Metal nanoparticles as a promising therapeutic approach for prostate cancer diagnosis and therapy: a comprehensive review

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: Feb. 23, 2025

Language: Английский

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Exosomal Dynamics: Bridging the Gap Between Cellular Senescence and Cancer Therapy

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: 225, P. 112045 - 112045

Published: March 11, 2025

Cancer remains one of the most devastating diseases, severely affecting public health and contributing to economic instability. Researchers worldwide are dedicated developing effective therapeutics target cancer cells. One promising strategy involves inducing cellular senescence, a complex state in which cells exit cell cycle. Senescence has profound effects on both physiological pathological processes, influencing systems through secreted factors that affect surrounding distant Among these exosomes, small extracellular vesicles play crucial roles communication, development, defense, can contribute conditions. Recently, there been increasing interest engineering exosomes as precise drug delivery vehicles, capable targeting specific or intracellular components. Studies have emphasized significant role from senescent progression therapy. Notably, chemotherapeutic agents alter tumor microenvironment, induce trigger immune responses exosome-mediated cargo transfer. This review explores intricate relationship between cancer, examining how different eliminate promote resistance. It also investigates molecular mechanisms signaling pathways driving highlighting current challenges proposing future perspectives uncover new therapeutic strategies for treatment.

Language: Английский

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Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 2, 2025

The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides comprehensive review of methodologies for evaluating including handheld dynamometry, advanced imaging techniques, electrical impedance myography, elastography, single-fiber experiments to assess quality performance. Furthermore, it elucidates mechanisms, applications, limitations various modalities, immune checkpoint inhibitors, adoptive cell therapy, cancer vaccines, combined chemoimmunotherapy, while examining their effects on function systemic responses. Key findings indicate that although is effective in augmenting antitumor immunity, frequently induces muscle-related adverse such as weakness, fatigue, or damage, primarily mediated by cytokine release activation. underscores significance niches within microenvironment influencing treatment outcomes proposes strategies optimize therapy through personalized regimens combinatorial approaches. highlights need further formation interactions muscle-tumor. Our crucial advancing efficacy immunotherapy, reducing effects, ultimately improving survival rates life patients with cancer.

Language: Английский

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Novel bioengineered drugs with immunotherapies for malignant pleural effusion: remodulate tumor immune microenvironment and activate immune system

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104717 - 104717

Published: April 1, 2025

Language: Английский

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Neoantigen vaccines: advancing personalized cancer immunotherapy

Exploration of Immunology, Journal Year: 2025, Volume and Issue: 5

Published: April 8, 2025

Neoantigen vaccines are a promising strategy in cancer immunotherapy that leverage tumor-specific mutations to elicit targeted immune responses. Although they have considerable potential, development challenges related antigen prediction accuracy, manufacturing complexity, and scalability remain key obstacles their widespread clinical use. This literature review was conducted using PubMed, Scopus, Web of Science, Google Scholar databases identify relevant studies. Keywords included “neoantigen vaccines,” “personalized immunotherapy,” “tumor heterogeneity,” “bioinformatics pipelines,” “prediction algorithms”. Clinical trial data were sourced from ClinicalTrials.gov, Trialtrove, other publicly available registries. Eligible studies peer-reviewed research articles, systematic reviews, trials focusing on neoantigen vaccine development, bioinformatic strategies, immunotherapy. Tumor heterogeneity clonal evolution significantly impact efficacy, necessitating multi-epitope targeting adaptive design. Current algorithms suffer high false-positive false-negative rates, requiring further integration with multi-omics machine learning enhance accuracy. Manufacturing remains complex, time-intensive, costly, advancements standardization automation. Combination therapies, such as checkpoint inhibitors adoptive cell counteract the immunosuppressive tumor microenvironment, improving treatment outcomes. hold great potential for personalized therapy but require bioinformatics, scalability, immunomodulatory strategies efficacy. Continued interdisciplinary collaboration essential refining applications.

Language: Английский

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Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101782 - 101782

Published: April 1, 2025

Language: Английский

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