Metabolic regulation of the immune system in health and diseases: mechanisms and interventions

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 9, 2024

Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes functions of immune cells. The regulation system is important in pathogenesis progression numerous diseases, such as cancers, autoimmune diseases diseases. concept immunometabolism was introduced over a decade ago to elucidate intricate interplay between metabolism immunity. definition has expanded from chronic low-grade inflammation reprogramming cells various With being proposed developed, can be gradually summarized becomes more clearer. In context many cancer, disease, occurs inducing proinflammatory or anti-inflammatory effects. phenotypic functional changes caused by further affect development Based on experimental results, targeting cellular promising therapy. this review, we focus introduce their pathways reprogramming, summarize how these effects We thoroughly explore targets treatments based existing studies. challenges translating results into clinical applications field are also summarized. believe that better understanding health will improve management most

Language: Английский

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Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 8, 2025

Language: Английский

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Spatiotemporal metabolomic approaches to the cancer-immunity panorama: a methodological perspective

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 18, 2024

Language: Английский

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Metabolic interplays between the tumour and the host shape the tumour macroenvironment

Nature reviews. Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

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Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 22, 2025

Osteosarcoma is the most common malignant bone tumor in children and adolescents, characterized by high disability mortality rates. Over past three decades, therapeutic outcomes have plateaued, underscoring critical need for innovative targets. Solute carrier (SLC) family transporters been implicated progression of a variety tumors, however, their specific role osteosarcoma remains poorly understood. The single-cell sequencing data from GSE152048 GSE162454, along with RNA-seq TARGET GSE21257 cohorts, were utilized analysis this study. LASSO regression was conducted to identify prognostic genes construct an SLC-related signature. Survival ROC evaluated validity ESTIMATE CIBERSORT Packages assess immune infiltration status. Pseudotime CellChat analyses performed investigate relationship between SLC7A1, phenotypes, microenvironment. CCK8 assays, EdU staining, colony formation Transwell co-culture systems used effects SLC7A1 on cell proliferation, metastasis, macrophage polarization. Finally, virtual docking identified potential drugs targeting SLC7A1. SLCs displayed distinct expression patterns across various types within microenvironment, myeloid cells exhibiting preference amino acid uptake. A model comprising nine constructed via regression, showing highest hazard ratio. Multiple analytical algorithms indicated that associated checkpoint gene expression. Single-cell predominantly expressed correlated characteristics. also regulate interactions macrophages, as well modulate function through multiple pathways. In vitro assays survival demonstrated inhibition suppressed phenotype cells, correlating poor prognosis. Co-culture models confirmed involvement screening CETSA Cepharanthine inhibitors signatures can be evaluation osteosarcoma. Pharmacological may feasible approach

Language: Английский

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Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 8, 2025

Epigenomic modifications—such as DNA methylation, histone acetylation, and methylation—and their implications in tumorigenesis, progression, treatment have emerged a pivotal field cancer research. Tumors undergo metabolic reprogramming to sustain proliferation metastasis nutrient-deficient conditions, while suppressing anti-tumor immunity the tumor microenvironment (TME). Concurrently, immune cells within immunosuppressive TME adaptations, leading alterations function. The complicated interplay between metabolites epigenomic modulation has spotlighted significance of regulation immunometabolism. In this review, characteristics modification associated with tumors are systematically summarized alongside regulatory roles Classical emerging approaches delineated broaden boundaries research on crosstalk immunometabolism epigenomics. Furthermore, we discuss potential therapeutic strategies that target modulate modifications, highlighting burgeoning synergy therapies immunotherapy promising avenue for treatment.

Language: Английский

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Recent Progress in Semi‐Implantable Bioelectronics for Precision Health Monitoring

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Abstract Driven by the growing burden of chronic diseases and limited public healthcare resources, portable health monitoring platforms are widely developed to enable continuous timely dissemination provide users with management disease prevention. However, it is still a challenge for precision fully bio‐integrated electronic devices achieve stable physiological signal recording over long periods time. Recently, semi‐implantable bioelectronics (SI‐bioelectronics) have excelled in real‐time, long‐term, high‐sensitivity pathological signals minimal invasiveness, enabled precise microneedle sensing probes. In this review, comprehensive overview recent advancements SI‐bioelectronics provided, focus on their structures, design considerations, performances biochemical indicators, bioelectrical signals, biomechanical signals. Opportunities research such as smart medicine Internet Things also discussed, which will drive toward intelligence efficiency.

Language: Английский

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Recent advances in single-cell metabolomics using mass spectrometry: emerging challenges and future perspectives

Applied Spectroscopy Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 37

Published: April 1, 2025

Language: Английский

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Immune cell infiltration and prognostic index in cervical cancer: insights from metabolism-related differential genes

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 22, 2024

Background Cervical cancer remains a significant gynecologic malignancy in both China and the United States, posing substantial threat to women’s lives health due its high morbidity mortality rates. Altered energy metabolism dysregulated mitochondrial function play crucial roles development, growth, metastasis, recurrence of malignant tumors. In this study, we aimed predict prognosis assess efficacy anti-tumor therapy cervical patients based on differential genes associated with metabolism. Methods Transcriptomic data clinical profiles were retrieved from TCGA GEO databases. Differential gene-related cellular pathways identified through GO, KEGG, GSEA analyses. Prognostic indices constructed using LASSO regression analysis. Immune cell infiltration was assessed CIBERSORT ssGSEA, correlation between immune checkpoint inhibitor examined. Tumor mutation load (TMB) association prognostic analyzed nucleotide variant database. Patient response immunotherapy sensitivity antitumor drugs determined TIDE algorithm oncoPredic algorithm, respectively. Results A index metabolism-related developed outcome patients, enabling their classification into two distinct subtypes. The emerged as an independent risk factor for unfavorable prognosis. high-index group exhibited significantly worse overall prognosis, along elevated tumor burden (TMB), increased infiltration, lower scores, indicating potential benefit immunotherapy. Conversely, low-index demonstrated agents, specifically multikinase inhibitors. Conclusion aim study develop metabolism, which could be used patients’ prognoses. When combined TMB analyses, offers insights landscape, well targeted therapy. Our analysis suggests that Iron-Sulfur Cluster Assembly Enzyme (ISCU) gene holds promise biomarker

Language: Английский

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Molecular Mechanism for Malignant Progression of Gastric Cancer within the Tumor Microenvironment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11735 - 11735

Published: Oct. 31, 2024

Gastric cancer (GC) is one of the most common cancers worldwide. Most patients are diagnosed at progressive stage GC, and progress in development effective anti-GC drugs has been insufficient. The tumor microenvironment (TME) regulates various functions cells, interactions between cellular molecular components TME-e.g., inflammatory fibroblasts, vasculature innate adaptive immune cells-promote aggressiveness cells dissemination to distant organs. This review summarizes roles TME molecules regulating malignant progression metastasis GC. We also address important signaling pathways mediating interaction different GC TME. Finally, we discuss implications these mechanisms for developing novel therapies targeting control

Language: Английский

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