The Spine Journal, Journal Year: 2024, Volume and Issue: 24(7), P. 1153 - 1161
Published: March 4, 2024
Language: Английский
Bone, Journal Year: 2025, Volume and Issue: 193, P. 117423 - 117423
Published: Feb. 9, 2025
Language: Английский
Citations
2
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: May 31, 2023
As a chronic progressive autoimmune disease, rheumatoid arthritis (RA) is characterized by mainly damaging the synovium of peripheral joints and causing joint destruction early disability. RA also associated with high incidence rate mortality cardiovascular disease. Recently, relationship between lipid metabolism has gradually attracted attention. Plasma changes in patients are often detected clinical tests, systemic inflammatory status drug treatment can interact metabolic level body. With development metabolomics, small molecules potential pathways have been discovered, which makes or after more comprehensive. This article reviews patients, as well inflammation, destruction, level. In addition, this review describes effect anti-rheumatic drugs dietary intervention on profile to better understand RA.
Language: Английский
Citations
41
npj Metabolic Health and Disease, Journal Year: 2024, Volume and Issue: 2(1)
Published: July 1, 2024
Abstract Bone is constantly being remodeled, and this process orchestrated by a dynamic crosstalk of bone cells, including osteoclasts, osteoblasts, osteocytes. Recent evidence suggests that cellular metabolism plays crucial role in the differentiation function cells facilitates adaptation to changes microenvironment. Moreover, affects whole-body energy metabolism. However, it not yet completely understood how different coordinate metabolic processes under physiological conditions, altered contribute pathological conditions where balance among disrupted. Therefore, gaining better understanding distinct requirements can provide insights into dysfunction be used identify new therapeutic approaches treat diseases. Here, we discuss recent advances reprogramming cells.
Language: Английский
Citations
9
International Journal of Oral Science, Journal Year: 2023, Volume and Issue: 15(1)
Published: Dec. 1, 2023
Abstract Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated cellular metabolic homeostasis plays a central role in mediating fate, tissue regeneration, homeostasis. Thus, thorough understanding of the mechanisms regulate cells may contribute to our knowledge on how is provide novel insights for disease management. this review, we summarize known relationship between regulation molecular pathways cells. We also discuss potential targets therapy describe current limitations future directions development these therapeutic targets.
Language: Английский
Citations
18
Journal of Agricultural Production, Journal Year: 2024, Volume and Issue: 5(1), P. 55 - 72
Published: March 31, 2024
"Nano", which derives from the Latin word nanus and means dwarf, refers to a very small unit of measurement equal one billionth meter. Nanotechnology, deals with manipulation matter at atomic molecular level, has an application area in animal husbandry as well many fields. Nano-sized feed additives, have come forefront livestock sector recent years, become innovative used increase nutritional value feeds optimize health performance. Since these additives are nano-sized particles increased specific surface area, they can positive effect on number factors such digestibility, nutrient absorption, immune system, growth development. Minerals form nanoparticles bioavailability by passing through intestinal wall body cells faster compared larger particles. The nano level substance not only increases productivity animals, but also brings potential improve functionality molecules. Nano digestion absorption feed, allowing animals benefit more effectively. However, there several challenges associated this approach. These include for endotoxin production, reduced due interaction natural nutrients, possibility nanoparticle accumulation body, risks, ethical considerations, environmental concerns some negative effects interference nutrients that be avoided encapsulation. This article discusses studies offer benefits nutrition.
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2902 - 2902
Published: March 1, 2024
Hemoglobinopathies are monogenic disorders affecting hemoglobin synthesis. Thalassemia and sickle cell disease (SCD) considered the two major hemoglobinopathies. is a genetic disorder one of hemoglobinopathies determined by an impairment globin chain production, which causes alteration erythropoiesis, improvement in hemolysis, iron homoeostasis. In SCD, mutations on β-globin results substitution glutamic acid valine with consequent formation Hemoglobin S (HbS). Several factors involved bone metabolism patients hemoglobinopathies, among them hormonal deficiency, marrow hyperplasia, overload, inflammation, increased turnover. Bone result balance maintenance between deposition resorption, osteoblasts (OBs) osteoclasts (OCs). An this responsible for onset diseases, such as osteoporosis (OP). Therefore, here we will discuss possible therapeutic strategies to contain and/or counteract health these patients, taking into consideration not only pharmacological treatments already used clinical armamentarium, but also new strategies.
