Journal of Bodywork and Movement Therapies, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 17, 2025
This study examined the relationship between gallstones and estimated glucose disposal rate (eGDR) in people United States possible mediating function of body mass index (BMI). Data came from National Health Nutrition Examination Survey (NHANES), conducted 2017 March 2020. Logistic regression, subgroup analysis, smoothed curve fitting, causal mediation studies were among statistical techniques used to examine participant data. There 595 subjects with a gallstone diagnosis out 5,656 total. A significant negative association eGDR was observed by fully adjusted multivariate logistic regression analysis an OR 0.90 95% confidence interval (CI) (0.83, 0.98). The indicated that BMI accounted for 58.58% occurrence gallstones. identified substantial non-linear levels, acting as factor. fresh viewpoint on therapy prevention is offered these findings.
Language: Английский
Citations
1
Nature and Science of Sleep, Journal Year: 2025, Volume and Issue: Volume 17, P. 143 - 155
Published: Jan. 1, 2025
Simple and affordable methods for evaluating Insulin Resistance (IR) have been suggested, such as the Triglyceride-Glucose (TyG) index its variants, including TyG-Body Mass Index (TyG-BMI), TyG-Waist Circumference (TyG-WC), TyG-Waist-to-Height Ratio (TyG-WHtR). The aim of this study is to investigate relationship between these TyG-related indices, which measure IR, Obstructive Sleep Apnea (OSA). This analyzed NHANES data from 2007-2008, 2015-2016, 2017-2020. TyG derivatives were evaluated continuous categorical variables in relation OSA using multivariable logistic regression models. Subgroup analyses, dose-response relationships, threshold effects explored, diagnostic performance indices was assessed AUC curves. included 8,374 participants. fully adjusted Model 3 analysis (Note: Body not TyG-BMI) showed a positive correlation all four indices. All indicators statistically significant relationships with when grouped into quartiles (TyG: AOR = 1.448, 95% CI: 1.260-1.663; TyG-BMI: 3.785, 3.319-4.317; TyG-WC: 2.089, 1.629-2.677; TyG-WHtR: 1.913, 1.548-2.363). revealed stronger association TyG-WHtR 41-59 age group (AOR 1.459, 1.254-1.698) low-income 1.451, 1.241-1.698). linear OSA, while TyG-BMI, TyG-WC, exhibited nonlinear relationships. capability highest an 0.647. confirms strong associations particularly demonstrates predictive power risk. Future longitudinal studies are recommended further enhance management resource-constrained environments.
Language: Английский
Citations
1
BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 29, 2025
Gallstone disease (GSD) is associated with obesity. The Cardiometabolic Index (CMI), a metric that accurately assesses central adiposity and visceral fat, has not been extensively studied in relation to GSD risk. This study investigates the link between CMI incidence U.S. adults. utilized data from National Health Nutrition Examination Survey(NHANES)(2017-2020) assess association GSD, adjusting for confounders such as age, sex, race, chronic diseases, lifestyle factors. Multivariable logistic regression models subgroup analyses were employed. Generalized Additive Models (GAM) advanced curve fitting techniques used explore potential non-linear relationships, threshold effects determined via piecewise linear if relationships identified. Receiver Operating Characteristic (ROC) curves evaluated compared predictive performance of CMI, Body Mass (BMI), Waist Circumference (WC), establishing optimal cutoff values along their sensitivity specificity. included 3,706 participants, whom 10.6% (392) had GSD. Participants showed significantly higher (0.57 vs. 0.44, P = 0.0002). group more females older adults, increased risks hypertension, diabetes, serum cholesterol creatinine levels, risk cancer. Logistic analysis revealed was greater (OR 1.19, 95% CI 1.02-1.38, < 0.0001). ROC demonstrated superior (AUC 0.778), outperforming conventional metrics like BMI WC. GAM indicated positive correlation an 0.996. Subgroup found strongest among females, individuals aged 20-39, non-Hispanic Whites, those without history coronary heart disease, alcohol consumers. Our reveals nonlinear value Despite limitations sample size constrained fully adjusted model, after confounding factors, AUC predicting using reached 0.778, surpassing traditional metrics. These findings underscore importance critical factor emphasize necessity targeted interventions high-risk populations.
Language: Английский
Citations
1
Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)
Published: Aug. 22, 2024
The chronic digestive condition gallstones is quite common around the world, development of which closely related to oxidative stress, inflammatory response and abnormalities lipid metabolism. In last few years, as a novel biomarker metabolism, non-high-density lipoprotein cholesterol high-density ratio (NHHR) has garnered significant interest. However, its relationship with not been studied yet. 3,772 people, all under 50, were included in this study, their full data came from National Health Nutrition Examination Survey (NHANES) database for years 2017–2020. Information on was obtained through self-reported questionnaires. Smoothed curve fitting multifactorial logistic regression utilized evaluate connection NHHR gallstone formation incidence. Subsequently, subgroup analysis interaction tests applied. Finally, create prediction model, feature screening by absolute shrinkage selection operator (LASSO) used. resulting model displayed using nomogram. multivariate that accounted factors, there 77% increase likelihood every unit rise lnNHHR (OR 1.77 [CI 1.11–2.83]). Following stratification, Q4 level substantially more linked risk than Q1 1.86 1.04–3.32]). This correlation stronger women, people 35, smokers, abstainers alcohol, non-Hispanic White those excessively high cholesterol, COPD, without diabetes. After screening, predictive visualized nomogram constructed an AUC 0.785 (CI 0.745–0.819), assessed DCA be clinically important. group ≤ 50 age, elevated levels higher incidence gallstones. several specific groups such females, 35 so on. Predictive models have potential clinical value assessing formation.
