Elevated TyG index outperforms TyG-BMI in predicting delirium among non-diabetic sepsis patients DOI

Su-Juan Zhao,

Fu Wang, Guangdong Wang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Abstract Background The Triglyceride Glucose (TyG) index and TyG-Body Mass Index (TyG-BMI), recognized as validated surrogate markers of insulin resistance (IR), have demonstrated prognostic utility in various metabolic disorders. However, their potential predictive biomarkers for sepsis-associated delirium (SD) non-diabetic populations remains unexplored. This study aims to systematically evaluate compare the performance TyG TyG-BMI indices incidence among sepsis patients without diabetes mellitus. Methods Our included a comprehensive retrospective observational cohort analysis, utilizing an extensive dataset from Critical Care Medical Information Market IV (MIMIC-IV 2.2). population was divided into quartiles based on triglyceride-glucose TyG-body mass (TyG-BMI). primary outcome assessed at 28 days, secondary length ICU stay. To relationship between index, TyG-BMI, delirium, we employed Cox proportional hazards regression model, supplemented by constrained cubic spline function (RCS) analysis improve accuracy. In addition, Kaplan-Meier (KM) method used estimate survival probability, receiver operating characteristic (ROC) curve plotted ability two indicators predict delirium. Results A total 2,665 were identified database. model revealed that independently associated with 28-day (hazard ratio [HR], 1.354; 95% confidence interval [CI], 1.225–1.496). Similarly, also showed significant correlation incidence, HRs (95% CI) 1.009 (1.006–1.012), respectively. (K-M) cumulative increased higher or index. Based ROC exhibited better (AUC: 0.589) compared 0.566). effect occurrence remained consistent across subgroups, no interactions observed randomization factors. Additionally, incorporating base prediction slightly improved its capability 0.708 vs. 0.715 + index). Conclusion As continuous variable, both measures association risk critically ill sepsis, became most promising indicator stratification prevention strategies superior

Language: Английский

HOMA-IR and TyG index differ for their relationship with dietary, anthropometric, inflammatory factors and capacity to predict cardiovascular risk DOI Creative Commons
Domenico Sergi, Riccardo Spaggiari, Edoardo Dalla Nora

et al.

Diabetes Research and Clinical Practice, Journal Year: 2025, Volume and Issue: unknown, P. 112103 - 112103

Published: March 1, 2025

Language: Английский

Citations

1
Triglyceride-Glucose (TyG) Index in a Pediatric Non-Diabetic Cohort-Surrogate Marker of Insulin Resistance? DOI Creative Commons
Sridevi Devaraj,

D. Muthu Krishnan,

Xinpu Chen

et al.

Published: March 1, 2025

Original Research Articles Triglyceride-Glucose (TyG) Index in a Pediatric Non-Diabetic Cohort-Surrogate Marker of Insulin Resistance? Sridevi Devaraj *, Daksha Krishnan and Xinpu Chen Department Pathology & Immunology, Baylor College Medicine, Houston, TX 77030, USA * Correspondence: [email protected] Received: 22 January 2025; Accepted: 13 February Published: 1 March 2025 Abstract: The incidence diabetes obesity has reached epidemic levels. Although insulin resistance is the key pathophysiological mechanism, several surrogate biomarkers such as Homeostatic Model Assessment for Resistance (HOMA-IR), have been proposed. In recent years, research on triglyceride-glucose index useful marker identifying cardio-metabolic risk, particularly adults, rise. However, there paucity data role TyG children adolescents association with HOMA-IR DEXA (dual-energy X-ray absorptiometry), especially North America. Therefore, this study aims to investigate adolescents, explore relationship between American adolescents. Forty-four lean obese were recruited after obtaining informed consent, anthropometric laboratory assessments. was significantly higher than their counterparts (p < 0.001) correlated glucose, BMI, DEXA, triglycerides HOMA-IR. Thus, pilot shows that may serve an excellent assessing risk pediatrics.

