Current Research in Food Science,
Journal Year:
2024,
Volume and Issue:
8, P. 100687 - 100687
Published: Jan. 1, 2024
The
potential
adverse
effects
of
the
plant-based
dietary
pattern
on
bone
health
have
received
widespread
attention.
However,
biological
mechanisms
underlying
diets
remain
incompletely
understood.
objective
this
study
was
to
identify
biomarkers
between
and
loss
utilizing
metabolomic
techniques
in
Taizhou
Imaging
Study
(TIS)
(N
=
788).
Plant-based
diet
indexes
(overall
index
(PDI),
healthy
(hPDI),
unhealthy
(uPDI))
were
calculated
using
food
frequency
questionnaire,
mineral
density
(BMD)
measured
dual-energy
X-ray
absorptiometry.
A
multinomial
logistic
regression
used
explore
associations
with
loss.
Furthermore,
mediation
analysis
exploratory
factor
(EFA)
performed
mediated
metabolites
association
BMD
T-score.
Our
results
showed
that
higher
hPDI
uPDI
positively
associated
Moreover,
nineteen
significantly
T-score,
among
them,
seven
uPDI.
Except
for
cholesterol
esters
VLDL-1,
remaining
six
negative
Interestingly,
we
observed
same
positive
fresh
fruit
Collectively,
our
support
deleterious
discover
effect
findings
offer
valuable
insights
could
optimize
recommendations
interventions,
contributing
alleviate
diets.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: May 31, 2023
As
a
chronic
progressive
autoimmune
disease,
rheumatoid
arthritis
(RA)
is
characterized
by
mainly
damaging
the
synovium
of
peripheral
joints
and
causing
joint
destruction
early
disability.
RA
also
associated
with
high
incidence
rate
mortality
cardiovascular
disease.
Recently,
relationship
between
lipid
metabolism
has
gradually
attracted
attention.
Plasma
changes
in
patients
are
often
detected
clinical
tests,
systemic
inflammatory
status
drug
treatment
can
interact
metabolic
level
body.
With
development
metabolomics,
small
molecules
potential
pathways
have
been
discovered,
which
makes
or
after
more
comprehensive.
This
article
reviews
patients,
as
well
inflammation,
destruction,
level.
In
addition,
this
review
describes
effect
anti-rheumatic
drugs
dietary
intervention
on
profile
to
better
understand
RA.
npj Metabolic Health and Disease,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: July 1, 2024
Abstract
Bone
is
constantly
being
remodeled,
and
this
process
orchestrated
by
a
dynamic
crosstalk
of
bone
cells,
including
osteoclasts,
osteoblasts,
osteocytes.
Recent
evidence
suggests
that
cellular
metabolism
plays
crucial
role
in
the
differentiation
function
cells
facilitates
adaptation
to
changes
microenvironment.
Moreover,
affects
whole-body
energy
metabolism.
However,
it
not
yet
completely
understood
how
different
coordinate
metabolic
processes
under
physiological
conditions,
altered
contribute
pathological
conditions
where
balance
among
disrupted.
Therefore,
gaining
better
understanding
distinct
requirements
can
provide
insights
into
dysfunction
be
used
identify
new
therapeutic
approaches
treat
diseases.
Here,
we
discuss
recent
advances
reprogramming
cells.
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
Bisphosphonates,
a
class
of
anti-osteoporotic
drugs,
are
known
to
inhibit
bone
resorption
and
reduce
fracture
risk.
This
review
evaluates
the
evidence
for
their
use
also
aims
assess
potential
benefits,
safety,
effectiveness
in
reducing
risk
myocardial
infarction.
addition
conventional
role
health,
accumulation
calcium
within
vascular
walls.
Therefore,
they
decrease
infarction
patients
with
higher
likelihood
cardiovascular
problems.
However,
may
exacerbate
other
cardiac
issues
do
not
appear
mortality
rates.
when
used
as
an
drug,
generally
have
favorable
safety
profile
osteoporosis,
regardless
treatment
duration,
age,
sex,
or
underlying
conditions.
