Emerging roles of exosomal circRNAs in non-small cell lung cancer

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 30, 2025

Despite the prevalence of non-small cell lung cancer (NSCLC) is high, limited early detection and management these tumors are restricted since there an absence reliable precise diagnostic biomarkers therapeutic targets. Exosomes transport functional molecules for facilitating intercellular communication, especially in tumor microenvironment, indicating their potential as Circular RNA (circRNA), a type non-coding possessing covalently closed loop structure, substantial abundance, tissue-specific expression patterns, stably enriched exosomes. In recent years, significant breakthroughs have been made research on exosomal circRNA NSCLC. This review briefly introduces biogenesis, characterizations, functions circRNAs exosomes, systematically describes biological mechanisms addition, this study summarizes role progression NSCLC discusses clinical significance targets

Language: Английский

Circular RNAs modulate cell death in cardiovascular diseases

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 2, 2025

Language: Английский