Statin Monotherapy Not Inferior to Aspirin or Combined Aspirin and Statins Reducing the Incidences of Cirrhosis, HCC, and Mortality in MAFLD/MASH Patients: A Population Cohort Study

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 6495 - 6511

Published: Dec. 1, 2024

Metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic steatohepatitis (MASH) pose significant risks for cirrhosis hepatocellular carcinoma (HCC). Daily aspirin statins could reduce HCC in patients with MAFLD/MASH. We aimed to clarify whether combined exert a synergistic effect on prevention of Patients their clinical data were collected from the National Health Insurance Research Database (NHIRD), encompassing about 20 million population. A total 735,574 MAFLD/MASH between January 1, 2009, December 31, 2020 identified. After applying exclusion criteria, 662,004 cases enrolled, follow-up period 3 years. Propensity score matching was employed comparative analysis. Our findings indicate that statin use significantly reduced incidence (p < 0.001) compared or alone, non-use both drugs. However, therapy did not confer additional benefits reducing mortality rates HCC. Furthermore, monotherapy exhibited more pronounced alone therapy. study underscores inferior aspirin-statin therapies terms chemoprevention cirrhosis, HCC, overall patients.

Language: Английский

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Water decoction of Pericarpium citri reticulatae and Amomi fructus ameliorates alcohol-induced liver disease involved in the modulation of gut microbiota and TLR4/NF-κB pathway

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 20, 2024

Introduction Alcohol consumption alters the diversity and metabolic activities of gut microbiota, leading to intestinal barrier dysfunction contributing development alcoholic liver disease (ALD), which is most prevalent cause advanced diseases. In this study, we investigated protective effects action mechanism an aqueous extraction Pericarpium citri reticulatae Amomi fructus (PFE) on injury. Methods C57BL/6 mice were used establish mouse model injury orally administered 500 1,000 mg/kg/d PFE for 2 weeks. Histopathology, immunohistochemistry, immunofluorescence, Western blotting, qRT-PCR, 16S rDNA amplicon sequencing analyze in treatment alcohol-induced Results Treatment with significantly improved injury, as illustrated by normalization serum alanine aminotransferase, aspartate total triglyceride, cholesterol levels ALD a dose-dependent manner. Administration not only maintained integrity prominently upregulating mucous production tight junction protein expressions but also sensibly reversed dysregulation microecology alcohol-treated mice. Furthermore, reduced hepatic lipopolysaccharide (LPS) attenuated oxidative stress well inflammation related TLR4/NF-κB signaling pathway. The supplementation promoted short-chain fatty acids (SCFAs) Conclusion effectively prevents may regulate LPS-involved gut–liver axis; could provide valuable insights drugs prevent treat ALD.

Language: Английский

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Serum immunoglobulin A levels: Diagnostic utility in alcoholic liver disease and association with liver fibrosis in steatotic liver disease

Biomedical Reports, Journal Year: 2024, Volume and Issue: 21(4)

Published: Aug. 1, 2024

The relationship between immunoglobulin A (IgA) levels and chronic liver disease remains poorly understood. present study evaluated the clinical significance of IgA in 478 new patients who visited Outpatient Clinic Nagasaki Harbor Medical Center (Nagasaki, Japan). Serum comparison to stiffness (LS), as measured using a FibroScan® device, were 358 patients. Furthermore, 270 patients, associations serum body composition analyzed computed tomography. groups with Child‑Pugh classification B C (CPGBC), alcoholic (ALD), steatotic (SLD) or diabetes higher than CPGA, non‑ALD, non‑SLD no diabetes, respectively. Logistic regression analysis showed that CPGBC, ALD, high IgG (>1,700 mg/dl), macrophage galactose‑specific lectin‑2 binding protein glycosylation isomer (M2BPGi) (>1 cut‑off index) contributing factors for level (>410 mg/dl). ratio divided by was highest followed those metabolic dysfunction‑associated SLD (MASLD) non‑SLD. In SLD, associated more LS M2BPGi fibrosis‑4 (FIB‑4) multiple analysis. receiver operating characteristic analysis, level, M2BPG, FIB‑4 had similar area under curve values discriminating (>8 kPa) from low (≤8 SLD. also visceral fat, this association only found women. conclusion, elevated is an indicator fibrosis reflects presence increased fat level. Therefore, considered useful marker severity current era

Language: Английский

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Therapeutic Potential of Foodborne Indole Derived from Chinese Stinky Tofu in Reducing Intestinal Inflammation and Enhancing Barrier Function to Mitigate Alcoholic Liver Injury

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Indole, a compound in Chinese stinky tofu (ST), acts as ligand for the aryl hydrocarbon receptor (AHR). Despite extensive research on prebiotic compounds, indole's specific role ST remains unexplored. This study used an ethanol gavage method to create ALD (alcoholic liver disease) mouse model and investigate dietary effects intestinal barrier. Our findings indicate that after 6 weeks of being fed ST, indole present (2 mg/day) robustly activated AHR, upregulating its target gene, CYP1A1 (cytochrome P450 1A1 enzyme). activation significantly reduced permeability, mitigated alcohol-induced oxidative stress inflammation, restored barrier function. Consequently, demonstrates foodborne substantially reduces alcohol absorption lowers expression levels inflammation-related factors, thereby slowing progression ALD. These results highlight therapeutic potential treating developing functional foods.

Language: Английский

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Could chronic opioid use be an additional risk of hepatic damage in patients with previous liver diseases, and what is the role of microbiome?

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Among illicit drugs, addiction from opioids and synthetic is soaring in an unparalleled manner with its unacceptable amount of deaths. Apart these extreme consequences, the liver toxicity another important aspect that should be highlighted. Accordingly, chronic use substances, which fentanyl most frequently consumed, represents additional risk damage patients underlying disease. These observations are drawn various preclinical clinical studies present literature. Several downstream molecular events have been proposed, but recent pieces research strengthen hypothesis dysbiosis gut microbiota a solid mechanism inducing worsening by both alcohol drugs. In this scenario, flora modification ascribed to non-alcoholic fatty disease performs additive role. Interestingly enough, HBV HCV infections impact gut-liver axis. end, authors tried solicit attention operators on major healthcare problem.

Language: Английский

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