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 12017 - 12017
Published: Oct. 10, 2022
The relationship between lipid metabolism and bone mineral density (BMD) is still not fully elucidated. Despite the presence of investigations using osteoporotic animal models, clinical studies in humans are limited. In this work, untargeted lipidomics profiling liquid chromatography-mass spectrometry (LC-MS) analysis human serum samples was performed to identify profile associated with low (LBMD), a subsequent examination potential biomarkers related OP risk prediction or progression. A total 69 participants were recruited for cohort study, including group (OP, n = 25), osteopenia (ON, 22), control (Ctrl, 22). LBMD included ON patients. effect confounding factors such as age, gender, profile, body mass index (BMD), chronic diseases, medications excluded from dataset. results showed clear separation clustering Ctrl (Q2 0.944, R2 0.991), indicating significant difference lipids profile. addition, 322 putatively identified molecules dysregulated, 163 up- 159 down-regulated LBMD, compared Ctrl. most significantly dysregulated subclasses phosphatidylcholines (PC) (n 81, 25.16% all 322), followed by triacylglycerol (TG) 65, 20.19%), then phosphatidylethanolamine (PE) 40, 12.42%). groups glycerophospholipids, LPC (7.45%), LPE (5.59%), PI (2.48%) also LBMD. These findings provide insights into alteration involved remodeling may drive development therapeutic targets nutritional strategies management.
Language: Английский
Citations
25
Metabolites, Journal Year: 2023, Volume and Issue: 13(4), P. 578 - 578
Published: April 21, 2023
Bone is a dynamic tissue composed of cells, an extracellular matrix, and mineralized portion. Osteoblasts are responsible for proper bone formation remodeling, function. These processes endergonic require cellular energy in the form adenosine triphosphate (ATP), which derived from various sources such as glucose, fatty acids, amino acids. However, other lipids cholesterol have also been found to play critical role homeostasis can contribute overall bioenergetic capacity osteoblasts. In addition, several epidemiological studies link between elevated cholesterol, cardiovascular disease, enhanced risk osteoporosis, increased metastasis cancer patients. This review focuses on how its derivatives, cholesterol-lowering medications (statins) regulate osteoblast function formation. It highlights molecular mechanisms underlying cholesterol–osteoblast crosstalk.
Language: Английский
Citations
11
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Aug. 20, 2024
We conducted this cross-sectional study to investigate the independent associations between lipid metabolites and osteoporotic fractures among participants aged 40–69 years from UK Biobank. Serum lipid, lipoprotein levels nuclear magnetic resonance (NMR) based metabolic biomarkers were measured at baseline. multivariable logistic analyses potential concentrations of in both men women. The odds ratios (ORs) for calculated on their lowest tertile. Over a median follow-up period 15 years, total 978 4515 women diagnosed with osteoporosis, whereas 138 327 encountered incident fractures. Statistically significant disparities identified NMR-based compared those without. Out 144 distinct known, 35 exhibited patients osteoporosis. Following adjustment confounding factors, degree unsaturation (p = 0.0066) docosahexaenoic acids 0.0011) male increased risk And high level different HDL 0.0153), 3-Hydroxybutyrate 0.0012) Sphingomyelins 0.0036) decreased female patients. This outcome indicates that these may potentially have unique roles independently contributing occurrence
Language: Английский
Citations
4
Poultry Science, Journal Year: 2025, Volume and Issue: 104(3), P. 104849 - 104849
Published: Jan. 23, 2025
Language: Английский
Citations
0