Remnant cholesterol and its variability independent of low density lipoprotein cholesterol predict metabolic dysfunction associated steatotic liver disease

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 6, 2025

This study aimed to determine whether remnant cholesterol (RC) and its variability can predict the onset of metabolic dysfunction-associated steatotic liver disease (MASLD) independently low-density lipoprotein (LDL-C) levels. A longitudinal cohort involving 43,065 participants who underwent at least two physical examinations was conducted. used Cox proportional hazards models assess relationships among RC quartile levels (Q1–Q4), visit-to-visit variability, risk MASLD. quantified using several metrics: standard deviation (SD), logSD, average real (ARV), logARV, mean absolute (MAD), logMAD. Concurrently, this utilized a combined analysis LDL-C groups independent MASLD associated with RC. During 3.19 years (SD 2.06 years), 8374 patients (19.45%) developed Compared Q1, Q4 significantly greater (hazard ratio [HR] 1.309, 95% confidence interval [CI] 1.220–1.403, P < 0.001). The fully adjusted model revealed that HRs SD, ARV, MAD logMAD were 1.400 (95% CI 1.305–1.502), 1.278 1.188–1.374), 1.152 1.079–1.229), 1.183 1.140–1.227), 1.578 1.433–1.737) 1.263 1.175–1.358), respectively. In both subgroups (≥ 3.4 mmol/L mmol/L), high baseline elevated (HR 1.208, 1.148–1.270, 0.001; HR 1.246, 1.129–1.374, in healthy individuals, irrespective level. during periods provides predictive marker for identifying individuals heightened

Language: Английский

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Appropriate Statin Use in Patients With Newly Diagnosed Acute Ischemic Stroke or Myocardial Infarction at a Tertiary County Teaching Hospital

Annals of Pharmacotherapy, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Background: Statins are the mainstay of therapy in patients suffering an acute ischemic stroke (AIS) or myocardial infarction (MI); however, several studies have shown that prescribing is not optimal. Objective: The main objective this study was to evaluate percentage prescribed appropriate statin upon discharge after AIS MI. Methods: This a single-center retrospective cohort conducted at tertiary, county, teaching hospital aged 18 89 years who were newly diagnosed with MI, from September 2017 2022. Results: Six hundred thirty-six individuals hospitalized for MI according ICD-10 codes. Of these, 389 excluded, and 247 included analysis. Although 85% very high risk future ASCVD events, over 25% discharged on therapy. Patients had been taking high-intensity statins statin-naïve prior admission (156/194, 80.4%) significantly more likely be compared those low moderate-intensity home (27/53, 50.9%, p<0.0001, OR = 3.41, 95% CI 1.71 6.79). Conclusion Relevance: treatment following remains suboptimal, despite most these being further events. Significantly naïve

Language: Английский

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Remnant Cholesterol and Residual Risk of Atherosclerotic Cardiovascular Disease

Reviews in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 20, 2025

Remnant cholesterol (RC) is increasingly recognized as a key target in the treatment of atherosclerotic cardiovascular disease (ASCVD), addressing much residual risk that persists despite standard therapies. However, integrating RC into clinical practice remains challenging. Key issues, such development accessible measurement methods, identification safe and effective medications, determination optimal levels, creation RC-based stratification strategies, require further investigation. This article explores complex role ASCVD development, including its definition, metabolic pathways, association with both overall primary secondary prevention. It also examines effect current lipid-lowering therapies on levels their influence outcomes. Recent research has highlighted promising advancements aimed at lowering RC, which show potential for reducing major adverse events (MACEs). Inhibitors angiopoietin-like protein 3 (ANGPTL3), apolipoprotein C-III (apoCIII), proprotein convertase subtilisin/kexin type 9 (PCSK9) have demonstrated ability to modulate reduce MACEs by targeting specific proteins involved synthesis metabolism. There pressing need larger randomized controlled trials clarify relevant patient populations. The targeted RC-lowering holds promise significantly high rates morbidity mortality associated ASCVD.

Language: Английский

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Revisiting the safety profile of tenofovir alafenamide: methodological reflections on real-world data

Hepatology International, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

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The prognostic role of remnant cholesterol in Asian menopausal women received percutaneous coronary intervention with acute coronary syndrome

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Aug. 30, 2024

Remnant cholesterol (RC) exert a significant influence on atherosclerotic cardiovascular disease development. However, the prognostic implications of RC in menopausal women received percutaneous coronary intervention (PCI) who experiencing acute syndrome (ACS) remain uncertain.

Language: Английский

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