Epigenetic Control of Alveolar Macrophages: Impact on Lung Health and Disease DOI Creative Commons
Nirmal Parajuli, Kalpana Subedi, Xzaviar Kaymar Solone

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 640 - 640

Published: April 25, 2025

Alveolar macrophages (AMs) are immune cells located in the alveoli—the tiny air sacs lungs where gas exchange occurs. Their functions regulated by various epigenetic mechanisms, which essential for both healthy lung function and disease development. In lung’s microenvironment, AMs play critical roles surveillance, pathogen clearance, tissue repair. This review examines how regulation influences AM their involvement diseases. Key such as DNA methylation, histone modifications, non-coding RNAs, regulate gene expression response to environmental signals. lungs, these modifications enable quickly respond inhaled threats. However, when processes malfunction, they could contribute diseases pulmonary fibrosis, COPD, hypertension. By exploring changes affect polarization, plasticity, responses, we can gain deeper insights into role open new avenues treating preventing respiratory conditions. Ultimately, understanding mechanisms within enhances our knowledge of immunology offers potential innovative interventions restore health prevent

Language: Английский

Epigenetic Control of Alveolar Macrophages: Impact on Lung Health and Disease DOI Creative Commons
Nirmal Parajuli, Kalpana Subedi, Xzaviar Kaymar Solone

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 640 - 640

Published: April 25, 2025

Alveolar macrophages (AMs) are immune cells located in the alveoli—the tiny air sacs lungs where gas exchange occurs. Their functions regulated by various epigenetic mechanisms, which essential for both healthy lung function and disease development. In lung’s microenvironment, AMs play critical roles surveillance, pathogen clearance, tissue repair. This review examines how regulation influences AM their involvement diseases. Key such as DNA methylation, histone modifications, non-coding RNAs, regulate gene expression response to environmental signals. lungs, these modifications enable quickly respond inhaled threats. However, when processes malfunction, they could contribute diseases pulmonary fibrosis, COPD, hypertension. By exploring changes affect polarization, plasticity, responses, we can gain deeper insights into role open new avenues treating preventing respiratory conditions. Ultimately, understanding mechanisms within enhances our knowledge of immunology offers potential innovative interventions restore health prevent

Language: Английский

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