Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(11), P. 4391 - 4416
Published: May 20, 2023
Owing
to
the
inherent
shortcomings
of
traditional
therapeutic
drugs
in
terms
inadequate
efficacy
and
toxicity
clinical
treatment,
nanomedicine
designs
have
received
widespread
attention
with
significantly
improved
reduced
non-target
side
effects.
Nanomedicines
hold
tremendous
theranostic
potential
for
treating,
monitoring,
diagnosing,
controlling
various
diseases
are
attracting
an
unfathomable
amount
input
research
resources.
Against
backdrop
exponentially
growing
number
publications,
it
is
imperative
help
audience
get
a
panorama
image
activities
field
nanomedicines.
Herein,
this
review
elaborates
on
development
trends
nanomedicines,
emerging
nanocarriers,
vivo
fate
safety
their
extensive
applications.
Moreover,
challenges
obstacles
hindering
translation
nanomedicines
also
discussed.
The
elaboration
aspects
may
enlighten
readers
set
route
future
endeavors.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(6), P. 1213 - 1213
Published: June 7, 2022
Colorectal
cancer
(CRC)
is
a
global
health
problem
responsible
for
10%
of
all
incidences
and
9.4%
deaths
worldwide.
The
number
new
cases
increases
per
annum,
whereas
the
lack
effective
therapies
highlights
need
novel
therapeutic
approaches.
Conventional
treatment
methods,
such
as
surgery,
chemotherapy
radiotherapy,
are
widely
applied
in
oncology
practice.
Their
success
little,
therefore,
search
technologies
ongoing.
Many
efforts
have
focused
recently
on
development
safe
efficient
nanomedicines.
Nanoparticles
among
them.
They
uniquewith
their
properties
nanoscale
hold
potential
to
exploit
intrinsic
metabolic
differences
between
healthy
cells.
This
feature
allows
them
induce
high
levels
toxicity
cells
with
little
damage
surrounding
tissues.
Graphene
oxide
promising
2D
material
found
play
an
important
role
treatments
through
several
strategies:
direct
killing
chemosensitization,
drug
gene
delivery,
phototherapy.
Several
approaches
based
nanoparticles,
particularly
graphene
oxide,
currently
under
research
clinical
trials,
some
already
been
approved.
Here,
we
provide
update
recent
advances
nanomaterials-based
CRC-targeted
therapy,
special
attention
nanomaterials.
We
summarise
epidemiology,
carcinogenesis,
stages
CRCs,
current
its
treatment.
Polymers,
Journal Year:
2022,
Volume and Issue:
14(4), P. 687 - 687
Published: Feb. 11, 2022
Reactive
oxygen
species
(ROS)-sensitive
drug
delivery
systems
(DDS)
specifically
responding
to
altered
levels
of
ROS
in
the
pathological
microenvironment
have
emerged
as
an
effective
means
enhance
pharmaceutical
efficacy
conventional
nanomedicines,
while
simultaneously
reducing
side
effects.
In
particular,
use
biocompatible,
biodegradable,
and
non-toxic
ROS-responsive
thioketal
(TK)
functional
group
design
smart
DDS
has
grown
exponentially
recent
years.
TK-based
DDS,
different
technological
uses
TK
been
proposed
overcome
major
limitations
counterparts
including
uncontrolled
release
off-target
This
review
will
focus
on
biomaterials
nanomedicines
by
using
it
a
linker
connect
surface
nanoparticles,
form
prodrugs,
core
component
directly
control
its
structure,
opening
drug-releasing
gates
or
change
conformation
nano-systems.
A
comprehensive
view
various
may
allow
researchers
exploit
this
reactive
more
consciously
designing
be
with
improved
disease-targeting
ability,
providing
novel
therapeutic
opportunities
treatment
many
diseases.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 5, 2023
Given
the
emergence
of
resistant
bacterial
strains
and
novel
microorganisms
that
globally
threaten
human
life,
moving
toward
new
treatment
modalities
for
microbial
infections
has
become
a
priority
more
than
ever.
Antimicrobial
photodynamic
therapy
(aPDT)
been
introduced
as
promising
non-invasive
local
adjuvant
in
several
oral
infectious
diseases.
Its
efficacy
elimination
bacterial,
fungal,
viral
key
pathogens
such
Streptococcus
mutans,
Porphyromonas
gingivalis,
Candida
albicans,
Enterococcus
faecalis
have
investigated
by
many
invitro
clinical
studies.
Researchers
also
methods
increasing
amazing
developments
production
natural,
nano
based,
targeted
photosensitizers.
As
studies
an
important
role
paving
way
towards
evidence-based
applications
infection
this
method,
current
review
aimed
to
provide
overall
view
potential
field
summarize
data
available
randomized
controlled
conducted
on
aPDT
dentistry
investigate
its
future
horizons
dental
practice.
Four
databases
including
PubMed
(Medline),
Web
Science,
Scopus
Embase
were
searched
up
September
2022
retrieve
related
There
are
reporting
effective
adjunctive
modality
capable
reducing
pathogenic
loads
periodontal
peri-implant,
persistent
endodontic
infections.
Clinical
evidence
reveals
therapeutic
prevention
reduction
cariogenic
organisms
with
fungal
or
origins,
however,
number
these
groups
much
less.
