Folic Acid-Targeted Mixed Pluronic Micelles for Delivery of Triptolide DOI Open Access
Meizhen Yin, Xinying Zhang,

T.Y. Zhang

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(24), P. 3485 - 3485

Published: Dec. 13, 2024

The present study aimed to explore an ideal delivery system for triptolide (TPL) by utilizing the thin-film hydration method prepare drug-loaded, folate-modified mixed pluronic micelles (FA–F-127/F-68–TPL). Scanning electron microscopy and atomic force showed that drug-loaded had a spherical shape with small particle size, average of 30.7 nm. Cell viability experiments FA–F-127/F-68–TPL significantly reduced HepG2 cell viability, exhibiting strong cytotoxicity. Its cytotoxicity was markedly enhanced compared bare TPL. Nile red (Nr) used as model drug FA–F-127/F-68–Nr further validate its tumor-targeting cellular uptake capability. After coincubation cells, multifunctional microplate reader intracellular fluorescence intensity increased, indicating could more effectively enter cells. A nude mouse subcutaneous hepatocellular carcinoma constructed. Following tail vein injection FA–F-127/F-68–Nr, imaging FA–F127/F-68–Nr target tumor tissue, even if entering small-sized challenging, it be excreted through urine. Nude mice were treated injections (45 µg/kg) every other day 21 days. results growth transplanted tumors slowed, no significant difference In summary, exhibits advantages low cost, excellent biological properties, active/passive targeting capabilities, notable against liver cancer inhibition growth. Significantly, FA–F-127/F-68–TPL, despite challenges in insignificant EPR effect, can efficiently via kidneys, thereby preventing release during prolonged circulation potential damage normal tissues. Therefore, represents promising antitumor system.

Language: Английский

Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts DOI Creative Commons

Zhongsong Zhang,

Long Chen

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

Citations

2
Combined Albumin Polyester Nanocarriers with Docetaxel for Effective Against Lung Cancer in Mice Model DOI Creative Commons

Yixiao Yang,

Ye Tao, Fusheng Shang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2103 - 2118

Published: Feb. 1, 2025

Lung cancer, a deadly malignancy, often employs Docetaxel (DTX) as chemotherapy option. However, DTX non-selective distribution limits its therapeutic effectiveness due to adverse side effects. This study aims develop novel folate-targeted albumin polyester nanocarriers (FA-DTX-APs) encapsulating for precise delivery, enhancing lung cancer treatment efficacy. FA-DTX-APs were meticulously crafted utilizing the thin-film dispersion technique and subsequently evaluated their physicochemical characteristics, encapsulation efficiency, drug release profiles. To assess biological properties, anti-tumor efficacy, biosafety in context of comprehensive series hemolysis assays, cellular studies, animal experiments conducted. exhibit nanovesicle properties with size (223.65 ± 6.83) nm, potential (26.76 3.15) mV, encapsulate high efficiency (96.19 3.27%) loading capacity (9.75 0.38%). enable tumor-targeted delivery slow over long period time, faster acidic environments. By efficiently targeting entering cells, effectively hinder growth (P < 0.05), demonstrating superior effects biocompatibility enhanced safety 0.05). introduces FA-DTX-APs, an innovative nanocarrier characterized by exceptional safety. It successfully targets cells deliver sustained, slow-release manner, ensuring prolonged tumor-killing As such, hold immense promise nanoagent therapy.

Language: Английский

Citations

2
Synthesis, Characterization of Chitosan Nanoparticles from Cuttlebone of Sepia prashadi and Its Anticancer Efficacy Against MG63 Cell Line DOI

Chithambara Shathviha Palaniappan,

Annathai Pitchai,

Revathi Duraisamy

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 1, 2025

Language: Английский

Citations

1
Mirvetuximab Soravtansine Induces Potent Cytotoxicity and Bystander Effect in Cisplatin-Resistant Germ Cell Tumor Cells DOI Creative Commons
Lucia Kučerová,

Adriana Fekiačová,

Natália Udvorková

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(4), P. 287 - 287

Published: Feb. 15, 2025

Patients with treatment-refractory/relapsing germ cell tumors (GCTs) have a dismal prognosis due to lack of any effective therapy. Moreover, the efficacy newly approved targeted therapies remains unexplored for cisplatin-resistant GCTs. Previously, it was demonstrated that folate receptor α (FRα) is overexpressed in many tumor types and efficiently by antibody-drug conjugate (ADC) mirvetuximab soravtansine (MIRV) cancers. We hypothesized FRα represents an attractive target treating treatment-refractory determined expression FOLR1 gene broad range GCT lines xenografts. tested antitumor MIRV on cells vitro explored ability treatment induce bystander effect direct coculture FRα-high FRα-low cells. found has significantly higher testicular GCTs (TGCTs) than normal tissue. highly expressed TCam2, JEG3, JAR, NOY1 their respective variants. induced apoptosis potent antiproliferative adherent 3D spheroid cultures vitro. A significant decrease 2102EP_R_NL observed presence NOY1_R_SK 12.5 nM MIRV, showing coculture. Immunohistochemical analysis confirmed Folr1 protein patients TGCTs postchemotherapy chemo-naïve patients, as well unfavorable prognosis. In this study, we present data suggesting (T)GCT vivo, anti-FRα-targeting should be investigated modality subset TGCTs. effects, thus its potential further preclinical exploration drug repurposing salvage regime refractory disease.

