Nanoengineered Copper: Revolutionizing Breast Cancer Care

International Journal of Scientific Research in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 12(1), P. 164 - 180

Published: Feb. 3, 2025

Breast cancer continues to rank as a predominant cause of illness and death among women globally, emphasizing the critical need for innovative effective treatment approaches. Traditional methods such chemotherapy, surgery, radiation therapy often face limitations, including toxicity, resistance, non-specific targeting. In recent years, advancements in nanotechnology have brought about transformative solutions, with nanoengineered copper emerging frontrunner. Nanoengineered copper’s unique properties- its catalytic capabilities, biocompatibility, potential surface modification- offer unprecedented opportunities revolutionize breast care. These nanoparticles not only enable precise targeting cells but also improve diagnostic accuracy through advanced imaging techniques. Furthermore, their application photothermal photodynamic therapies provides dual approach destroying while minimizing harm healthy tissues. With ability modulate tumor microenvironment act platform combination therapies, holds immense promise both early detection treatment. This article explores wide-ranging applications copper, from innovations therapeutic breakthroughs, underscoring redefine management patient outcomes.

Language: Английский

Gambogic Acid Based Coordination Polymer Reinforces High‐Intensity Focused Ultrasound Treatment of Gynecologic Malignancies

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract High‐intensity focused ultrasound (HIFU) is emerging as a promising non‐invasive treatment for solid tumors. Nevertheless, HIFU may also induce the upregulation of Heat Shock Protein 90 (HSP‐90), potentially resulting in resistance to HIFU. Besides, although it effective against situ tumors, challenges remain with tumor metastasis and recurrence. Herein, innovative design gambogic acid (GA) based coordination polymer—GAZn‐PEG nanoparticles (GAZn‐PEG NPs) are synthesized through GA zinc ions (Zn 2+ ), subsequently functionalized lipid bilayer incorporating polyethylene glycol (PEG), sensitizing cervical ovarian cancers. Briefly, under exposure, markedly suppresses expression HSP‐90, thereby increasing tumor's sensitivity therapy. Furthermore, Zn not only overcome issue GA's poor water solubility but synergistically stimulate immune responses conjunction GA. More intriguingly, has been discovered that GAZn‐PEG can effectively activate cyclic GMP‐AMP synthase‐stimulator interferon genes (cGAS‐STING) pathway, enhancing provoked by Specifically, NPs show remarkable increase dendritic cell activation stimulation cGAS‐STING crucial long‐term protection recurrence metastasis.

Language: Английский