Neutrophils: a Central Point of Interaction Between Immune Cells and Nonimmune Cells in Rheumatoid Arthritis DOI
Zhaoran Wang, Yi Jiao,

Wenya Diao

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: March 28, 2025

Language: Английский

CCL20 in the tumor microenvironment: implications for cancer progression and therapeutic approaches DOI Creative Commons
Louis Boafo Kwantwi,

James Danquah Boafo,

Bevelyn Emefa Egleh

et al.

Clinical & Translational Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract Increasing knowledge of the immunosuppressive tumor microenvironment in cancer-related processes has led to developing novel immune-based therapies that have changed cancer treatment paradigm. In microenvironment, plethora soluble factors secreted by cells interacts with immune and non-immune components deliver signals necessary for progression. Accordingly, targeting tumor-derived inducing this become an appealing therapeutic potential advancing treatment. CCL20, a chemokine best known induce leucocyte migration response pathological inflammatory conditions, been implicated proliferation, angiogenesis, metastasis, immunosuppression, resistance. Notably, CCL20 its receptor CCR6 are important interactions. This review discusses interaction between CCL20–CCR6 axis how these interactions promote Also, outline studies utilizing combination other standard treatments shed.

Language: Английский

Citations

0
YTHDF1-targeting nanoassembly reverses tumoral immune evasion through epigenetics and cell cycle modulation DOI
Hongting Liu,

X Zhang,

Feng Ding

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
GINS1 is a prognostic biomarker and correlated with methylation and immune escape in liver hepatocellular carcinoma DOI Creative Commons

Mingchao Liang,

Tianqi Lai, Zhen Li

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 7, 2025

GINS1 is correlated with a poor prognosis in numerous cancers including liver hepatocellular carcinoma (LIHC). Here, efforts have been made to explore the function and underlying mechanism LIHC through bioinformatics analysis. The mRNA protein expression data of were downloaded from Cancer Genome Atlas (TCGA) database, Clinical Proteomic Tumor Analysis Consortium (CPTAC), University Alabama at Birmingham CANcer Data Portal (UALCAN), Human Protein (HPA) database. Moreover, was further substantiated by immunohistochemistry staining 116 clinical samples. Subsequently, diagnostic prognostic role patients determined using receiver operating characteristic (ROC) analysis Kaplan-Meier plotter (KM-plotter) GeneMANIA STRING databases respectively used construct gene protein-protein interaction (PPI) networks GINS1. Enrichment analyses conducted investigate functions To assess genetic alterations, methylation, value, cBioPortal, MethSurv utilized. Additionally, Immune Estimation Resource (TIMER), Tumor-Immune System Interaction Database (TISIDB), Gene Expression Profiling Interactive (GEPIA) correlation tumor immune. Differential validated upregulation LIHC. Furthermore, values ROC curve, plotters, forest plots. Further enrichment, immune microenvironment showed an intimate connection In conclusion, which methylation escape may predict

Language: Английский

Citations

0
Intestinal Microbiota and Vaccinations: A Systematic Review of the Literature DOI Creative Commons

Francesco Loddo,

Pasqualina Laganà, Caterina Elisabetta Rizzo

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(3), P. 306 - 306

Published: March 12, 2025

Background: Vaccination constitutes a low-cost, safe, and efficient public health measure that can help prevent the spread of infectious diseases benefit community. The fact vaccination effectiveness varies among populations, causes this are still unclear, indicates several factors involved should be thoroughly examined. “intestinal microbiota” is most crucial these elements. Numerous clinical studies demonstrate intestinal microbiota’s significance in determining alleged “immunogenicity” efficacy vaccines. This systematic review aimed to all relevant scientific literature highlight role microbiota COVID-19, Salmonella typhi, Vibrio cholerae, rotavirus vaccinations. Materials Methods: MESH terms “vaccines” “microbiota” were used search major databases PubMed, SciVerse Scopus, Web Knowledge, Cochrane Central Register Controlled Clinical Trials. Results: Between February 2024 October 2024, analysis was conducted using electronic databases, yielding total 235 references. Finally, 24 RCTs chosen after meeting inclusion criteria: eight two three eleven rotavirus. Only six demonstrated good study quality with Jadad score or four. Conclusions: According review’s results, surely plays vaccinations’ enhanced immunogenicity, especially younger people. As it unclear what mechanisms underlie effect, more research needed better understand microbiota.

Language: Английский

Citations

0
Neutrophils: a Central Point of Interaction Between Immune Cells and Nonimmune Cells in Rheumatoid Arthritis DOI
Zhaoran Wang, Yi Jiao,

Wenya Diao

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: March 28, 2025

Language: Английский

Citations

0