Association of triglyceride-glucose index and derived indices with cataract in middle-aged and elderly Americans: NHANES 2005–2008

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 14, 2025

Abstract Aim Explore the relationship between triglyceride-glucose (TyG) index, along with its derivative indices, and prevalence of cataracts. Methods Data from 20,497 participants in 2005–2008 National Health Nutrition Examination Survey (NHANES) were compiled. A final total 4,499 individuals met eligibility criteria. Cataract presence was assessed through a self-reported history cataract surgery. The TyG index derivatives—TyG-waist-to-height ratio (WHtR), TyG-neutrophil-to-lymphocyte (NLR), TyG-monocyte-to-lymphocyte (MLR), TyG-log platelet-to-lymphocyte (lgPLR), systemic inflammation (lgSII), TyG-systemic response (SIRI)—were calculated. Statistical analyses included multivariable logistic regression, restricted cubic spline (RCS) curves for nonlinear relationships, receiver operating characteristic (ROC) analysis. Results Higher indices significantly associated ( P < 0.001). Specifically, TyG-WHtR, TyG-NLR, TyG-lgPLR, TyG-lgSII, TyG-SIRI exhibited positive correlations prevalence, even after adjustment potential confounders (odds [OR] = 1.17; 95% confidence interval [CI]: 1.01, 1.37; 0.0403; 1.01; 1.00, 1.02; 0.0258; 1.08; 1.16; 0.0223; 1.03, 1.14; 0.001; 1.04; 0.0120). Furthermore, stratified analysis showed that 61–85 age group, TyG-lgPLR TyG-lgSII remained positively ([OR] 1.09; 0.024; 1.02, 1.13; 0.005). RCS revealed linear association these cataracts, no apparent threshold effect. ROC indicated TyG-MLR demonstrated highest predictive ability presence. Conclusion study results indicate TyG-related indicators cataracts middle-aged elderly individuals, suggesting markers may serve as practical biomarkers identifying high-risk individuals. Early detection management metabolic inflammatory factors could contribute to effective preventive strategies development population.

Language: Английский

Predictive value of the triglyceride-glucose index for coronary artery bypass grafting-acute kidney injury patients

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 21, 2025

Acute kidney injury (AKI) is a common and serious complication after coronary artery bypass grafting (CABG), significantly affecting patient outcomes. The triglyceride-glucose (TyG) index, marker of insulin resistance, has shown potential in predicting various metabolic cardiovascular conditions. This study aimed to evaluate the predictive value TyG index for AKI occurrence following CABG. retrospective, single-center included 3,260 patients who underwent Patients were categorized into non-AKI groups based on postoperative renal function. preoperative was calculated from fasting blood glucose triglyceride levels. further divided quartiles index. Logistic regression analysis used assess relationship between risk. Subgroup analyses spline employed explore interactions non-linear relationships. Of patients, 514 (15.8%) developed AKI. Baseline characteristics showed that had higher levels hemoglobin (Hb), alanine aminotransferase (ALT), aspartate (AST), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C), glucose, while brain natriuretic peptide (BNP) lower compared patients. confirmed an independent risk factor CABG, both as continuous variable (OR 1.034 [95% CI 1.017–1.050], p < 0.001) when grouped by quartiles. A observed, with significant increase exceeded 5.4. revealed this association consistent across multiple groups, including those stratified age, sex, BMI, extracorporeal circulation use, comorbidities such hypertension, diabetes, hyperlipidemia. predictor dose-response observed subgroups. Monitoring can help identify high-risk potentially guiding early intervention improving These findings underscore valuable tool clinical practice, warranting validation prospective studies.

Language: Английский