The potential of targeting autophagy-related non-coding RNAs in the treatment of lung cancer

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

Lung cancer is the most prevalent malignant tumor worldwide and remains leading cause of cancer-related mortality. Despite advances in treatment development, lung patients often face poor quality life low survival rates. Increasing evidence highlights significant roles autophagy non-coding RNAs (ncRNAs) initiation, progression, therapeutic response cancer. Autophagy ncRNAs can function as both tumor-promoting tumor-suppressing factors Therefore, investigating provides valuable insights into its pathophysiology. At same time, RNA also plays an important role regulating autophagy. This study reveals that affects occurrence development through multiple pathways. Then, we studied cancer, (e.g., lncRNAs, miRNAs, circRNAs piRNAs) regulate to promote or inhibit tumorigenesis, metastasis drug resistance Finally, problems solutions were explored. These findings suggest be potential targets for

Language: Английский

Circular RNAs in glioma progression: Fundamental mechanisms and therapeutic potential: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 313, P. 144360 - 144360

Published: May 17, 2025

Language: Английский