Impact of urinary PAHs on psoriasis risk in U.S. adults: Insights from NHANES DOI Creative Commons

Jiang-Hui Li,

Xiaoning Yan, Jiaying Fu

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0314964 - e0314964

Published: Dec. 5, 2024

Objective Exposure to environmental pollutants is increasingly recognized as a risk factor for the development of psoriasis. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in air and might induce reactions such oxidative stress. Nevertheless, it still unclear if PAHs have any influence on prevalence psoriasis over entire population United States. The objective this study was assess association between urine Methods research included 3,673 individuals aged 20 years or older who participated 2003–2006 2009–2012 National Health Nutrition Examination Surveys (NHANES). We employed logistic regression models evaluate relationship levels PAH metabolites smoothed curve fitting illustrate concentration-response relationship. Additionally, subgroup interaction analyses were conducted elucidate these associations. Furthermore, we weighted quartile sum (WQS) regressions examine distinct effects individual mixed However, important note that NHANES sample may be subject selectivity self-reporting bias, which data’ generalisability. Results observed highest tertiles 2-NAP 2-FLU had 63% (95% CI 1.02, 2.61) 83% 1.14, 2.96) higher odds with prevalence, respectively. Meanwhile, tertile 2 3 3-PHE also significantly associated psoriasis, 65% 1.01, 2.69) 14% 1.17, 3.00), revealed significant correlation specific groups, including males, 40–60 years, BMI > 30, those hyperlipidemia. In WQS model, positive found combination (OR 1.43, 95% 1.11, 1.84), being most prevalent component across all mixtures (0.297). Conclusions Our findings indicate adults. Among metabolites, demonstrated prominent impact. Controlling exposure, an strategy minimizing exposure contaminants lowering critical raising public knowledge about health preserving health.

Language: Английский

Exploring the association between exposure to pesticides, polycyclic aromatic hydrocarbons, and phthalates and metabolic syndrome in National Health and Nutrition Examination Survey in the USA, 2007–2012: utilizing a multi-step statistical strategy DOI Creative Commons
Yadan Xu, Yifan Xu, Wen Gu

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 14, 2025

Pesticides, polycyclic aromatic hydrocarbons (PAHs), and phthalates are recognized as potential contributors to metabolic disorders. Nevertheless, the combined effect of simultaneous exposure these chemicals on syndrome (MetS) remains elusive. To explore impacts pesticides, PAHs identify critical MetS. Based National Health Nutrition Examination Survey (NHANES) database from 2007—2012, our study included 4030 non-pregnant individuals aged 20 years or older. We used weighted linear regression model, variable selection models (including LASSO BMA models), well a mixture model (WQS model) investigate correlation between Additionally, stratified analyses were performed based gender age. The generalized revealed positive 2-hydroxyphenanthrene (2-PHEN) with MetS (OR: 1.37, 95% CI: 1.19–1.59, P < 0.001). Both identified 2-PHEN significant chemical positively associated WQS showed association overall three categories MetS, highest being 2-PHEN. Stratified demonstrated different subgroups. Notably, in subgroup female (OR = 1.40, 1.08–1.83, 0.05), 2-PHEN, 2,5-dichlorophenol (2,5-DCP), 2-hydroxynaphthalene (2-NAP), mono-ethyl phthalate (MEP) primary contributions Combined groups was an increased risk group exhibiting most pronounced emerging key chemical, underscoring public health concerns regarding risks endocrine-disrupting (EDCs) diseases.

Language: Английский

Citations

0
Exposure to polycyclic aromatic hydrocarbons and risk of abnormal liver function: The mediating role of C-reactive protein DOI
Yating Wang, Erxiong Zhu, Xiaoyan Zhu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 298, P. 118283 - 118283

Published: May 10, 2025

Language: Английский

Citations

0
Exposure to polycyclic aromatic hydrocarbons, heavy metals, and per- and polyfluoroalkyl substances and their associations with serum lipid profiles in the general Korean adult population DOI Creative Commons

Sanghee Shin,

Youlim Kim,

Yunsoo Choe

et al.

Environmental Health, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 11, 2025

Previous studies on associations between polycyclic aromatic hydrocarbons (PAHs) and lipid profiles are limited. We investigated the urinary PAH metabolites serum using a representative sample of Korean adults. This study utilized data from National Environmental Health Survey (2018-2020) (n = 2,516). The metabolites, heavy metals, per- polyfluoroalkyl substances (PFASs), which ubiquitous pollutants, with indicators dyslipidemia types were evaluated linear logistic regression models, respectively. examined mixture PFASs quantile g-computation analyses. A doubling 1-hydroxypyrene (1-OHP) concentrations was associated higher total cholesterol (TC) [β 2.50 mg/dL, 95% confidence interval (CI): 1.09, 3.91], low-density lipoprotein (LDL-C) (β 2.39 CI: 1.14, 3.63), non-high-density (non-HDL-C) 2.13 0.77, 3.49). 1-OHP also linked to odds high TC [odds ratio (OR) 1.15, 1.02, 1.30]. Additionally, 2-naphthol (OR 1.00, 1.29) LDL-C 1.27, 1.06, 1.51). Lead levels TC, LDL-C, non-HDL-C, high-density (HDL-C), as well non-HDL-C. Mercury TC. Several PFASs, such perfluorooctanoic acid, perfluorononanoic perfluorodecanoic profiles. HDL-C concentrations. LDL-C. Concentrations unfavorable in general adult population.

Language: Английский

Citations

0
The key metabolic signatures and biomarkers of polycyclic aromatic hydrocarbon-induced blood glucose elevation in chinese individuals exposed to diesel engine exhaust DOI Creative Commons
Yuanyuan Chen, Yanting Li, Wen Gu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116997 - 116997

Published: Sept. 10, 2024

Language: Английский

Citations

1
Impact of urinary PAHs on psoriasis risk in U.S. adults: Insights from NHANES DOI Creative Commons

Jiang-Hui Li,

Xiaoning Yan, Jiaying Fu

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0314964 - e0314964

Published: Dec. 5, 2024

Objective Exposure to environmental pollutants is increasingly recognized as a risk factor for the development of psoriasis. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in air and might induce reactions such oxidative stress. Nevertheless, it still unclear if PAHs have any influence on prevalence psoriasis over entire population United States. The objective this study was assess association between urine Methods research included 3,673 individuals aged 20 years or older who participated 2003–2006 2009–2012 National Health Nutrition Examination Surveys (NHANES). We employed logistic regression models evaluate relationship levels PAH metabolites smoothed curve fitting illustrate concentration-response relationship. Additionally, subgroup interaction analyses were conducted elucidate these associations. Furthermore, we weighted quartile sum (WQS) regressions examine distinct effects individual mixed However, important note that NHANES sample may be subject selectivity self-reporting bias, which data’ generalisability. Results observed highest tertiles 2-NAP 2-FLU had 63% (95% CI 1.02, 2.61) 83% 1.14, 2.96) higher odds with prevalence, respectively. Meanwhile, tertile 2 3 3-PHE also significantly associated psoriasis, 65% 1.01, 2.69) 14% 1.17, 3.00), revealed significant correlation specific groups, including males, 40–60 years, BMI > 30, those hyperlipidemia. In WQS model, positive found combination (OR 1.43, 95% 1.11, 1.84), being most prevalent component across all mixtures (0.297). Conclusions Our findings indicate adults. Among metabolites, demonstrated prominent impact. Controlling exposure, an strategy minimizing exposure contaminants lowering critical raising public knowledge about health preserving health.

Language: Английский

Citations

0