Gallstones in the Era of Metabolic Syndrome: Pathophysiology, Risk Prediction, and Management

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Gallstone disease (GSD) and metabolic syndrome (MetS) are increasingly prevalent conditions with significant global health implications. Recent evidence highlights a strong epidemiological association between these disorders, driven by shared pathophysiological mechanisms. This review provides comprehensive analysis of the intricate relationship MetS GSD, focusing on role insulin resistance, dyslipidemia, obesity, gut microbiota dysbiosis in gallstone formation. An integrated model is proposed, linking disturbances to bile cholesterol supersaturation, gallbladder dysmotility, chronic inflammation. The also explores clinical implications, including risk prediction models based parameters, early detection biomarkers, targeted interventions such as lifestyle modifications, pharmacological therapies, microbiome modulation. By addressing underpinnings this synthesis offers foundation for developing preventive therapeutic strategies mitigate burden interconnected conditions. Future research directions outlined refine mechanistic insights improve outcomes.

Language: Английский

The relationship between body roundness index (BRI) and suicidal ideation: Evidence from NHANES 2013-2018

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Importance: Emerging research suggests a complex interplay between physical health metrics and mental outcomes, including suicidal ideation. The body roundness index (BRI), novel measure of size, may offer insights into this relationship. This study seeks to investigate the intricate connection BRI ideation in sample that reflects entire U.S. population-working validate potential as predictor Methods: Data from NHANES spanning 2013 2018 was used cross-sectional analyze 14,058 participants. calculated based on height waist circumference measurements. Suicidal assessed using Mental Health-Depression Screener Questionnaire ninth question. To non-linear relationships ideation, we employed generalized additive models smooth curve fitting, ROC curves compare predictive ability BMI for Subgroup analyses interaction tests were utilized moderating effects categorical covariates. Results: Multiple logistic regression analysis revealed significant positive correlation increased heightened with nonlinear pattern persisting even after adjustment relationship reinforced by sharp increase prevalence when exceeded 6.7. Based analysis, demonstrates slightly stronger suicide compared BMI. confirmed relative robustness association across populations, age, education PRI, etc. However, two influenced gender, coronary artery disease angina pectoris. Conclusion: In conclusion, our reveals exceeds It is recommended appropriate be maintained minimize

Language: Английский

The relationship between body roundness index (BRI) and suicidal ideation: evidence from NHANES 2013–2018

BMC Psychiatry, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 17, 2025

Language: Английский