Evaluating body roundness index and systemic immune inflammation index for mortality prediction in MAFLD patients

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 2, 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a major cause of liver-related morbidity and mortality, contributing to both cardiovascular non-cardiovascular deaths. The Body Roundness Index (BRI) Systemic Immune-Inflammation (SII) have emerged as predictors adverse outcomes in metabolic diseases. This study investigates the association between BRI, SII, mortality risk MAFLD patients. A nationwide retrospective cohort was conducted using data from NHANES database (January 1999–December 2018), including patients diagnosed with MAFLD. BRI SII were calculated at baseline. Cox proportional hazards models assessed these indices all-cause, cardiovascular, adjusting for confounders. Among 12,435 participants MAFLD, 3,381 (27.2%) classified into low group, 2,889 (23.2%) high 2,802 (22.5%) 3,363 (27.1%) group. Compared group demonstrated significantly higher all-cause an adjusted hazard ratio (HR) 1.89. For HR 2.31, while 1.78. exhibited highest mortality. are independent patients, their combined use enhances stratification. Integrating clinical practice could improve personalized management strategies this high-risk population.

Language: Английский

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Association between systemic immune inflammation index and adolescent obesity in a cross-sectional analysis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 22, 2025

Abstract Obesity is a prevalent health issue among adolescents, characterized by chronic low-grade inflammation, which increases the risk of developing various diseases in future. The systemic immune-inflammation index (SII) serves as an indicator inflammation and immune response. This study conducted cross-sectional analysis using data from National Health Nutrition Examination Survey (NHANES) 2007 to 2016, including 5,676 participants. A multivariate logistic regression model, Generalized Additive Models (GAM), subgroup were used examine relationship between obesity SII. results revealed significant positive correlation log SII adolescent (1.254 [1.024–1.537]). Furthermore, increased with higher quartiles Subgroup interaction tests showed that this association persisted across factors, female gender, race (Non-Hispanic White Mexican American), non-hyperlipidemia, normal white blood cell count, PIR < 1. Additionally, U-shaped was observed, turning point at 6.410. findings suggest increase significantly associated adolescents. However, further validation through large-scale prospective studies needed.

Language: Английский

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An inverted U-shaped association between high-sensitivity C-reactive protein and the albumin ratio and hepatic steatosis and liver fibrosis: a population-based study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 15, 2025

Background The high-sensitivity C-reactive protein to albumin (CAR) ratio is a comprehensive measure of inflammation in vivo . Hepatic steatosis and fibrosis are significantly correlated with inflammation. present study aimed explore the possible associations between CAR hepatic American population. Methods population involved National Health Nutrition Examination Survey (NHANES) participants from 2017 2020. natural logarithm CAR, calculated as Ln(CAR) base “e,” was used for further analyses. relationships controlled attenuation parameter (CAP) liver stiffness measurement (LSM) were investigated through multivariate linear regression analysis. Interaction subgroup analysis identified factors affecting these variables. Nonlinear elucidated by smoothing curves threshold effect Receiver operating characteristic (ROC) curve performed evaluate predictive performance non-alcoholic fatty disease (NAFLD). results adjusted U.S. estimates. Results included total 7,404 individuals. positively CAP fully model, an value β = 1.827 (95% CI, 0.611, 3.042). A more pronounced positive association observed among BMI ≥ 25 kg/m 2 An inverted U-shaped shown smooth fitting two-segment inflection point (−9.594). ROC showed that had moderate NAFLD (AUC 0.6895), sensitivity 0.7276 specificity 0.6092. No significant detected LSM. Conclusion We demonstrate relationship risk within demographic. Our suggest may serve valuable diagnostic tool NAFLD. Further prospective research necessary validate this conclusion.