Language: Английский

Citations

0
Associations of the triglyceride-glucose index with short-term mortality in patients with cardiogenic shock: a cohort study DOI Creative Commons
De-Gang Mo, Yanfeng Wang, Mengmeng Wang

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 4, 2025

Cardiogenic shock (CS) is a severe cardiac disorder with high mortality rate. The triglyceride-glucose (TyG) index, biomarker of insulin resistance, associated cardiovascular disease-related mortality. This study aimed to investigate the association between TyG index and in patients CS. retrospective cohort analyzed 727 CS from Medical Information Mart for Intensive Care IV database. was calculated as follows: ln[triglycerides (mg/dL) × fasting blood glucose (mg/dL)/2]. Outcomes included 28-day intensive care unit (ICU) in-hospital Kaplan-Meier survival curve models Cox proportional hazards regression were used evaluate prognostic significance index. Receiver Operating Characteristic (ROC) analysis determine predictive efficacy Subgroup analyses conducted across different groups. Non-survivors had significantly higher (ICU: 9.30 vs. 9.13, p = 0.008; in-hospital: 9.29 0.004). Adjusted showed that each 1-unit increase increased ICU risk by 24% (hazard ratio [HR] 1.24, 95% confidence interval [CI]:1.04-1.48; 0.015) 44% (HR 1.44, CI:1.11-1.88; 0.007). Quartile 4 77% 1.77, CI:1.09-2.89) compared 1 61% 1.61, CI:1.08-2.38). area under ROC (AUROC) modest standalone ability 0.56, but when combined clinical variables, AUROC improved 0.80 0.78 (in-hospital). identified stronger associations ≥ 60 years, females, non-septic, those acute myocardial infarction or heart failure. short-term may serve useful stratification. Not applicable.

Language: Английский

Citations

0
Circulating Neutrophil and Monocyte Ratios to High Density Lipoprotein-Cholesterol Are Elevated with Increased Triglyceride-Glucose Index DOI

Ishwarlal Jialal,

Beverley Adams‐Huet

Published: April 8, 2025

Original Research Articles Circulating Neutrophil and Monocyte Ratios to High Density Lipoprotein-Cholesterol Are Elevated with Increased Triglyceride-Glucose Index Ishwarlal Jialal 1,*,† Beverley Adams-Huet 2 1 UC Davis School of Medicine, 2616 Hepworth Drive, Davis, CA 95618, USA UT Southwestern Medical Center, Dallas, TX 75390, * Correspondence: [email protected]; Tel.: +1-530-902-0125 † Retired Distinguished Professor Internal Medicine Pathology. Received: 15 March 2025; Accepted: 28 Published: 8 April 2025 Abstract: The triglyceride-glucose (TyG) index, is a promising biomarker Metabolic Syndrome (MetS), Type-2 Diabetes (T2DM) premature atherosclerotic cardiovascular diseases (ASCVD). Whilst increased inflammation crucial mechanism in the pathogenesis these disorders there general paucity data on association TyG index inflammation. Accordingly, present report we investigated relationship between tertiles accepted measures inflammation, ratios (PMN):HDL-C Monocyte(Mono):HDL-C cohort 99 individuals (41 controls 58 patients MetS). Both PMN:HDL-C Mono:HDL-C significantly increasing both correlated index. Also was significant correlation certain biomarkers which also over Mono:HDL-C. In conclusion, this cross-sectional study, provide further support for pro-inflammatory phenotype an increase as manifest by increases ratio professional phagocytes (neutrophils monocytes) HDL-C, potential explain risk cardio-metabolic syndromes.

