors remains a challenge due to insufficient recruitment and infiltration NK cells into tumor tissues. Herein, programmed nanoremodeler (DAS@P/H/pp) is designed remodel dense physical stromal barriers dysregulation chemokine environment enhance tumors. The DAS@P/H/pp triggered by acidic environment, resulting charge reversal subsequent hyaluronidase (HAase) release. HAase effectively degrades extracellular matrix, promoting delivery immunoregulatory molecules chemotherapy drugs deep In mouse models pancreatic cancer, this nanomediated strategy remodeling microenvironment significantly boosts NK92 their cell-killing capabilities under supervision multiplexed near-infrared-II fluorescence.
Language: Английский
Citations
10
Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 24, 2024
Language: Английский
Citations
9
Cancers, Journal Year: 2023, Volume and Issue: 15(21), P. 5135 - 5135
Published: Oct. 25, 2023
Background: Cancer cases are continuously increasing, while the prevalence rates of physical inactivity also increasing. Physical is a causative factor in non-communicable diseases, including cancer. However, potential beneficial effects exercise on cancer treatment have not received much attention so far. The aim this study was to highlight relationship between and molecular basis. Methods: Comprehensive in-depth research conducted most accurate scientific databases by using relevant effective keywords. Results: mechanisms which may reduce risk and/or progression include metabolic profile hormones, systemic inflammation reduction, insulin sensitivity increase, antioxidant capacity augmentation, boost immune system, direct effect tumor. There currently substantial evidence that predict stronger association with could supplementarily be embedded clinical practice improve disease prognosis. Conclusion: field requires interconnecting overall knowledge physiology biology oncology provide basis for personalized targeting strategies can merged training as component holistic co-treatment approach optimize healthcare.
Language: Английский
Citations
20