The relationship of serum klotho levels and triglyceride glucose index-related indicators DOI Creative Commons
Yaoyao Zhou, Yaqi Wang,

Fangli Li

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 5, 2024

Klotho, an anti-aging protein, is linked to energy metabolism. There limited research on the association of serum klotho and triglyceride glucose (TyG) index-related indicators. Our aims investigate relationship with TyG-BMI (body mass index), TyG-WC (waist circumference), TyG-WHtR (waist-to-height ratio). From 2007 2016, we examined 6,370 participants in National Health Nutrition Examination Survey (NHANES). The enzyme-linked immunosorbent assay (ELISA) was utilized measure klotho. We calculated TyG-BMI, TyG-WC, based fasting triglycerides, glucose, BMI, WC, WHtR. Multiple linear regression analysis used evaluate TyG-WHtR. Additionally, generalized additive model (GAM) smoothing curves were nonlinear relationships. A piecewise also test for threshold effects determine breakpoints. Finally, potential independent associations further explored using subgroup analysis. observed a statistically significant difference levels across different quartiles population. Based multiple analysis, negatively associated TyG-related between segmented revealed that breakpoints 5.42, 6.67, 1.89, respectively. Subgroup showed indicators interacted gender diabetes. In this study, negative identified Further needed clarify mechanisms may link

Language: Английский

Independent and Combined Associations of Urinary Heavy Metal Exposures with Serum α-Klotho in Middle-Aged and Older Adults DOI Creative Commons
Xinliang Zheng,

Wenxin Zhou,

Zhuoying Jiang

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 237 - 237

Published: March 24, 2025

α-Klotho is an anti-aging protein linked to various age-related diseases. Environmental metal exposure has been associated with oxidative stress and aging, but its effect on levels remains unclear. This study investigated the relationship between urinary concentrations serum using data from National Health Nutrition Examination Survey (NHANES) 2007–2016 cycles. A total of 4071 adults aged 40 79 years were included in analysis. After adjusting for potential confounders, positive associations found barium (Ba), cesium (Cs), molybdenum (Mo), while tungsten (W) uranium (U) negatively correlated levels. The combined effects multiple metals further analyzed qgcomp model, which demonstrated a negative correlation increased mixtures Specifically, U, arsenic (t-As), W, cadmium (Cd), antimony (Sb), lead (Pb) contributed reduction levels, Ba, Cs, dimethylarsinic acid (DMA), Mo, thallium (Tl), cobalt (Co) positively These findings suggest that certain metals, particularly combination, may reduce potentially accelerating aging processes. Further studies should investigate underlying mechanisms responsible these associations.

Language: Английский

Citations

0
Obesity affects the association between Serum Klotho and age-related hearing loss: A cross-sectional study DOI
Jingchao Yan, Ling Li, Qing Ye

et al.

Obesity Research & Clinical Practice, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Association between triglyceride-glucose index and phenotypic age acceleration: a cross-sectional study based on NHANES database DOI Creative Commons

Zhili Zhao,

Yan Liang

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: May 1, 2025

Objective To investigate the association between triglyceride-glucose (TyG) index and phenotypic age acceleration (PhenoAgeAccel), given emerging importance of biological aging as a health determinant role insulin resistance in aging-related processes. Methods This cross-sectional study analyzed data from 13,291 adults aged ≥20 years National Health Nutrition Examination Survey (1999–2010). The TyG served exposure variable, calculated fasting triglycerides glucose levels. PhenoAgeAccel, derived clinical biomarkers, was outcome variable. Analyses adjusted for demographic, socioeconomic, health-related covariates. Results A significant non-linear relationship observed with an inflection point at 9.60. In fully model, each unit increase associated 2.21 PhenoAgeAccel (95% CI: 1.99, 2.43). stronger above (β = 8.21, 95% 7.59, 8.82) compared to below it 0.56, 0.29, 0.83). Conclusion Higher levels are significantly accelerated aging, particularly threshold These findings suggest metabolic processes potential interventional strategies.

Language: Английский

Citations

0
Association between triglyceride glucose index and biological aging in U.S. adults: National Health and Nutrition Examination Survey DOI Creative Commons

Liya Pan,

Jin Li

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 28, 2025

Insulin resistance (IR) has been reported to be associated with aging; however, few studies have investigated the relationship between IR and biological age (BA). The Triglyceride–glucose (TyG) index is a recognized marker of IR. Currently, there insufficient evidence regarding TyG aging. This study aims provide deeper insights into connections We conducted cross-sectional using data from National Health Nutrition Examination Survey (NHANES), including 12,074 adults (aged 20 older) 2001–2010 2015–2018 cycles. Comprehensive BA were extracted for analysis. To explore BA, linear regressions employed, while logistic regression models used examine association accelerated Additionally, trend tests, subgroup analyses, smoothed fitted curves assess robustness findings. included participants mean 46.91 years (SD, 16.64); these, 50.25% female 49.75% male. Each 1-unit increase in was 1.64-year rise Klemera–Doubal method (KDM) 117% higher risk Similarly, each corresponded 0.40-year phenotypic age, resulting 15% analysis also revealed nonlinear positive relationships aging, particularly KDM (P non-linearity < 0.001) = 0.005), turning point at 8.66. Across all subgroups, consistently showed correlation even presence significant interactions. There Higher levels are linked increased greater

Language: Английский

Citations

0
Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015–2020 DOI Creative Commons
Miao Sun,

Shuang Bao

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Nov. 29, 2024

It is crucial to identify biomarkers that influence the aging process and associated health risks, given growing severity of global population issue. The objectives our research were evaluate cardiac metabolic index (CMI) as a novel biomarker for identifying individuals at increased risk accelerated biological assess its use in guiding preventive strategies aging-related risks.

Language: Английский

Citations

1
The relationship of serum klotho levels and triglyceride glucose index-related indicators DOI Creative Commons
Yaoyao Zhou, Yaqi Wang,

Fangli Li

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Dec. 5, 2024

Klotho, an anti-aging protein, is linked to energy metabolism. There limited research on the association of serum klotho and triglyceride glucose (TyG) index-related indicators. Our aims investigate relationship with TyG-BMI (body mass index), TyG-WC (waist circumference), TyG-WHtR (waist-to-height ratio). From 2007 2016, we examined 6,370 participants in National Health Nutrition Examination Survey (NHANES). The enzyme-linked immunosorbent assay (ELISA) was utilized measure klotho. We calculated TyG-BMI, TyG-WC, based fasting triglycerides, glucose, BMI, WC, WHtR. Multiple linear regression analysis used evaluate TyG-WHtR. Additionally, generalized additive model (GAM) smoothing curves were nonlinear relationships. A piecewise also test for threshold effects determine breakpoints. Finally, potential independent associations further explored using subgroup analysis. observed a statistically significant difference levels across different quartiles population. Based multiple analysis, negatively associated TyG-related between segmented revealed that breakpoints 5.42, 6.67, 1.89, respectively. Subgroup showed indicators interacted gender diabetes. In this study, negative identified Further needed clarify mechanisms may link

Language: Английский

Citations

0