Language: Английский

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Weight-adjusted waist index and its relationship with systemic inflammatory Index and metabolic indices in overweight and obese individuals: A cross-sectional study

Science Progress, Journal Year: 2025, Volume and Issue: 108(2)

Published: April 1, 2025

Background Obesity- characterized by excessive adiposity- is associated with various comorbidities, including metabolic, cardiovascular, and liver diseases. Chronic low-grade inflammation a key factor in complications obesity. This study aimed to investigate the associations between systemic inflammatory indices (SIIs) weight-adjusted waist index (WWI), alongside metabolic function biomarkers overweight obese individuals. Method cross-sectional included 350 or participants (body mass (BMI) ≥ 25 kg/m 2 ) from both genders. Weight, height, waist, hip, neck circumferences were measured BMI, WWI, ratios of height (WHtR) hip (WHR) estimated. Fasting blood samples taken assess SII as well parameters. Results In this study, males had significantly higher weight WC compared females, whereas mean level WWI (p < 0001) WHtR = 0.01) women greater than men. A significant correlation was observed (r 0.113, p 0.039), other HbA1c levels −0.117, 0.033) monocyte-to-lymphocyte ratio (MLR), fasting sugar (FBS) neutrophil-to-lymphocyte NLR 0.110, 0.041). quartiles showed differences aspartate aminotransferase AST 0.001), variations MLR also −0.112, 0.043). Conclusion Our results reveal strong correlations markers, SII, MLR, PLR, important obesity measures, parameters individuals

Language: Английский

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Integrating adipsin with novel cardiometabolic and inflammatory indices for enhanced early prediction of gestational diabetes mellitus: a prospective cohort study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 2, 2025

Early identification of individuals at risk for gestational diabetes mellitus (GDM) is essential mitigating its adverse effects on both maternal and foetal health. This study aimed to evaluate the predictive value cardiometabolic index (CMI), systemic inflammation response (SIRI), serum adipsin levels GDM. A total 1660 pregnant women were enrolled in this conducted Suzhou, China. Baseline clinical data, including blood glucose levels, lipid profiles, cell counts, collected 12 weeks gestation. GDM was diagnosed between 24 28 Logistic regression receiver operating characteristic (ROC) curve analyses performed assess associations performance CMI, SIRI, Compared with non-GDM participants, those exhibited significantly higher CMI SIRI values lower baseline. Increased as well reduced independently associated a unadjusted adjusted models (all P < 0.05). The composite model incorporating all three biomarkers achieved area under (AUC) 0.918 compared individual (AUC = 0.825), 0.802), 0.724). are risk, their combination provides promising multi-biomarker strategy early prediction. Further studies needed validate these findings diverse populations.

Language: Английский

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Associations between systemic immune-inflammatory index and visceral adipose tissue area: results of a national survey

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 16, 2025

Global health issues related to obesity are growing. Visceral adipose tissue (VAT) significantly contributes complications associated with obesity. Reducing accumulation can improves inflammation. However, it is still unknown how the systemic immune-inflammation index (SII) and VAT area related. With help of multivariate linear regression smooth curve fitting, relationship between SII was explored data from 2013 2014 National Health Nutrition Examination Survey (NHANES). Analyzing subgroups testing for interaction were used investigate whether accurate across demographics. From 20 59 years age, 3,290 individuals observed have a positive correlation area. In accordance fully adjusted model, increased by 9.34 cm2 every unit increase in log [β = 9.34, 95% CI (4.02, 14.67)]. highest quartile SII, 5.46 5.46, (2.21, 8.71)] higher than that lowest quartile. Additionally, population overweight or obese showed stronger correlation. has US adults. may be valuable clinical applications evaluate severity

Language: Английский

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Exploring the link between inflammation and brain function after metabolic‐bariatric surgery: A year‐long fMRI study

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Metabolic-bariatric surgery (MBS) transcends weight loss and offers wide-ranging health benefits, including positive effects on brain function. However, the mechanisms behind these remain unclear, particularly in context of significant postoperative changes inflammatory profile characteristic MBS. Understanding how inflammation influences function can enhance our decision-making patient eligibility for MBS create new opportunities to improve outcomes this popular treatment. To identify regions where spontaneous neural activity functional connectivity are linked with evolving following We investigated relationship between perioperative ratio interleukin (IL)-6 IL-10 both amplitude low-frequency fluctuation (ALFF) across 375 regions. examined 36 patients at three time points: 1 week before, 3 12 months after laparoscopic sleeve gastrectomy. Initially, IL-6/IL-10 increased during early period but then decreased levels lower than preoperative values year surgery. observed that ALFF four subcortical structures a rising declining ratio. Conversely, 16 cortical displayed opposite trend. Additionally, left insula bilateral medial prefrontal cortex Our study is first significantly Importantly, many discovered areas were previously shown be involved pathogenesis obesity or targets contemporary medical treatments. Consequently, findings offer valuable insights future research, especially potential therapeutic opportunities.

