Association between lipid accumulation products and osteoarthritis among adults in the United States: A cross-sectional study, NHANES 2017-2020

Preventive Medicine, Journal Year: 2024, Volume and Issue: 180, P. 107861 - 107861

Published: Jan. 19, 2024

Language: Английский

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Lipid-based insulin-resistance markers predict cardiovascular events in metabolic dysfunction associated steatotic liver disease

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 20, 2024

Insulin resistance (IR) is the cornerstone of Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), pathophysiologically being key link between MASLD, metabolic disorders, and cardiovascular (CV) diseases. There are no prospective studies comparing predictive values different markers insulin in identifying presence MASLD associated risk events (CVEs).

Language: Английский

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Whether weekend warriors (WWs) achieve equivalent benefits in lipid accumulation products (LAP) reduction as other leisure-time physical activity patterns? -Results from a population-based analysis of NHANES 2007–2018

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 9, 2024

Abstract Background Obesity is characterized by excessive fat accumulation in the body. Physical activity (PA) an effective intervention to combat obesity, but effectiveness of different PA patterns on controlling obesity unclear. Lipid product (LAP), derived from waist circumference and triglycerides, a novel indicator for evaluation. However, association between (i.e., weekend warriors regularly active) LAP remains unexplored. This study aims elucidate relationship US adult population. Methods Adult individuals with complete data LAP, patterns, other covariates National Health Nutrition Examination Survey (NHANES) database (2007–2018) were included this study. Multivariate linear regression models utilized explore LAP. Subgroup analyses, interaction tests, restricted cubic spline (RCS) threshold saturation effect analyses also performed investigate stability nonlinearity PA-LAP association, respectively. Results A total 11,212 participants After adjusting all potential covariates, being active (RA) (β=-8.85, P < 0.05) obtained significantly higher reduction as opposed (WWs) (β=-4.70, = 0.3841). Furthermore, subgroup tests indicated that was more pronounced education levels (P 0.0084) diabetes 0.0062). Additionally, significant, non-linear, negative correlation weekly non-inactive identified RCS analysis overall 0.001, 0.009). 440 min found arouse favorable reduction. Conclusions Being better WWs. For adults, engaging than per week helps reduce effectively.

Language: Английский

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Associations between body fat anthropometric indices and mortality among individuals with metabolic syndrome

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 27, 2024

Language: Английский

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Perspective from NHANES data: synergistic effects of visceral adiposity index and lipid accumulation products on diabetes risk

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Language: Английский

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Lipid accumulation product index is a risk factor for osteoporosis in elderly patients with type 2 diabetes mellitus

International Journal of Diabetes in Developing Countries, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

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Diagnostic performance of sixteen biomarkers for MASLD: A study in a Mexican cohort

Clinics and Research in Hepatology and Gastroenterology, Journal Year: 2024, Volume and Issue: 48(7), P. 102400 - 102400

Published: June 18, 2024

Language: Английский

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Lipid Accumulation Product is a Valid Predictor of Hepatic Steatosis and Nonalcoholic Fatty Liver Disease

Biomarkers in Medicine, Journal Year: 2024, Volume and Issue: 18(3), P. 123 - 135

Published: Feb. 1, 2024

Aims: To evaluate and compare lipid accumulation product (LAP) with alanine aminotransferase (ALT), aspartate (AST), visceral adiposity index (VAI) triglyceride-glucose (TyG) as biomarkers for hepatic steatosis nonalcoholic fatty liver disease (NAFLD). Methods: LAP, ALT, AST, VAI TyG were measured in 52 biopsy-proven NAFLD patients 21 control subjects. Additionally, LAP was also 448 ultrasound-proven 1009 Results: positively associated inflammation NAFLD. The risk of related to TyG, but showed a better area under the receiver operating characteristic curve performed well recognizing Conclusion: is an ideal biomarker

Language: Английский

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Adipocentric origin of the common cardiometabolic complications of obesity in the young up to the very old: pathophysiology and new therapeutic opportunities

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: April 8, 2024

Obesity is a multifactorial chronic disease characterized by an excess of adipose tissue, affecting people all ages. In the last 40 years, incidence overweight and obesity almost tripled worldwide. The accumulation “visceral” tissue increases with aging, leading to several cardio-metabolic consequences: from increased blood pressure overt arterial hypertension, insulin-resistance type 2 diabetes mellitus (T2DM), dyslipidemia, kidney (CKD), obstructive sleep apnea. increasing use innovative drugs, namely glucagon-like peptide-1 receptor agonists (GLP1-RA) sodium-glucose cotransporter-2 inhibitors (SGLT2-i), changing management its related cardiovascular complications significantly. These first considered only for T2DM treatment, are now used in patients visceral adiposity or obese patients, as no longer just risk factor but critical condition at basis common metabolic, cardiovascular, renal diseases. An adipocentric vision approach should become cornerstone integrated reducing avoiding onset obesity-related multiple factors their clinical complications. According recent progress basic research on adiposity, this narrative review aims contribute novel focusing pathophysiological therapeutic insights.

Language: Английский

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Cardiometabolic Index (CMI), Lipid Accumulation Products (LAP), Waist Triglyceride Index (WTI) and the risk of acute pancreatitis: a prospective study in adults of North China

Lipids in Health and Disease, Journal Year: 2023, Volume and Issue: 22(1)

Published: Nov. 9, 2023

To investigate the correlation between anthropometric indexes [cardiometabolic index (CMI), lipid accumulation products (LAP), waist triglyceride (WTI), and body mass (BMI)] acute pancreatitis (AP) in a Chinese adult population.The present investigation consisted of prospective group including 117,326 subjects who were enrolled Kailuan investigation. The individuals categorized into quartiles based on their baseline levels CMI, LAP, WIT. BMI was three distinctive groups: normal weight (BMI < 24 kg/m2), overweight 24-28 kg /m2), obesity ≥ 28 kg/m2). data subjected to analysis order these incidence AP. Cox regression models employed assess relative risk AP while accounting for known factors through appropriate adjustments.Over course median follow-up duration 12.59 ± 0.98 years, we documented 401 incident cases. Incidence density cumulative rates increased with increase WTI. After multivariate adjustment, fourth quartile WTI exhibited greatest [CMI: hazard ratio (HR) 1.93, 95% confidential interval (CI) (1.45-2.57); LAP: HR 2.00, CI(1.49-2.68); WTI: 2.13,95% CI (1.59-2.83)]. In comparison group, kg/m2) had an elevated (HR = 1.58, CI: 1.21-2.05). Furthermore, incremental effect combined CMI prognostic value greater than that alone (the C statistics demonstrated result 0.607 versus 0.546; integrated discrimination improvement revealed 0.321%; net reclassification 1.975%).We found positively independently connected Additionally, demonstrates superior capacity other anticipating

Language: Английский

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