Language: Английский

Citations

0
Chitosan and Its Derivatives as Nanocarriers for Drug Delivery DOI Creative Commons
Ranu Biswas,

Sourav Mondal,

Md Ahesan Ansari

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1297 - 1297

Published: March 13, 2025

Chitosan (CS) occurs naturally as an alkaline polysaccharide and has been demonstrated to have several activities of a biological nature. Additionally, CS chains functional hydroxyl amino groups that are active, their applications can be expanded by chemically or molecularly altering the molecules incorporate new groups. Due its outstanding qualities, including biodegradability, biocompatibility, non-toxicity, accessibility, it received significant interest in all areas biomedicine nanomaterials being extremely promising drug nanocarrier. The last decades produced lot CS-based nanoparticles (CSNPs), with increasing number research papers from around 1500 2015 almost 5000 2024. degree crosslinking, particulate system’s shape, size, density, addition drug’s physical chemical properties, role how is transported released CSNPs. When creating potential delivery systems based on CSNPs, these factors must considered. In earlier, CSNPs were employed enhance pharmacotherapeutics, pharmacokinetics, solubility properties drugs. By investigating positively charged characteristics changeable groups, evolved into versatile system. release will definitely influenced various changes charges, polymer backbone. This review mainly discusses most important results published decade. Despite advantages challenges related translation clinical stages remain further vitro vivo studies mandatory.

Language: Английский

Citations

0
Pancreatic cancer: failures and hopes—a review of new promising treatment approaches DOI Creative Commons
Vittore Cereda, Mario D’Andrea

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: 6

Published: March 18, 2025

Pancreatic cancer is a challenging disease with limited treatment options and high mortality rate. Just few therapy advances have been made in recent years. Tumor microenvironment, immunosuppressive features mutational status represent important obstacles the improvement of survival outcomes. Up to now, first-line did achieve median overall less than 12 months this discouraging data lead clinicians all over world focus their efforts on various fields investigation: 1) sequential cycling different systemic order overcome mechanisms resistance; 2) discovery new predictive bio-markers, target specific patient population; 3) combination treatment, modulate tumor microenvironment pancreatic cancer; 4) modalities delivery drugs pass physical barrier desmoplasia stroma. This review shows future directions strategies advanced through deep analysis these macro areas research.

Language: Английский

Citations

0
Research Progress on Graphene Oxide (GO)/Chitosan (CS) Multifunctional Nanocomposites for Drug Delivery DOI Creative Commons
Yanqiu Hu, Лей Ма, Qi Shi

et al.

Inorganics, Journal Year: 2025, Volume and Issue: 13(4), P. 98 - 98

Published: March 21, 2025

With the unprecedented progress of biomedical nanotechnology in past few decades, traditional drug delivery systems (DDSs) have been incorporated into intelligent DDSs with stimulus responsive characteristics. Graphene oxide (GO) and Chitosan (CS) excellent physical, chemical, mechanical, optical properties, their synergistic effects attracted widespread attention field. In this review, we focus on physicochemical characteristics GO, CS, GO/CS composites, as well research DDS types based GO/CS.

Language: Английский

Citations

0
Smart Drug Delivery Systems Based on Cyclodextrins and Chitosan for Cancer Therapy DOI Creative Commons

Larisa Păduraru,

Alina Diana Panainte, Cătălina A. Peptu

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 564 - 564

Published: April 13, 2025

Despite improvements in therapeutic approaches like immunotherapy and gene therapy, cancer still remains a serious threat to world health due its high incidence mortality rates. Limitations of conventional therapy include suboptimal targeting, multidrug resistance, systemic toxicity. A major challenge current oncology therapies is the development new delivery methods for antineoplastic drugs that act directly on target. One approach involves complexation antitumor with cyclodextrins (CDs) chitosan (CS) as an attempt counteract their primary limitations: low water solubility bioavailability, diminished vitro vivo stability, dose-dependent All those drawbacks may potentially exclude some candidates from clinical trials, thus integration into smart systems or drug-targeting technologies must be implemented. We intended overview drug based regard diagnosis management. This narrative review encompasses full-length articles published English between 2019 2025 (including online ahead print versions) PubMed-indexed journals, focusing recent research encapsulation diverse within nanosystems exhibit responsiveness various stimuli such pH, redox potential, folate receptor levels, thereby enhancing release bioactive compounds at tumor sites. The majority cited references focus most notable research, studies novel applications, scientific advancements field nanostructures functional materials employed oncological over last six years. Certainly, there are additional potential can facilitate drug’s upon activation, reactive oxygen species (ROS), enzymes, ATP level, hypoxia; however, our exclusively addresses aforementioned presented comprehensive manner.

Language: Английский

Citations

0
Chitosan Nanoparticles: Approaches to Preparation, Key Properties, Drug Delivery Systems, and Developments in Therapeutic Efficacy DOI
Wasfy M. Obeidat,

Ishraq K. Lahlouh

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(5)

Published: April 17, 2025

Language: Английский

Citations

0
Synthesis and Characterization of Iron Oxide-Thalidomide Nanoconjugates for Enhanced Anti-Inflammatory Activities DOI

Anoosha Sajjad,

R. A. Manzoor,

Anila Sajjad

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142454 - 142454

Published: April 1, 2025

Language: Английский

Citations

0