Nonetheless,
strict
adherence
bisphosphonate
therapy
over
longer
duration
help
International Journal of Oral Science,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: Dec. 1, 2023
Abstract
Many
tissues
and
organ
systems
have
intrinsic
regeneration
capabilities
that
are
largely
driven
maintained
by
tissue-resident
stem
cell
populations.
In
recent
years,
growing
evidence
has
demonstrated
cellular
metabolic
homeostasis
plays
a
central
role
in
mediating
fate,
tissue
regeneration,
homeostasis.
Thus,
thorough
understanding
of
the
mechanisms
regulate
cells
may
contribute
to
our
knowledge
on
how
is
provide
novel
insights
for
disease
management.
this
review,
we
summarize
known
relationship
between
regulation
molecular
pathways
cells.
We
also
discuss
potential
targets
therapy
describe
current
limitations
future
directions
development
these
therapeutic
targets.
Journal of Agricultural Production,
Journal Year:
2024,
Volume and Issue:
5(1), P. 55 - 72
Published: March 31, 2024
"Nano",
which
derives
from
the
Latin
word
nanus
and
means
dwarf,
refers
to
a
very
small
unit
of
measurement
equal
one
billionth
meter.
Nanotechnology,
deals
with
manipulation
matter
at
atomic
molecular
level,
has
an
application
area
in
animal
husbandry
as
well
many
fields.
Nano-sized
feed
additives,
have
come
forefront
livestock
sector
recent
years,
become
innovative
used
increase
nutritional
value
feeds
optimize
health
performance.
Since
these
additives
are
nano-sized
particles
increased
specific
surface
area,
they
can
positive
effect
on
number
factors
such
digestibility,
nutrient
absorption,
immune
system,
growth
development.
Minerals
form
nanoparticles
bioavailability
by
passing
through
intestinal
wall
body
cells
faster
compared
larger
particles.
The
nano
level
substance
not
only
increases
productivity
animals,
but
also
brings
potential
improve
functionality
molecules.
Nano
digestion
absorption
feed,
allowing
animals
benefit
more
effectively.
However,
there
several
challenges
associated
this
approach.
These
include
for
endotoxin
production,
reduced
due
interaction
natural
nutrients,
possibility
nanoparticle
accumulation
body,
risks,
ethical
considerations,
environmental
concerns
some
negative
effects
interference
nutrients
that
be
avoided
encapsulation.
This
article
discusses
studies
offer
benefits
nutrition.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2902 - 2902
Published: March 1, 2024
Hemoglobinopathies
are
monogenic
disorders
affecting
hemoglobin
synthesis.
Thalassemia
and
sickle
cell
disease
(SCD)
considered
the
two
major
hemoglobinopathies.
is
a
genetic
disorder
one
of
hemoglobinopathies
determined
by
an
impairment
globin
chain
production,
which
causes
alteration
erythropoiesis,
improvement
in
hemolysis,
iron
homoeostasis.
In
SCD,
mutations
on
β-globin
results
substitution
glutamic
acid
valine
with
consequent
formation
Hemoglobin
S
(HbS).
Several
factors
involved
bone
metabolism
patients
hemoglobinopathies,
among
them
hormonal
deficiency,
marrow
hyperplasia,
overload,
inflammation,
increased
turnover.
Bone
result
balance
maintenance
between
deposition
resorption,
osteoblasts
(OBs)
osteoclasts
(OCs).
An
this
responsible
for
onset
diseases,
such
as
osteoporosis
(OP).
Therefore,
here
we
will
discuss
possible
therapeutic
strategies
to
contain
and/or
counteract
health
these
patients,
taking
into
consideration
not
only
pharmacological
treatments
already
used
clinical
armamentarium,
but
also
new
strategies.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(19), P. 12017 - 12017
Published: Oct. 10, 2022
The
relationship
between
lipid
metabolism
and
bone
mineral
density
(BMD)
is
still
not
fully
elucidated.
