Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 862 - 862
Published: Jan. 20, 2025
Vaccines
represent
an
essential
tool
for
the
prevention
of
infectious
diseases.
Upon
administration,
a
complex
interaction
occurs
between
vaccine
formulation
and
recipient’s
immune
system,
ultimately
resulting
in
protection
against
disease.
Significant
variability
exists
individual
population
responses
to
vaccination,
these
differences
remain
focus
ongoing
research.
Notably,
well-documented
factors,
such
as
age,
gender,
genetic
predisposition,
influence
responses.
In
contrast,
effects
overweight
obesity
have
not
been
thoroughly
investigated.
The
evidence
indicates
that
high
body
mass
index
(BMI)
constitutes
significant
risk
factor
infections
general,
with
adipose
tissue
playing
crucial
role
modulating
response.
Furthermore,
suboptimal
levels
seroconversion
observed
among
individuals
obesity.
This
review
provides
plausible
examination
immunity
conferred
by
various
vaccines
status,
offering
comprehensive
analysis
mechanisms
enhance
vaccination
efficiency.
Language: Английский
The Modulatory Role of Bioactive Compounds in Functional Foods on Inflammation and Metabolic Pathways in Chronic Diseases
Foods,
Journal Year:
2025,
Volume and Issue:
14(5), P. 821 - 821
Published: Feb. 27, 2025
Chronic
diseases
are
major
contributors
to
global
morbidity
and
mortality.
More
than
70%
of
deaths
worldwide
caused
by
chronic
diseases,
including
cardiovascular
(CVDs),
obesity,
type
2
diabetes,
cancer.
These
characterised
low-grade
inflammation
metabolic
dysregulation.
Incorporating
functional
foods
into
daily
diet
has
been
suggested
as
a
complementary
strategy
promote
health
lower
the
risk
non-communicable
diseases.
Functional
foods,
known
that
confer
benefits
beyond
basic
nutrition,
have
reported
exhibit
preventive
therapeutic
such
anti-inflammatory
properties
for
human
health.
Therefore,
aim
this
state-of-the-art
review
will
synthesise
findings
from
recent
high-quality
studies
investigated
modulatory
role
some
commonly
bioactive
active
compounds,
polyphenols,
omega-3
fatty
acids,
probiotics,
prebiotics,
in
pathways.
Language: Английский