Biomarkers,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 14
Published: Nov. 18, 2024
The
current
study
aimed
to
determine
the
roles
of
pivotal
and
novel
lncRNAs
associated
with
cell
cycle
in
occurrence
development
Colorectal
cancer
(CRC).
To
achieve
this,
TCGA-COAD
project
related
CRC
was
downloaded,
differential
expression
analysis
performed
identify
differentially
expressed
lncRNAs,
miRNAs,
mRNAs.
A
cycle-associated
lncRNA-miRNA-mRNA
regulatory
network
constructed,
two
were
selected.
Two
subnetworks
constructed
for
selected
lncRNAs.
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
enrichment
analyses
illustrated
genes
each
sub-network.
qPCR
used
validate
levels
tissues
compared
those
adjacent
normal
tissues.
identified
416
317
117
ceRNA
subnetwork
different
pathways,
including
cellular
senescence,
DNA
replication,
human
T-cell
leukemia
virus
1
infection,
oocyte
meiosis.
bioinformatic
results
based
on
TCGA
indicated
dysregulation
MIR29B2CHG
HELLPAR,
Moreover,
confirmed
ROCs
curves
revealed
that
both
had
acceptable
specificity
sensitivity
as
biomarkers.
In
conclusion,
have
potential
be
understood
underlying
molecular
mechanisms
influence
CRC.
Therefore,
these
can
considered
promising
biomarkers
diagnosis
treatment
Exploration of Medicine,
Journal Year:
2025,
Volume and Issue:
6
Published: April 28, 2025
The
interaction
between
cancer
and
coronavirus
disease
2019
(COVID-19)
poses
significant
challenges,
particularly
for
immunocompromised
individuals
who
are
at
heightened
risk
acute
infections
long-term
complications.
pandemic
has
exacerbated
existing
vulnerabilities
in
care
by
disrupting
treatment
protocols
delaying
diagnoses,
leading
to
worsened
health
outcomes.
This
article
emphasizes
the
importance
of
investigating
potential
impact
severe
respiratory
syndrome
2
(SARS-CoV-2)
on
progression
highlights
need
effective
strategies
protect
this
high-risk
population.
Long-term
consequences,
including
emergence
long
COVID,
further
emphasize
ongoing
surveillance
comprehensive
healthcare
planning
patients
during
after
pandemics.
A
multifaceted
approach
is
essential,
incorporating
vaccination,
timely
therapeutic
interventions,
sustained
support
with
lingering
symptoms.
also
discusses
urges
continued
research
into
oncogenic
risks
associated
SARS-CoV-2,
which
crucial
enhancing
our
understanding
broader
implications
COVID-19
informing
public
aimed
safeguarding
future
Moreover,
data
collection
development
refined
clinical
guidelines
vital
improving
patient
outcomes
preparing
systems
crises.
Additionally,
mechanisms
SARS-CoV-2
may
increase
susceptibility,
chronic
inflammation,
cellular
senescence,
immune
dysregulation.
Understanding
these
elucidating
virus’s
potential,
among
survivors
infections.
Ensuring
continuity
resilience
global
crises
requires
mitigate
disruptions,
enhance
access
screenings
treatments,
address
specific
challenges
faced
experiencing
COVID.
Aging advances.,
Journal Year:
2024,
Volume and Issue:
1(2), P. 118 - 134
Published: Dec. 1, 2024
Aging
is
a
complex
biological
process
characterized
by
gradual
deterioration
in
physiological
activities,
contributing
to
an
elevated
risk
of
different
age-associated
malignancies,
including
cancer.
The
current
review
paper
aims
elucidate
the
association
between
hallmarks
aging
and
parallel
development
Various
cellular
molecular
mechanisms
underlying
such
as
senescence,
genomic
instability,
telomere
shortening
play
significant
role
accumulation
genetic
mutations
disruption
activities.
It
has
also
discussed
immune
system’s
aging,
indicating
how
age-linked
dysfunction
compromises
body’s
capacity
recognize
eradicate
pre-tumorous
cells,
thus
promoting
cancer
advancement.
This
examines
affects
tumor
microenvironment,
where
age-related
alterations
stromal
extracellular
matrix
factors
lead
conditions
that
promote
growth
proliferation.
Furthermore,
it
discusses
concept
“accelerated
aging”
survivors,
highlighting
negative
effects
its
therapy
intensify
process,
resulting
greater
physical
cognitive
decline.
explores
prospect
new
therapies
target
aging-related
processes
ameliorate
outcomes.
Overall,
underscores
need
for
ongoing
interdisciplinary
research
understand
relationship
cancer,
ultimately
aiming
develop
more
effective
prevention
treatment
approaches.
Biomarkers,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 14
Published: Nov. 18, 2024
The
current
study
aimed
to
determine
the
roles
of
pivotal
and
novel
lncRNAs
associated
with
cell
cycle
in
occurrence
development
Colorectal
cancer
(CRC).
To
achieve
this,
TCGA-COAD
project
related
CRC
was
downloaded,
differential
expression
analysis
performed
identify
differentially
expressed
lncRNAs,
miRNAs,
mRNAs.
A
cycle-associated
lncRNA-miRNA-mRNA
regulatory
network
constructed,
two
were
selected.
Two
subnetworks
constructed
for
selected
lncRNAs.
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
enrichment
analyses
illustrated
genes
each
sub-network.
qPCR
used
validate
levels
tissues
compared
those
adjacent
normal
tissues.
identified
416
317
117
ceRNA
subnetwork
different
pathways,
including
cellular
senescence,
DNA
replication,
human
T-cell
leukemia
virus
1
infection,
oocyte
meiosis.
bioinformatic
results
based
on
TCGA
indicated
dysregulation
MIR29B2CHG
HELLPAR,
Moreover,
confirmed
ROCs
curves
revealed
that
both
had
acceptable
specificity
sensitivity
as
biomarkers.
In
conclusion,
have
potential
be
understood
underlying
molecular
mechanisms
influence
CRC.
Therefore,
these
can
considered
promising
biomarkers
diagnosis
treatment
