Identification of prognostic significant markers of early diagnosis of obesity and metabolic disorders DOI
Mikhaĭlova Aa, К.В. Котенко, С. Н. Нагорнев

et al.

Problems of Balneology Physiotherapy and Exercise Therapy, Journal Year: 2024, Volume and Issue: 101(6), P. 71 - 71

Published: Jan. 31, 2024

Obesity, being a global epidemic of the 21st century, increases likelihood various diseases and conditions that are associated with increased mortality. Given risks obesity throughout life, identifying early predictors its development is priority task prevention. Assessment prognostic significance laboratory parameters, functional tests instrumental examination data for diagnosis metabolic disorders. The studies were conducted at Scientific Clinical Center 1 B.V. Petrovsky Russian Surgery participation 77 patients (43 men 34 women) aged 33 to 65 years. After signing voluntary informed consent special study processing their personal data, all underwent comprehensive clinical, examination. design provided three-time an interval 6 12 months. To search disorders, we used algorithm constructing mathematical model multiple regression. dynamics body mass index insulin resistance served as resulting feature. build predictive model, matrix independent variables was formed, including parameters characterizing biochemical status patients, severity systemic inflammation, composition, well arterial stiffness vascular condition based on results ultrasound duplex scanning brachiocephalic arteries. choice most informative set act provides achieving maximum additive effect in explaining variance construction actual regression selection factors carried out using method sequential hypothesis testing. As result applying testing, three (predictors) identified predict degree BMI increase four accuracy developed verified final stage study, showed high information content. Two clusters identified: cluster risk includes inflammatory response index, triglyceride-glucose blood leptin level. biomarkers disorders consists atherogenicity coefficient, malondialdehyde level, inflammation roundness index.

Language: Английский

Medical Nutrition Therapy in Dermatological Diseases: A Joint Consensus Statement of the Italian Association of Dietetics and Clinical Nutrition (ADI), the Italian Society of Dermatology and Sexually Transmitted Diseases (SIDeMaST), the Italian Society of Nutraceuticals (SINut), Club Ketodiets and Nutraceuticals “KetoNut-SINut” and the Italian Society of Endocrinology (SIE), Club Nutrition, Hormones and Metabolism DOI Creative Commons
Luigi Barrea, Ludovica Verde, Giuseppe Annunziata

et al.

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: May 13, 2025

Abstract Summary Dermatological diseases such as acne, hidradenitis suppurativa (HS), and psoriasis are driven by chronic inflammation oxidative stress. Emerging evidence highlights the role of nutrition in modulating these conditions, particularly through dietary patterns rich antioxidants, polyphenols, unsaturated fatty acids. Recent Findings The Mediterranean diet (MedDiet) has demonstrated potential benefits due to its anti-inflammatory immunomodulatory effects, while very low-energy ketogenic therapy (VLEKT) shown promise rapidly improving disease severity. Specific nutrients, including omega-3 acids, probiotics, micronutrients, may further contribute management. However, current literature is limited small-scale studies lack standardized guidelines. Purpose Review This Consensus Statement , developed collaboratively Italian Association Dietetics Clinical Nutrition (ADI), Society Dermatology Sexually Transmitted Diseases (SIDeMaST), Nutraceuticals (SINut), Club Ketodiets “KetoNut-SINut” Endocrinology (SIE), Nutrition, Hormones Metabolism aimed establish an evidence-based framework for medical (MNT) most common inflammatory skin diseases, HS psoriasis.

Language: Английский

Citations

0
Impact of Obesity Severity on Hepatic Steatosis and Systemic Inflammatory Markers: A Comparative Analysis Across Obesity Classes DOI Creative Commons
Seyit Uyar, Nizameddin Koca, Alihan Oral

et al.

DAHUDER Medical Journal, Journal Year: 2024, Volume and Issue: 4(4), P. 77 - 82

Published: Oct. 29, 2024

Introduction: Obesity has become a global health issue, with its prevalence steadily increasing. It is closely linked to several metabolic disorders, cardiovascular diseases, non-alcoholic fatty liver disease, and chronic low-grade inflammation can progress more severe conditions. This study evaluates the relationship between obesity inflammatory markers in individuals different levels. Methods: A cross-sectional was conducted among 50 patients categorized into three classes based on body mass index (BMI). Blood samples were taken evaluate markers, including white blood cell (WBC) count, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP). Results: There no statistically significant differences such as WBC, NLR, or CRP; trend toward higher CRP levels observed Class 3 obesity. Conclusion: In our study, association degree of Although sample size relatively small, it essential acknowledge that multifaceted condition, genetic variations may play role these results.

Language: Английский

Citations

0
A Randomized Controlled Trial on the Efficacy of 20% Human Albumin in Reducing Pleural Effusion After Cardiopulmonary Bypass DOI Open Access
Kaspars Šetlers,

Klaudija Aispure,

Maksims Zolovs

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(24), P. 7693 - 7693

Published: Dec. 17, 2024

Background/Objectives: Cardiopulmonary bypass can lead to hemodilution, causing a fluid shift the interstitial space. Albumin helps counteract intravascular movement extravascular space and reduces risk of complications associated with imbalance. Our main objective was evaluate effectiveness albumin addition in cardiopulmonary priming solution compared standard priming, focusing on its role reducing pleural effusion development. Methods: This single-center randomized controlled trial conducted at tertiary care hospital specializing cardiology cardiac surgery. It involved 70 individuals scheduled for elective open-heart All cases were randomly assigned into two groups 35 patients. The study group replaced 100 mL CPB 20% human albumin. We measured serum levels before after surgery, 6 12 h after, calculated colloid oncotic pressure. Thorax CT scans performed first postoperative day measure calculate volume. Results: led significant reduction development CPB. An level <35 g/L surgery showed increase development, sufficient maintain > g/L. Conclusions: suggests link between hypoalbuminemia early CPB, as well possible benefits adding crystalloid minimize

Language: Английский

Citations

0
Identification of prognostic significant markers of early diagnosis of obesity and metabolic disorders DOI
Mikhaĭlova Aa, К.В. Котенко, С. Н. Нагорнев

et al.

Problems of Balneology Physiotherapy and Exercise Therapy, Journal Year: 2024, Volume and Issue: 101(6), P. 71 - 71

Published: Jan. 31, 2024

Obesity, being a global epidemic of the 21st century, increases likelihood various diseases and conditions that are associated with increased mortality. Given risks obesity throughout life, identifying early predictors its development is priority task prevention. Assessment prognostic significance laboratory parameters, functional tests instrumental examination data for diagnosis metabolic disorders. The studies were conducted at Scientific Clinical Center 1 B.V. Petrovsky Russian Surgery participation 77 patients (43 men 34 women) aged 33 to 65 years. After signing voluntary informed consent special study processing their personal data, all underwent comprehensive clinical, examination. design provided three-time an interval 6 12 months. To search disorders, we used algorithm constructing mathematical model multiple regression. dynamics body mass index insulin resistance served as resulting feature. build predictive model, matrix independent variables was formed, including parameters characterizing biochemical status patients, severity systemic inflammation, composition, well arterial stiffness vascular condition based on results ultrasound duplex scanning brachiocephalic arteries. choice most informative set act provides achieving maximum additive effect in explaining variance construction actual regression selection factors carried out using method sequential hypothesis testing. As result applying testing, three (predictors) identified predict degree BMI increase four accuracy developed verified final stage study, showed high information content. Two clusters identified: cluster risk includes inflammatory response index, triglyceride-glucose blood leptin level. biomarkers disorders consists atherogenicity coefficient, malondialdehyde level, inflammation roundness index.

Language: Английский

Citations

0