Altogether,
various
photosensitizers
used
it
is
still
not
possible
recommend
specific
irradiation
parameters
due
heterogenicity
among
Reaching
protocols
difficult
requires
further
high
quality
trials
focusing
PS
shown
able
reduce
sufficient
follow-up
periods.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(13), P. 4488 - 4514
Published: Jan. 1, 2023
One-dimensional
(1-D)
nanomaterials
possess
unique
shape-dependent
phyicochemical
properties
and
are
increasingly
recognized
as
promising
materials
for
nanotechnology.
1-D
can
be
classified
according
to
their
shape,
such
nanorods,
nanotubes,
nanowires,
self-assembled
nanochains,
etc.,
have
been
applied
in
electronics,
photonics,
catalysis.
The
biological
characteristics
of
nanomaterials,
including
high
drug
loading
efficiency,
prolonged
blood
circulation,
the
ability
capture
cancer
cells,
cellular
uptake
mechanisms,
efficient
photothermal
conversion,
material
tunability,
aided
extending
potential
biomedical
applications,
particularly
therapy
diagnosis.
This
review
highlights
a
novel
perspective
on
emerging
diagnosis
by
introducing
definition
physicochemical
properties,
recent
advances
also
proposes
unexplored
nanomaterial
types
therapeutic
applications
nanomaterials.
In
particular,
most
significant
exciting
years,
ultrasound-enabled
sonodynamic
therapy,
magnetic
field-based
bioresponsive
intracellular
self-assembly
situ,
discussed
along
with
concepts,
piezoelectric
nanozyme-based
nanomedicine,
others.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(29)
Published: June 9, 2023
Abstract
Growing
concern
about
photothermal
tumor
therapy
(PTT)
as
a
promising
alternative
to
conventional
liver
cancer
treatment,
which
is
treatment
strategy
that
utilizes
near‐infrared
(NIR)
light‐induced
agents
(PTAs)
yield
effects
localize
thermal
damage
for
tumors.
Herein,
given
the
gap
between
experimental
research
and
clinical
application,
this
review
seeks
timely
summarize
highlight
recent
progress
of
PTAs
used
in
vivo
vitro
last
five‐year.
The
implications
various
on
multifunctional
conversion
capability,
structure‐performance
correlations
PTT,
together
with
evaluation
their
potential
application
are
systematically
dissected
further
dig
out
what
buried
mechanism
is.
Besides,
higher
requirements
put
forward
discrepancies
crucial
issues
faced
by
different
PTT
related
medical
technical
obstacles
being
conquered,
lays
solid
theoretical
foundation
field
oncology
whole,
especially
cancer.
Finally,
it
expected
can
present
valuable
guidance
design
efficient,
photostability,
biosafety‐aware
anticancer
while
stepping
into
fast
traffic
lane
from
bench
bedside
foreseeable
future.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: June 20, 2023
Abstract
Untethered
magnetic
miniature
soft
robots
capable
of
accessing
hard-to-reach
regions
can
enable
safe,
disruptive,
and
minimally
invasive
medical
procedures.
However,
the
body
limits
integration
non-magnetic
external
stimuli
sources
on
robot,
thereby
restricting
functionalities
such
robots.
One
functionality
is
localised
heat
generation,
which
requires
solid
metallic
materials
for
increased
efficiency.
Yet,
using
these
compromises
compliance
safety
To
overcome
competing
requirements,
we
propose
a
pangolin-inspired
bi-layered
robot
design.
We
show
that
reported
design
achieves
heating
>
70
°C
at
large
distances
5
cm
within
short
period
time
<30
s,
allowing
users
to
realise
on-demand
in
tandem
with
shape-morphing
capabilities.
demonstrate
advanced
robotic
functionalities,
as
selective
cargo
release,
situ
demagnetisation,
hyperthermia
mitigation
bleeding,
tissue
phantoms
ex
vivo
tissues.
Cells,
Journal Year:
2023,
Volume and Issue:
12(17), P. 2147 - 2147
Published: Aug. 25, 2023
In
the
emerging
era
of
cancer
immunotherapy,
immune
checkpoint
blockades
(ICBs)
and
adoptive
cell
transfer
therapies
(ACTs)
have
gained
significant
attention.
However,
their
therapeutic
efficacies
are
limited
due
to
presence
cold
type
tumors,
immunosuppressive
tumor
microenvironment,
immune-related
side
effects.
On
other
hand,
dendritic
(DC)-based
vaccines
been
suggested
as
a
new
immunotherapy
regimen
that
can
address
limitations
encountered
by
ICBs
ACTs.
Despite
success
first
generation
DC-based
vaccines,
represented
FDA-approved
vaccine
Provenge,
several
challenges
remain
unsolved.
Therefore,
DC
strategies
actively
investigated.
This
review
addresses
currently
most
adopted
classical
evaluates
generations
in
detail,
including
biomaterial-based,
immunogenic
death-inducing,
mRNA-pulsed,
small
extracellular
vesicle
(sEV)-based,
sEV-based
vaccines.
These
innovative
envisioned
provide
breakthrough
landscape
expected
be
supported
further
preclinical
clinical
studies.
