Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 339 - 352
Published: Dec. 6, 2024
Language: Английский
Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2750 - 2750
Published: Nov. 30, 2024
The field of personalized medicine is undergoing a transformative shift through the integration multi-omics data, which mainly encompasses genomics, transcriptomics, proteomics, and metabolomics. This synergy allows for comprehensive understanding individual health by analyzing genetic, molecular, biochemical profiles. generation data enable more precise tailored therapeutic strategies, improving efficacy treatments reducing adverse effects. However, several challenges hinder full realization medicine. Key hurdles include complexity across different omics layers, need advanced computational tools, high cost generation. Additionally, issues related to privacy, standardization, robust validation in diverse populations remain significant obstacles. Looking ahead, future promises advancements technology methodologies that will address these challenges. Emerging innovations analytics, machine learning, high-throughput sequencing are expected enhance making accessible effective. Collaborative efforts among researchers, clinicians, industry stakeholders crucial overcoming fully harnessing potential individualized healthcare.
Language: Английский
Citations
18
Current Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 21(1), P. 20 - 32
Published: Dec. 1, 2024
Language: Английский
Citations
12
Acta Neuropathologica Communications, Journal Year: 2025, Volume and Issue: 13(1)
Published: Jan. 11, 2025
Abstract Glioblastoma (GBM) is a highly aggressive adult brain cancer, characterised by poor prognosis and dismal five-year survival rate. Despite significant knowledge gains in tumour biology, meaningful advances patient remain elusive. The field of neuro-oncology faces many disease obstacles, one being the paucity faithful models to advance preclinical research guide personalised medicine approaches. Recent technological developments have permitted maintenance, expansion cryopreservation GBM explant organoid (GBO) tissue. GBOs represent translational leap forward are currently state-of-the-art 3D vitro culture system, retaining cancer heterogeneity, transiently maintaining immune infiltrate microenvironment (TME). Here, we provide review existing technologies, vivo xenograft approaches, evaluate in-detail key advantages limitations this rapidly emerging technology, consider solutions overcome these difficulties. hold promise, with potential emerge as tool synergise enhance next-generation omics efforts approaches for patients into future.
Language: Английский
Citations
1
Translational Oncology, Journal Year: 2025, Volume and Issue: 53, P. 102307 - 102307
Published: Feb. 3, 2025
Language: Английский
Citations
1
Cellular and Molecular Life Sciences, Journal Year: 2025, Volume and Issue: 82(1)
Published: Feb. 19, 2025
Language: Английский
Citations
1
Trends in Cell Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Trends in Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 457 - 457
Published: March 19, 2025
Colorectal epithelium was the first long-term 3D organoid culture established in vitro. Identification of key components essential for survival stem cell niche allowed an indefinite propagation these cultures and modulation their differentiation into various lineages mature intestinal epithelial cells. While methods were eventually adapted to establish organoids from different organs, colorectal remain a pioneering model development new applications health disease. Several basic applicative aspects culture, modeling, monitoring testing are analyzed this review. We also tackle ethical problems biobanking distribution precious research tools, frequently confined laboratory origin or condemned destruction at end project.
Language: Английский
Citations
0
Published: May 1, 2025
Language: Английский
Citations
0
MedComm, Journal Year: 2024, Volume and Issue: 5(9)
Published: Sept. 1, 2024
Abstract Genomics allows the tracing of origin and evolution cancer at molecular scale underpin modern diagnosis treatment systems. Yet, biomarker‐guided clinical decision‐making encounters major challenges in realm individualized medicine, consisting invasiveness procedures sampling errors due to high tumor heterogeneity. By contrast, medical imaging enables noninvasive global characterization tumors a low cost. In recent years, radiomics has overcomes limitations human visual evaluation by high‐throughput quantitative analysis, enabling comprehensive utilization vast amount information underlying radiological images. The cross‐scale integration genomics (hereafter radiogenomics) enormous potential enhance decoding act as catalyst for digital precision medicine. Herein, we provide overview current framework applications radiogenomics patient care. We also highlight research advances illustrate how can address common problems solid such breast cancer, lung glioma. Finally, analyze existing literature outline propose solutions, while identifying future pathways. believe that perspectives shared this survey will valuable guide researchers aiming advance oncology.
Language: Английский
Citations
2