Language: Английский

Citations

0
Joint association of triglyceride glucose index (TyG) and body roundness index (BRI) with stroke incidence: a national cohort study DOI Creative Commons

Bingxue Wang,

Liying Li, Nelson L.S. Tang

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 16, 2025

Abstract Background Insulin resistance (IR), as quantified by the triglyceride glucose (TyG) index, and visceral obesity, assessed body roundness index (BRI), have been identified pivotal risk factors for stroke. However, combined impact of these two indicators on stroke has not thoroughly investigated. This study aims to investigate both separate associations, well potential interactions, between TyG and/or BRI with respect incidence. Methods cohort encompassed 6621 respondents who were free at baseline from China Health Retirement Longitudinal Study (CHARLS). Participants categorized based median values or/and BRI. Cox proportional hazards regression models employed examine associations alone, their effects Both additive multiplicative interaction further estimated. Results Among participants aged 45 years or older, mean (SD) age was 58.06 (8.57) years, 2951 (44.6%) being male. During a follow-up period up 9 743 individuals experienced events. Compared low BRI, adjusted hazard ratios (HRs) follows: 1.36 (95% confidence interval [CI] 1.05–1.75) high 1.61 CI 1.27–2.05) 1.78 1.40–2.26) Neither nor interactions incident statistically significant. The combination enhanced predictive capability compared either biomarker alone. Conclusion We discovered that are strongly associated joint assessment enhances stroke, underscoring critical role IR adiposity in identification screening risk. Graphical abstract

Language: Английский

Citations

0
The relationship between the triglyceride–glucose index and functional outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective cohort study DOI Creative Commons

Yuyang Hou,

Xinyi Guo,

Hongkuan Yang

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: May 9, 2025

Language: Английский

Citations

0
The predictive significance of the triglyceride-glucose index in forecasting adverse cardiovascular events among type 2 diabetes mellitus patients with co-existing hyperuricemia: a retrospective cohort study DOI Creative Commons

Jianyong Zhao,

Na Li, Shiqi Li

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: May 21, 2025

The triglyceride-glucose (TyG) index serves as a crucial indicator for evaluating insulin resistance (IR) and cardiovascular risk among patients with type 2 diabetes mellitus (T2DM). Concurrently, hyperuricemia (HUA) strongly correlates adverse outcomes. However, the prognostic value of TyG index, particularly in exhibiting both conditions, remains inadequately defined. This study assessed association between measurements incidence major events (MACEs) simultaneously diagnosed T2DM HUA. retrospective, single-center cohort included 628 HUA at Chaohu Hospital (Anhui Medical University) 2019 2024. Participants were stratified into tertiles based on their values. Kaplan-Meier survival curves log-rank tests estimated MACEs, Cox regression analyses calculated hazard ratios. additional predictive contribution was evaluated using C statistics, net reclassification improvement (NRI), integrated discrimination (IDI) metrics. During 38.00 ± 8.78 months follow-up period, 74 MACEs recorded. A significant proportional relationship emerged events-patients highest tertile demonstrated markedly increased compared those lowest (HR = 2.45, 95% CI 1.23-4.95). pivotal threshold identified > 8.40, beyond which each standard deviation increase corresponded to 66% higher probability 1.66, 1.36-2.36, P 0.014). Integrating traditional models significantly improved performance (C statistic increase: 0.64 → 0.67, 0.029; NRI 0.14, IDI 0.02, < 0.05). constitutes an autonomous MACE predictor specifically within distinctive manifesting is first validate 8.40 identify synergistic interaction serum uric acid (SUA) TyG, providing novel stratification tool managing dual metabolic disorders.

Language: Английский

Citations

0
The predictive value of triglyceride‐glucose index, lipid accumulation product and lipid ratio on metabolic syndrome in polycystic ovary syndrome patients DOI
Ning Ma,

Xiaoning Cui,

Na Wang

et al.

Journal of Obstetrics and Gynaecology Research, Journal Year: 2025, Volume and Issue: 51(4)

Published: April 1, 2025

Abstract Objectives To identify reliable indicators to predict the occurrence of metabolic syndrome (MetS) and provide an effective way prevent it in polycystic ovary (PCOS), we explored relationships between triglyceride‐glucose index (Ty‐G), lipid accumulation product (LAP), ratio, MetS. Methods We detected relationship Ty‐G index, LAP, incidence In addition, classified LAP into tertiles determine efficacy these predicting risk Finally, effects ratio on prediction MetS were evaluated with receiver operating characteristic (ROC) curve. Results Our results indicate that was 38% 134 patients PCOS, independent factors for significantly increased LAP. The ROC curve showed all good performance PCOS patients, but had highest predictive value, a cut‐off value 8.70. Conclusions study revealed plays important role patients. monitoring blood glucose levels is approach preventing clinically regardless age, weight management should be strictly implemented overweight obese

