Cells,
Journal Year:
2024,
Volume and Issue:
13(23), P. 1935 - 1935
Published: Nov. 21, 2024
Hepatobiliary
cancers,
such
as
hepatocellular
carcinoma
(HCC)
and
cholangiocarcinoma
(CCA),
are
among
the
deadliest
malignancies
worldwide,
leading
to
a
significant
number
of
cancer-related
deaths.
While
bone
metastases
from
these
cancers
rare,
they
highly
aggressive
linked
poor
prognosis.
This
review
focuses
on
RNA-based
molecular
mechanisms
that
contribute
metastasis
hepatobiliary
cancers.
Specifically,
role
two
key
factors,
microRNAs
(miRNAs)
RNA-binding
proteins
(RBPs),
which
have
not
been
extensively
studied
in
context
HCC
CCA,
is
discussed.
These
molecules
often
exhibit
abnormal
expression
tumors,
influencing
cancer
cell
spread
by
disrupting
homeostasis,
thereby
aiding
tumor
migration
survival
microenvironment.
also
discusses
potential
therapeutic
strategies
targeting
pathways
reduce
improve
patient
outcomes.
Further
research
crucial
for
developing
effective
miRNA-
RBP-based
diagnostic
prognostic
biomarkers
treatments
prevent
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Abstract
Methods
The
ethanolic
roots
(CCRE)
and
leaves
(CCLE)
extracts
were
interrogated
for
their
apoptotic
potential
against
human
lung
adenocarcinoma
cell
line
(A549)
using
DNA
fragmentation,
Annexin
V-FITC/PI
staining
apoptosis
assay
cycle
analysis
flow
cytometry.
Results
Our
results
revealed
significant
damage
induced
death
in
A549
on
treatment
with
active
concentrations
(40
µg/ml
80
µg/ml)
of
the
S
phase
arrest.
Conclusions
This
is
first
study
demonstrating
inducing
chemically
characterized
bioactive
compounds
present
from
Chlorophytum
comosum
non-small
line.
concludes
that
can
be
a
candidate
natural
isolated,
clinically
evaluated
development
novel
naturally
derived
anti-cancer
drugs
cancer.
Life,
Journal Year:
2025,
Volume and Issue:
15(3), P. 396 - 396
Published: March 3, 2025
Metastasis
remains
the
leading
cause
of
death
among
patients
with
non-small
cell
lung
cancer
(NSCLC),
emphasizing
urgent
need
for
safer
and
more
effective
therapeutic
options.
Mitogen-activated
protein
kinase
(MAPK)
pathways
play
a
crucial
role
in
regulating
EMT,
migration,
invasion
NSCLC.
Targeting
these
molecular
mechanisms
has
become
key
strategy
inhibiting
NSCLC
metastasis.
Loureirin
A
B,
flavonoids
derived
from
Thai
traditional
herb
Dracaena
loureiri,
have
shown
potential
pharmacological
effects;
however,
their
roles
metastasis
remain
unexplored.
This
study
aimed
to
elucidate
by
which
B
suppress
cells
via
MAPK
signaling
pathway.
The
sulforhodamine
(SRB)
assay
showed
that
at
concentrations
ranging
0
140
μM,
were
non-toxic
both
A549
H1299
cells.
Additionally,
Loureirins
exhibited
no
cytotoxic
effects
on
primary
human
dermal
fibroblast
did
not
induce
hemolysis
red
blood
(RBCs).
wound-healing
trans-well
assays
used
evaluate
anti-migratory
anti-invasion
properties
lines.
Gelatin
zymography
was
employed
investigate
activity
MMP-2
(gelatinase
A)
MMP-9
B),
while
Western
blot
analysis
examine
expression
EMT
markers
invasive
proteins,
phosphorylation
molecules.
Our
results
demonstrate
significantly
suppressed
migration
These
compounds
matrix
metalloproteinases
downregulated
proteins
including
uPA,
uPAR,
MT1-MMP.
they
effectively
such
as
N-cadherin,
Vimentin,
Fibronectin.
Mechanistically,
inhibited
pathway
downregulating
ERK,
JNK,
p38
proteins.
In
conclusion,
findings
exhibit
potent
anti-invasive
effect
lines,
suggesting
promising
candidates
anti-cancer
drug
development.
Furthermore,
may
pave
way
exploration
combination
therapies
other
drugs
clinical
translation.
Pharmacological Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107733 - 107733
Published: April 1, 2025
Hepatocellular
carcinoma
(HCC),
originating
from
hepatocytes,
is
the
most
common
type
of
primary
liver
cancer.
HCC
imposes
a
significant
global
health
burden
with
high
morbidity
and
mortality,
making
it
critical
public
concern.
Surgical
interventions,
including
hepatectomy
transplantation,
are
pivotal
in
achieving
long-term
survival
for
patients
HCC.
Additionally,
ablation
therapy,
endovascular
interventional
radiotherapy,
systemic
anti-tumor
therapies
commonly
employed.
However,
these
treatment
modalities
often
associated
considerable
challenges,
postoperative
recurrence
rates
adverse
effects.
Traditional
Chinese
medicine
(TCM)
natural
products
have
been
utilized
centuries
as
complementary
approach
managing
its
complications,
demonstrating
favorable
clinical
outcomes.
Various
bioactive
compounds
derived
TCM
identified
purified,
their
mechanisms
action
extensively
investigated.
This
review
aims
to
provide
comprehensive
up-to-date
evaluation
efficacy
TCM,
active
constituents
management
Particular
emphasis
placed
on
elucidating
potential
molecular
therapeutic
targets
agents,
roles
inhibiting
cell
proliferation,
inducing
apoptosis
pyroptosis,
suppressing
tumor
invasion
metastasis,
restraining
angiogenesis
within
tissues.
