The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment DOI Open Access
Hui Lyu,

Jinghua Kong,

Jiasi Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13334 - 13334

Published: Dec. 12, 2024

Pancreatic cancer remains one of the most lethal forms cancer. Currently, there is a lack effective drug treatments for pancreatic However, as newly discovered form non-apoptotic cell death, ferroptosis has garnered increasing attention in relation to Understanding role tumorigenesis and treatment may enable more clinical trials minimize side effects or restrict emergence resistance. In this review, we summarize current knowledge regarding process underlying mechanisms ferroptosis, well its dual both promoting facilitating strategies Additionally, how implicated development pancreatitis insulin resistance, indicating that play an important risk pancreatitis- insulin-resistance-related cancers, also addressed.

Language: Английский

Leveraging Immunogenic Cell Death to Enhance the Immune Response against Malignant Pleural Mesothelioma Tumors DOI Creative Commons
Meng Rui Chang,

Egor M. Matnurov,

Chengnan Wu

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(9), P. 7908 - 7920

Published: Feb. 24, 2025

Although various metal-based compounds have exhibited excellent immunogenic cell death (ICD)-inducing properties both in vitro and vivo, the majority of these been discovered serendipitously. In this work, we successfully synthesized characterized 35 cyclometalated Au(III) complexes containing dithiocarbamate ligands, with 25 being previously unreported. Their ability to induce phagocytosis against immunologically "cold" malignant pleural mesothelioma (MPM) cells was strongly dependent on scaffold overall lipophilicity complexes. We elucidated role mechanisms observed ICD effects identified correlations between necrotic ICD, vivo. Complex 2G, its high rates low necrosis rates, recognized as a bona fide inducer, demonstrating remarkably long-lasting immune response vaccinated mice. contrast, complex 1C, by failed elicit sustained upon following vaccination; however, it triggered selective activation calreticulin tumors direct vivo administration. Overall, study offers framework for predicting structurally similar complexes, potential extension other series metal

Language: Английский

Citations

2
Exploring molecular disparities of H-type vasculature endothelial cells in osteonecrosis of the femoral head through single-cell analysis DOI Creative Commons
Shi Wei, Dong Li, Qian Xu

et al.

BMC Musculoskeletal Disorders, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 6, 2025

Recent studies highlight the role of H-type vasculature in bone regeneration. This study, based on single-cell RNA sequencing (scRNA-seq), aims to explore changes endothelial cells (H_ECs) osteonecrosis femoral head (ONFH) and hip osteoarthritis (HOA), focusing death modes such as ferroptosis, pyroptosis, parthanatos. We re-analyzed scRNA-seq data samples publicly available 2022. study selected nine (3 each from HOA, ONFH stage 3 A, 4). CD31 + EMCN were classified H_ECs. Molecular differences assessed using Gene Ontology KEGG analysis. Hypoxia, parthanatos indices calculated, transcription factors predicted SENIC. Cell communication was analyzed with CellChat. After integrating 9 samples, 14 cell types identified: B cells, Mesenchymal stem Osteoblasts, Endothelial Monocytes, T NK Fibroblasts, Macrophages, Common myeloid progenitors, Chondrocytes, Myelocytes, Osteoclasts, Pericytes. The number H_ECs decreased necrosis severity. showed higher angiogenic capacity but lower stress resistance compared other cells. Angiogenic necrotic accompanied by an elevation inflammation levels. hypoxia index higher, ferroptosis increased A stages 4. No change observed pyroptosis. analysis revealed downregulation SLIT3-ROBO4 signaling during necrosis. show molecular Ferroptosis contribute demise ONFH, pericytes fibroblasts supporting H_EC angiogenesis.

Language: Английский

Citations

0
Network pharmacology and in silico approach to study the mechanism of quercetin against breast cancer DOI
Tejveer Singh,

Mukund Rastogi,

Kulbhushan Thakur

et al.