Language: Английский

Citations

0
Apolipoprotein B and Glycemic Dysregulation: New Predictors of Type 2 Diabetes in High-Cardiovascular-Risk Populations DOI Open Access
Makhabbat Bekbossynova, T Ivanova-Razumova,

Aknur Kali

et al.

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(5), P. 163 - 163

Published: April 23, 2025

Background: Apolipoprotein B (ApoB), a key component of atherogenic lipoproteins, has been increasingly implicated in cardiometabolic disorders beyond dyslipidemia. However, its role glycemic dysregulation remains unclear. This study aimed to investigate the association between ApoB levels and parameters, including fasting glucose, insulin resistance, glycated hemoglobin (HbA1c), individuals without diagnosed diabetes. Methods: was conducted at National Research Cardiac Surgery Center (Kazakhstan) over period 2023 2024 as cross-sectional analysis. Adults aged ≥ 20 years diabetes with complete data on their markers were included. Associations plasma glucose (FPG), HbA1c, HOMA-IR assessed using multivariable linear logistic regression models adjusted for demographic, lifestyle, metabolic covariates. Results: Higher significantly associated increased (β = 2.07 mg/dL per 1-SD increase ApoB, p < 0.001), higher HbA1c 0.06%, elevated 0.54, 0.001). Participants highest quartile had 53% odds prediabetes (adjusted OR 1.53; 95% CI: 1.22-1.91; 0.001) compared lowest quartile. These associations remained significant after adjusting BMI, lipid levels, other confounders. Conclusions: Elevated is independently adverse profiles nondiabetic individuals, suggesting potential early metabolism disturbances.

Language: Английский

Citations

0
The predictive significance of the triglyceride-glucose index in forecasting adverse cardiovascular events among type 2 diabetes mellitus patients with co-existing hyperuricemia: a retrospective cohort study DOI
J Zhao, Na Li, Shiqi Li

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Background The triglyceride-glucose (TyG) index functions as a crucial parameter for assessing insulin resistance (IR) and cardiovascular vulnerability among type 2 diabetes mellitus (T2DM) patients. Concurrently, hyperuricemia (HUA) demonstrates robust correlations with unfavorable outcomes. Nevertheless, the prognostic capability of TyG particularly within populations exhibiting both conditions remains inadequately defined. This investigation examined relationship between measurements incidence major adverse events (MACEs) in subjects simultaneously diagnosed T2DM HUA. Methods retrospective cohort analysis from single institution incorporated 628 patients HUA at Chaohu Hospital (Anhui Medical University) 2019–2024. Participants were stratified into tertiles according to their values. MACE probability was evaluated through Kaplan-Meier curves log-rank comparisons, while hazard ratios calculated using Cox regression analyses. supplementary predictive contribution quantified via C statistics, net reclassification improvement (NRI), integrated discrimination (IDI) parameters. Results Throughout 38.00 ± 8.78 month surveillance interval, 74 MACEs documented. A distinct proportional association emerged incidents—subjects uppermost tertile experienced markedly elevated risk compared those lowest category (HR = 2.45, 95%CI 1.23–4.95). pivotal demarcation point identified > 8.40, beyond which each standard deviation increment corresponded 66% heightened 1.66, 1.36–2.36, P 0.014). Incorporation traditional frameworks considerably enhanced efficacy across multiple statistical indicators (C statistic enhancement: 0.64→0.67, 0.029; NRI 0.14, IDI 0.02, < 0.05). Conclusion constitutes an autonomous predictor specifically distinctive manifesting Systematic evaluation this biomarker could enhance classification therapeutic approaches these susceptible individuals.

Language: Английский

Citations

0