Advances in healthcare information systems and administration book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 261 - 282
Published: Feb. 9, 2024
Recent
years
have
witnessed
a
significant
convergence
of
artificial
intelligence
(AI)
within
the
healthcare
sector.
This
chapter
explores
transformative
potential
and
challenges
posed
by
these
intelligent
technologies
in
healthcare.
It
various
domains
such
as
predictive
analytics,
telemedicine,
personalized
medicine,
enhancement
operational
efficiencies.
The
findings
underscore
AI
smart
revolutionizing
delivery.
carries
extensive
implications
for
Healthcare
practitioners
administrators
can
leverage
insights
to
strategically
incorporate
solutions,
aiming
improve
patient
outcomes
enhance
organizational
efficiency.
Additionally,
provide
valuable
guidance
policymakers
stakeholders,
informing
creation
guidelines
standards
that
foster
innovation,
ensure
safety,
protect
data
security.
Therefore,
this
is
an
essential
guide
effectively
embracing
role
advancing
practices.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: June 12, 2024
Abstract
The
growing
interest
in
using
plant
extracts
for
the
biogenic
synthesis
of
zinc
oxide
nanoparticles
(ZnO
NPs)
stems
from
their
facile,
eco-friendly,
and
biologically
safe
approach
instead
chemical
routes.
For
first
time,
ZnO
NPs
were
successfully
biosynthesized
Rhus
coriaria
fruit
aqueous
extract
as
a
reducing
capping
agent.
Characterization
revealed
that
possessed
maximum
absorbance
approximately
359
nm
closely
resembled
hexagonal
wurtzite
crystalline
structure,
with
an
average
size
16.69
nm.
transmission
electron
microscope
(TEM)
showed
presence
spherical
morphologies,
grain
20.51
±
3.90
Moreover,
elemental
composition
synthesized
was
assessed
via
energy-dispersive
X-ray
spectrometry
(EDX),
phytocompounds
on
surface
subsequently
verified
through
FT-IR
analysis.
ζ-potential
recorded
at
−
19.9
0.1663
mV.
Regarding
anti-cancer
properties,
found
to
possess
potent
anti-tumor
effects
MCF-7
MDA-MB-231
breast
cancer
cells.
Their
efficacy
dose-dependent,
IC
50
values
ranging
35.04–44.86
μg/mL
55.54–63.71
µg/mL
Mechanistic
studies
cells
apoptosis
induction,
validated
by
DAPI
staining,
confocal
microscopy,
Annexin
V/PI
showing
12.59%
81.57%
½
values,
respectively.
Additionally,
observed
provoke
S-phase
arrest
inhibit
colony-forming
metastatic
potential
modulating
metastasis-related
genes.
This
study
unravels
new
insights
into
how
cell
death
metastasis,
revealing
prospects
nanotechnology.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 2529 - 2552
Published: March 1, 2024
Abstract:
The
blood-brain
barrier
(BBB)
and
blood-tumor
(BTB)
pose
substantial
challenges
to
efficacious
drug
delivery
for
glioblastoma
multiforme
(GBM),
a
primary
brain
tumor
with
poor
prognosis.
Nanoparticle-based
combinational
strategies
have
emerged
as
promising
modalities
overcome
these
barriers
enhance
penetration
into
the
parenchyma.
This
review
discusses
various
nanoparticle-based
combinatorial
approaches
that
combine
nanoparticles
cell-based
delivery,
viral
focused
ultrasound,
magnetic
field,
intranasal
permeability
across
BBB
BTB.
Cell-based
involves
using
engineered
cells
carriers
nanoparticles,
taking
advantage
of
their
intrinsic
migratory
homing
capabilities
facilitate
transport
therapeutic
payloads
Viral
uses
vectors
deliver
genes
or
specific
within
GBM
microenvironment.
Focused
coupled
microbubbles
can
temporarily
disrupt
increase
permeability.
Magnetic
field-guided
exploits
targeted
under
an
external
field.
Intranasal
offers
minimally
invasive
avenue
bypass
agents
directly
via
olfactory
trigeminal
pathways.
By
combining
strategies,
synergistic
effects
efficiency,
improve
efficacy,
reduce
off-target
effects.
Future
research
should
focus
on
optimizing
nanoparticle
design,
exploring
new
combination
advancing
preclinical
clinical
investigations
promote
translation
therapies
GBM.
Keywords:
glioblastoma,
barrier,
nanoparticle,
strategy,
ultrasound-wave,
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(1), P. 70 - 70
Published: Jan. 7, 2025
Malignant
growth
is
expected
to
surpass
other
significant
causes
of
death
as
one
the
top
reasons
for
dismalness
and
mortality
worldwide.
According
a
World
Health
Organization
(WHO)
study,
this
illness
approximately
between
9
10
million
instances
deaths
annually.
Chemotherapy,
radiation,
surgery
are
three
main
methods
treating
cancer.
These
seek
completely
eradicate
all
cancer
cells
while
having
fewest
possible
unintended
impacts
on
healthy
cell
types.
Owing
lack
target
selectivity,
majority
medications
have
substantial
side
effects.
On
hand,
nanomaterials
transformed
identification,
diagnosis,
management
Nanostructures
with
biomimetic
properties
been
grown
late,
fully
intent
observing
sickness.
nanostructures
be
consumed
by
in
areas
profound
disease.
Furthermore,
because
their
extraordinary
physicochemical
properties,
which
incorporate
nanoscale
aspects,
more
prominent
surface
region,
explicit
geometrical
features,
ability
embody
different
substances
within
or
outside
surfaces,
remarkable
nano-vehicles
conveying
restorative
specialists
designated
regions.
This
review
discusses
recent
developments
nanostructured
materials
such
graphene,
dendrimers,
cell-penetrating
peptide
nanoparticles,
nanoliposomes,
lipid
magnetic
nano-omics
diagnosis