In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 6, 2025

Language: Английский

Citations

0
Insulin-induced gene 2 alleviates ischemia-reperfusion injury in steatotic liver by inhibiting GPX4-dependent ferroptosis DOI Creative Commons
Yichao Wu, Changbiao Li, Di Lu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 1, 2025

Abstract Hepatic steatosis significantly elevates the vulnerability of graft to ischemia-reperfusion (I/R) injury during liver transplantation (LT). We investigated protective role insulin-induced gene 2 (Insig2) in steatotic liver’s I/R and underlying mechanisms. Employing mouse model with Insig2 knock-out or hepatocyte-specific overexpression high-fat diets induce steatosis, we subjected these mice hepatic injury. The primary hepatocytes isolated from were used vitro hypoxia/reoxygenation (H/R) experiment. Our integrated vivo approach uncovered that deficiency exacerbated damage following injury, whereas its offers protection. Mechanically, integrative analysis transcriptome, proteome, metabolome found disturbed lipid metabolism oxidative stress homeostasis, particularly inhibiting GPX4 expression ferroptosis. Furthermore, chemical inhibition ferroptosis reversed deleterious effect deficiency; influence was negated by target GPX4, leading an exacerbation damage. These insights underscored potential Insig2-GPX4 axis as a therapeutic target, presenting novel avenue for enhancing resilience grafts against

Language: Английский

Citations

0
The function of necroptosis in liver cancer DOI

Mukaddas Tayir,

Yanwen Wang,

Ti Chu

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 167828 - 167828

Published: April 1, 2025

Language: Английский

Citations

0
The role of nutrition in cancer prevention: the effect of dietary patterns, bioactive compounds, and metabolic pathways on cancer development DOI Creative Commons
Sebastián Chapela,

Julieta Locatelli,

Facundo Saettone

et al.

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: April 17, 2025

Language: Английский

Citations

0
Caspase-independent cell death in lung cancer: from mechanisms to clinical applications DOI Creative Commons
Gaurav Gupta,

Vijaya Paul Samuel,

M M Rekha

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Abstract Caspase-independent cell death (CICD) has recently become a very important mechanism in lung cancer, particular, to overcome critical failure apoptotic that is common disease progression and treatment failures. The pathways involved CICD span from necroptosis, ferroptosis, mitochondrial dysfunction, autophagy-mediated death. Its potential therapeutic applications have been highlighted. Glutathione peroxidase 4 (GPX4) inhibition-driven ferroptosis drug resistance non-small cancer (NSCLC). In addition, necroptosis involving RIPK1 RIPK3 causes tumor modulation of immune responses the microenvironment (TME). Mitochondrial are for through metabolic redox homeostasis. Ferroptosis amplified by reactive oxygen species (ROS) lipid peroxidation cells, depolarization induces oxidative stress leads mitochondria-mediated autophagy, or mitophagy, results clearance damaged organelles under conditions, while this function also linked when dysregulated. role autophagy regulated ATG proteins PI3K/AKT/mTOR pathway dual: suppress sensitize cells therapy. A promising approach enhancing outcomes involves targeting mechanisms CICD, including inducing SLC7A11 inhibition, modulating ROS generation, combining inhibition with chemotherapy. Here, we review molecular underpinnings particularly on their transform treatment.

Language: Английский

Citations

0
PANoptosis: a potential target of atherosclerotic cardiovascular disease DOI Creative Commons

Xiao Jin,

Yanan Zhu,

Lina Xing

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

PANoptosis is a newly discovered cell death pathway triggered by the innate immunizer, which in turn promotes assembly of PANoptosome and activates downstream effectors. As special mode, it characterized apoptosis, pyroptosis, necroptosis at same time; therefore, not feasible to inhibit suppressing single pathway. However, active ingredients targeting can effectively PANoptosis.Given importance disease, would be an important therapeutic tool. Previous studies have focused more on infectious diseases cancer, role cardiovascular field has been comprehensively addressed. While ASCVD number one killer diseases, explore new targets determine future research directions. Therefore, this review focuses PANoptosome, molecular mechanism PANoptosis, related mechanisms leading such as myocardial infarction, ischemic cardiomyopathy stroke, order provide perspective for prevention treatment ASCVD.

Language: Английский

Citations

0
The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment DOI Open Access
Hui Lyu,

Jinghua Kong,

Jiasi Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13334 - 13334

Published: Dec. 12, 2024

Pancreatic cancer remains one of the most lethal forms cancer. Currently, there is a lack effective drug treatments for pancreatic However, as newly discovered form non-apoptotic cell death, ferroptosis has garnered increasing attention in relation to Understanding role tumorigenesis and treatment may enable more clinical trials minimize side effects or restrict emergence resistance. In this review, we summarize current knowledge regarding process underlying mechanisms ferroptosis, well its dual both promoting facilitating strategies Additionally, how implicated development pancreatitis insulin resistance, indicating that play an important risk pancreatitis- insulin-resistance-related cancers, also addressed.

Language: Английский

Citations

0