Correlation between liver fibrosis in non-alcoholic fatty liver disease and insulin resistance indicators: a cross-sectional study from NHANES 2017–2020

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 31, 2025

Introduction Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic worldwide, with fibrosis (LF) being crucial pathological feature in the progression NAFLD. Insulin resistance (IR) believed to play an important role pathogenesis NAFLD and development LF. This study aims explore relationship between various IR indicators LF patients Methods utilized data from National Health Nutrition Examination Survey 2017-2020 cycles. Liver steatosis were assessed using ultrasound transient elastography. To assess association multiple LF, methodology included univariate multivariate logistic regression, as well restricted cubic spline (RCS) analysis. Subsequently, we used regression develop validate predictive model for evaluated model’s performance area under curve (AUC) calibration curve. Results A total 904 final Among these patients, 153 (16.92%) had Compared non-LF significantly higher body mass index (BMI), waist circumference (WC), alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyl transferase (GGT), HbA1c, fasting blood glucose (FBG) levels (all p < 0.05). Analysis showed that TyG, TyG-WHtR, TyG-BMI, TyG-WC, TyG-GGT, METS-IR, HOMA-IR After adjusting covariates, TyG-WHtR remained independent risk factor (OR=2.69; 95% CI: 2.08-3.47), indicating strong correlation The developed nomogram, incorporating AST, diabetes, AUC 0.809 (95% 0.771-0.847), good patients. Conclusions confirms significant nomogram provides practical tool early assessment. These findings underscore clinical value indices into routine practice identify high-risk enabling timely interventions prevent improve outcomes.

Language: Английский

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The association between novel metabolic parameters and all-cause/cardiovascular mortality in patients with metabolic syndrome is modified by age

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 28, 2025

Triglyceride glucose index (TyG) serves as an effective parameter for assessing metabolic status. However, it remains uncertain whether TyG and other parameters can predict clinical outcomes in people with syndrome (MetS). We investigated the association of TyG, triglyceride glucose-waist to height ratio (TyG-WHtR), score insulin resistance (METS-IR) all-cause cardiovascular mortality MetS cohort determined this changes age. Participants enrolled National Health Nutrition Examination Survey (NHANES) between 2001 2018 were selected categorized into two groups: younger individuals (age < 65 years) older ≥ years). Three new indices TyG-WHtR, METS-IR constructed. The weighted Cox proportional hazards model restricted cubic spline (RCS) models employed evaluate relation three outcomes. time-dependent receiver operating characteristic (ROC) curve assessed ability different mortality. Sensitivity analysis was conducted robustness reliability findings. study comprised a total 8271 participants, including 5456 participants 2815 1407 deaths observed over median follow-up period 8.3 years. Compared first quartile (Q1), fourth quartile's (Q4) linked increased risk (HR 1.63, 95% CI 1.12–2.39; HR 2.78, 1.68–4.61; 1.36, 1.12–2.02, respectively) 2.04, 1.15–4.90; 4.99, 1.76–14.11; 2.69, 1.89–8.15, group but not group. RCS results showed no significant non-linear associations METS-IR, (P = 0.082; P 0.712; 0.062, or 0.176; 0.793; 0.482, age TyG-WHtR demonstrated highest area under predicting 3-year group, values 0.653 0.688 Our highlight predictive value population, providing evidence medical practice public health. A study, 100 months. Weighted COX regression (left), (upper right), (cut-off 36 months) (lower right). index; WHtR ratio; Metabolic resistance; syndrome.

Language: Английский

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Targeting regulation of lipid metabolism with polysaccharide of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141660 - 141660

Published: March 1, 2025

Language: Английский

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The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism status

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Objectives The triglyceride-glucose index (TyG) is a significant parameter for evaluating metabolic health, but its link to mortality across various glucose metabolism statuses still uncertain. purpose of this study was investigate the relationship between TyG and risk all-cause cardiovascular in normoglycemia, dysglycemia, diabetic populations. Methods Participants who took part NHANES nine cycles were chosen divided into three categories: diabetes. Cox regression restricted cubic spline (RCS) models used assess linear nonlinear relations mortality, respectively. To evaluate predictive power atherogenic plasma (AIP) time-dependent ROC curve utilized. Subgroup analyses carried out separately based on age, sex, blood-pressure status. Results After median observation period 9.2 years, 2,199 deaths from all causes 606 cardiovascular-related recorded. In normoglycemic group, single standard unit rise correlated with 37% increase 42% mortality. Among diabetics, RCS revealed U-shaped relation all-cause/cardiovascular threshold value 9.1. No associations identified dysglycemia. outperformed AIP predicting 3-year groups. age-specific interaction TyG-mortality association, significance individuals <65 not ≥65 years age. Conclusion Our findings highlight TyG's role populations different metabolism, contributing new evidence public fields medical practice.

Language: Английский

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The association between modified cardiometabolic index with non-alcoholic fatty liver disease and liver fibrosis: a cross-sectional study

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 17, 2025

Language: Английский

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