Language: Английский

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Higher systemic immune-inflammation index is associated with increased risk of Parkinson’s disease in adults: a nationwide population-based study

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: Feb. 7, 2025

This study aimed to explore the association between a new inflammatory marker, systemic immune-inflammation index (SII), and risk of Parkinson's disease (PD) in adult population. A cross-sectional design was used, participants were recruited from National Health Nutrition Examination Survey (NHANES) 2005 2020. Three logistic regression models used SII PD, subgroup analysis sensitivity used. In addition, restricted cubic spline (RCS) dose-response relationship PD. Receiver operating characteristic (ROC) curves diagnostic value for total 54,027 adults (mean age 35 years) included this study. The results showed that after adjusted all covariates, compared with Q1 group (lowest quartile SII), PD Q3 (OR = 1.82, 95%CI 1.20-2.82, p < 0.001) Q4 increased 2.49, 1.69-3.77, 0.001), p-trend 0.001. After excluding individuals any missing values, also found positive Subgroup more significant women, younger than 60 years old, non-smokers, alcohol drinkers, non-obese, without history stroke, diabetes, or coronary heart disease. there had an acceptable (AUC 0.72). is positively correlated prevalence population, can help differentiate non-PD cases.

Language: Английский

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Association between systemic immune-inflammation index and central obesity in pediatric populations: a cross-sectional and cohort study

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 19, 2025

Central obesity in children represents a significant public health concern due to its strong association with an elevated risk of metabolic and cardiovascular disorders. The systemic immune inflammation index (SII) has been implicated the pathophysiology obesity-related chronic inflammation. Despite potential relevance, specific relationship between central SII pediatric population remains insufficiently explored. objective this study was examine obesity, particular focus on as predictor means preventing at early stage life. Waist-to-height ratio (WHtR), subcutaneous fat, visceral fat were employed proxies. defined according WHtR cutoff value 0.46. implications examined sample 4,730 individuals 2021 validated through prospective involving 1,425 subjects 2023. Cross-sectional associations using binomial logistic regression models generalized linear models. restricted cubic spline used explore non-linear indicators. In study, we modified Poisson model investigate causal obesity. Cross-sectionally, adolescents highest quartile levels exhibited greatest for obesity(OR=3.07, 95% CI:2.45~3.87) when compared those lowest quartile. Subgroup analyses showed that higher associated Longitudinally, found have developing (RR=1.83, CI:1.18~2.83) over time.

Language: Английский

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Systemic inflammation as a mediator in the link between obesity and depression: Evidence from a nationwide cohort study

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 5, 2025

Obesity and depression are major public health issues with a complex, bidirectional relationship potentially involving systemic inflammation. Using diverse sample from the National Health Nutrition Examination Survey (NHANES) (n = 11,324; weighted population 456,457,366), we examined associations between obesity, inflammation, depression. was classified by Body Mass Index (BMI), depressive symptoms were assessed Patient Questionnaire-9 (PHQ-9), inflammation measured using markers like Neutrophil-to-Lymphocyte Ratio (NLR), Systemic Inflammation Response (SIRI), Immune-Inflammation (SII). Weighted logistic regression models used to assess relationships Linear evaluated BMI's association markers, Restricted Cubic Spline (RCS) analysis explored their interrelationships. Subgroup analyses interaction tests conducted, mediation role of in mediating obesity-depression association. Class III obesity associated higher inflammatory marker levels increased risk. Mediation showed NLR, SIRI, SII mediated 5.2%, 5.9%, 6.1% relationship. partially mediates

Language: Английский

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