Tumor-Associated Macrophages: Polarization, Immunoregulation, and Immunotherapy DOI Creative Commons
Abdullah F. U. H. Saeed

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 741 - 741

Published: May 19, 2025

Tumor-associated macrophages’ (TAMs) origin, polarization, and dynamic interaction in the tumor microenvironment (TME) influence cancer development. They are essential for homeostasis, monitoring, immune protection. Cells from bone marrow or embryonic progenitors dynamically polarize into pro- anti-tumor M2 M1 phenotypes based on cytokines metabolic signals. Recent advances TAM heterogeneity, characterization, immunological responses, therapy described here. The manuscript details functions their role resistance to PD-1/PD-L1 blockade. Similarly, TAM-targeted approaches, such as CSF-1R inhibition PI3Kγ-driven reprogramming, discussed address immunity suppression. Furthermore, innovative biomarkers combination may enhance TAM-centric therapies. It also stresses relevance of this distinct cell human health disease, which could impact future research

Language: Английский

Mesenchymal stem cell exosomes therapy for the treatment of traumatic brain injury: mechanism, progress, challenges and prospects DOI Creative Commons
Ming-wei Liu, Hua Li,

Gang Xiong

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 11, 2025

Language: Английский

Citations

1
Metabolic Reprogramming in Cholangiocarcinoma Cancer Stem Cells: Emerging Therapeutic Paradigms DOI
Qi Wang, Timothy E. Long, Peili Tang

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217714 - 217714

Published: April 1, 2025

Language: Английский

Citations

0
The Metabolic Landscape of Cancer Stem Cells: Insights and Implications for Therapy DOI Creative Commons

Martina Milella,

Monica Rutigliano,

Savio Domenico Pandolfo

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 717 - 717

Published: May 15, 2025

Cancer stem cells (CSCs) are a subpopulation with self-renewal and differentiation capacities believed to be responsible for tumor initiation, progression, recurrence. These exhibit unique metabolic features that contribute their stemness survival in hostile microenvironments. Like non-stem cancer cells, CSCs primarily rely on glycolysis ATP production, akin the Warburg effect. However, also show increased dependence alternative pathways, such as oxidative phosphorylation (OXPHOS) fatty acid metabolism, which provide necessary energy building blocks therapy resistance. The plasticity of enables them adapt fluctuating nutrient availability hypoxic conditions within tumor. Recent studies highlight importance these shifts maintaining CSC phenotype promoting progression. model suggests small, metabolically adaptable drives growth can switch between mitochondrial enhancing under stress dormant states. Targeting metabolism offers promising therapeutic strategy; however, adaptability complicates eradication. A multi-targeted approach addressing various pathways is essential effective elimination, underscoring need further research into specific markers mechanisms distinguish from normal successful intervention.

Language: Английский

Citations

0
Tumor-Associated Macrophages: Polarization, Immunoregulation, and Immunotherapy DOI Creative Commons
Abdullah F. U. H. Saeed

Cells, Journal Year: 2025, Volume and Issue: 14(10), P. 741 - 741

Published: May 19, 2025

Tumor-associated macrophages’ (TAMs) origin, polarization, and dynamic interaction in the tumor microenvironment (TME) influence cancer development. They are essential for homeostasis, monitoring, immune protection. Cells from bone marrow or embryonic progenitors dynamically polarize into pro- anti-tumor M2 M1 phenotypes based on cytokines metabolic signals. Recent advances TAM heterogeneity, characterization, immunological responses, therapy described here. The manuscript details functions their role resistance to PD-1/PD-L1 blockade. Similarly, TAM-targeted approaches, such as CSF-1R inhibition PI3Kγ-driven reprogramming, discussed address immunity suppression. Furthermore, innovative biomarkers combination may enhance TAM-centric therapies. It also stresses relevance of this distinct cell human health disease, which could impact future research

Language: Английский

Citations

0