Despite
the
presence
of
investigations
using
osteoporotic
animal
models,
clinical
studies
in
humans
are
limited.
In
this
work,
untargeted
lipidomics
profiling
liquid
chromatography-mass
spectrometry
(LC-MS)
analysis
human
serum
samples
was
performed
to
identify
profile
associated
with
low
(LBMD),
a
subsequent
examination
potential
biomarkers
related
OP
risk
prediction
or
progression.
A
total
69
participants
were
recruited
for
cohort
study,
including
group
(OP,
n
=
25),
osteopenia
(ON,
22),
control
(Ctrl,
22).
LBMD
included
ON
patients.
effect
confounding
factors
such
as
age,
gender,
profile,
body
mass
index
(BMD),
chronic
diseases,
medications
excluded
from
dataset.
results
showed
clear
separation
clustering
Ctrl
(Q2
0.944,
R2
0.991),
indicating
significant
difference
lipids
profile.
addition,
322
putatively
identified
molecules
dysregulated,
163
up-
159
down-regulated
LBMD,
compared
Ctrl.
most
significantly
dysregulated
subclasses
phosphatidylcholines
(PC)
(n
81,
25.16%
all
322),
followed
by
triacylglycerol
(TG)
65,
20.19%),
then
phosphatidylethanolamine
(PE)
40,
12.42%).
groups
glycerophospholipids,
LPC
(7.45%),
LPE
(5.59%),
PI
(2.48%)
also
LBMD.
These
findings
provide
insights
into
alteration
involved
remodeling
may
drive
development
therapeutic
targets
nutritional
strategies
management.
Metabolites,
Journal Year:
2023,
Volume and Issue:
13(4), P. 578 - 578
Published: April 21, 2023
Bone
is
a
dynamic
tissue
composed
of
cells,
an
extracellular
matrix,
and
mineralized
portion.
Osteoblasts
are
responsible
for
proper
bone
formation
remodeling,
function.
These
processes
endergonic
require
cellular
energy
in
the
form
adenosine
triphosphate
(ATP),
which
derived
from
various
sources
such
as
glucose,
fatty
acids,
amino
acids.
However,
other
lipids
cholesterol
have
also
been
found
to
play
critical
role
homeostasis
can
contribute
overall
bioenergetic
capacity
osteoblasts.
In
addition,
several
epidemiological
studies
link
between
elevated
cholesterol,
cardiovascular
disease,
enhanced
risk
osteoporosis,
increased
metastasis
cancer
patients.
This
review
focuses
on
how
its
derivatives,
cholesterol-lowering
medications
(statins)
regulate
osteoblast
function
formation.
It
highlights
molecular
mechanisms
underlying
cholesterol–osteoblast
crosstalk.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 20, 2024
We
conducted
this
cross-sectional
study
to
investigate
the
independent
associations
between
lipid
metabolites
and
osteoporotic
fractures
among
participants
aged
40–69
years
from
UK
Biobank.
Serum
lipid,
lipoprotein
levels
nuclear
magnetic
resonance
(NMR)
based
metabolic
biomarkers
were
measured
at
baseline.
multivariable
logistic
analyses
potential
concentrations
of
in
both
men
women.
The
odds
ratios
(ORs)
for
calculated
on
their
lowest
tertile.
Over
a
median
follow-up
period
15
years,
total
978
4515
women
diagnosed
with
osteoporosis,
whereas
138
327
encountered
incident
fractures.
Statistically
significant
disparities
identified
NMR-based
compared
those
without.
Out
144
distinct
known,
35
exhibited
patients
osteoporosis.
Following
adjustment
confounding
factors,
degree
unsaturation
(p
=
0.0066)
docosahexaenoic
acids
0.0011)
male
increased
risk
And
high
level
different
HDL
0.0153),
3-Hydroxybutyrate
0.0012)
Sphingomyelins
0.0036)
decreased
female
patients.
This
outcome
indicates
that
these
may
potentially
have
unique
roles
independently
contributing
occurrence