Language: Английский
Citations
8
Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 25, 2025
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 30, 2025
Background Research indicates that the ratio of fasting blood glucose (FBG) to serum high-density lipoprotein cholesterol (HDL-C) (GHR) can accurately predict many diseases. Nevertheless, relationship between GHR and risk gallbladder stones remains unclear. This study investigates possible incidence stones. Methods research used information gathered from National Health Nutrition Examination Survey (NHANES) March 2017 2020. A calculation was made determine by dividing level HDL-C level. Several statistical methods, including analysis threshold effects, smoothed curve fitting, multiple logistic regression modeling, subgroup analysis, were utilized investigate connection gallstones. Results In 3898 U.S. adults, significantly positively associated with prevalence a fully adjusted model, increased 7% each 1-unit increase in (OR [95% Cl] = 1.07 [1.02, 1.14]). Compared members low group, those high group had 100% higher likelihood getting CI] 2.00 [1.31, 3.04]), this stabilizing always present different subgroups. With help smooth also showed there formed like an upside-down L shape The effect revealed inflection point 4.28. Conclusion results inverted L-shaped Keeping levels within certain range is lower gallstones general population.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: Feb. 19, 2025
Gallstones are a common gastrointestinal disease worldwide, associated with significant public health burdens. Obesity and fat distribution recognized as major risk factors for gallstone formation, yet traditional anthropometric indices such BMI WC have limitations in reflecting its metabolic consequences. Relative Fat Mass (RFM), novel index, may provide more accurate predictions of risk, but association formation remains underexplored. This study utilized data from NHANES 2017-2020, including 6,084 participants aged ≥20 years, to investigate the relationship between RFM risk. Multivariable logistic regression smooth curve fitting were used assess this association. RFM's predictive ability was compared using ROC decision analysis (DCA). LASSO AIC-based multivariable employed construct prediction model. Each one-unit increase 11% higher gallstones (OR: 1.11; 95% CI: 1.08-1.13). The revealed linear gallstones. demonstrated superior (AUC = 0.705) BMI, WC, WWI, BRI. model, incorporating age, RFM, diabetes, waist circumference, alcohol consumption, achieved good performance 0.738) sensitivity specificity 70 66%, respectively. is strongly outperforms measures prediction. presents model that serves useful instrument recognizing populations at elevated facilitating focused interventions, especially among those prevalent occurrence obesity disturbances. These findings support potential an effective measure clinical settings reducing burden gallstone-related diseases.
Language: Английский
Citations
0
BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 24, 2025
Gallstones are a common disease of the digestive system, and its complications pose serious risks to human health impose significant economic burden on society. Inadequate dietary potassium intake may be associated with development gallstones, however, there is lack current epidemiological research this topic. The purpose was preliminarily exploration relationship between prevalence providing direction for next step quantitativeanalysis association gallstones. Data from National Health Nutrition Examination Survey (NHANES) spanning 2017 2020 were used cross-sectional analysis. presence gallstones assessed based NHANES questionnaire data corresponding time frame. To investigate link consumption likelihood developing multiple logistic regression models used. Subgroup analyses conducted variables such as age, gender, poverty-to-income ratio (PIR), body mass index (BMI), hypertension, diabetes, supplement use, physical activity. An analysis linear associations carried out using smoothing curves. study comprised 6,223 participants aged 20 years older, excluding pregnant individuals. Among these participants, 671 diagnosed In final adjusted model, 95% confidence interval (CI) 0.70 0.93, it determined that gallstone incidence negatively correlated (OR = 0.81, p 0.003). Individuals in highest tertile experienced 31% lower risk compare those lowest 0.69, CI: 0.51–0.94, 0.017). Model 1, exhibited an inverse intake. This negative persisted even after stratifying by PIR, BMI, Sensitivity demonstrated stability relationship. Our revealed increased Nevertheless, additional prospective studies required confirm precise level long-term effects metabolism formation.
Language: Английский
Citations
0
BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 25, 2025
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: April 30, 2025
Background Gallstones are a prevalent condition that can lead to significant morbidity and healthcare costs. Relative fat mass (RFM), as potential marker of body distribution, may offer insights beyond traditional metrics like index (BMI) waist circumference. This study aims investigate the association between RFM gallstone prevalence in U.S. population. Methods The cohort comprised 6,881 participants obtained from National Health Nutrition Examination Survey (NHANES) conducted 2017 2020. Participants were stratified into quartiles (Q1–Q4) based on their RFM. To evaluate associations, multivariable logistic regression analyses employed assess odds ratios (OR) for risk across different Additionally, restricted cubic spline analysis was ascertain relationship trend while subgroup examined interactions age, sex, race, education level, lifestyle factors. Results revealed associations within higher (Q3 Q4), with ORs 2.58 (95% CI: 1.65, 4.04) 6.30 3.63, 10.93), respectively, compared Q1. findings consistently indicated RFM, particularly Q4, is strong predictor risk, demonstrating superior predictive performance relative circumference BMI, evidenced by an AUC 0.702. Conclusion Elevated noteworthy studied population, suggesting its utility clinical assessment frameworks. Future research should focus elucidating underlying mechanisms driving this exploring RFM's applicability pragmatic tool practice stratification.
Language: Английский
Citations
0