Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 300, P. 120226 - 120226
Published: Oct. 14, 2022
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129537 - 129537
Published: Jan. 25, 2024
Language: Английский
Citations
22
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 1 - 30
Published: April 23, 2024
Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.
Language: Английский
Citations
22
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 265 - 282
Published: Jan. 29, 2024
Language: Английский
Citations
21
International Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: 55(3)
Published: Jan. 8, 2025
Exosomes are integral to the pathophysiology of osteoarthritis (OA) due their roles in mediating intercellular communication and regulating inflammatory processes. transport bioactive molecules, such as proteins, lipids nucleic acids, which can influence chondrocyte behavior joint homeostasis. Given properties regeneration ability target damaged tissues, exosomes represent a promising therapeutic avenue for OA treatment. have potential promoting cartilage repair, reducing inflammation improving overall function. However, several challenges remain, including need standardized isolation characterization methods, variability exosomal content, regulatory hurdles. The present review aims provide comprehensive overview current understanding exosome mechanisms potential, while also addressing ongoing faced translating these findings into clinical practice. By consolidating existing research, pave way future studies aimed at optimizing exosome‑based therapies effective management.
Language: Английский
Citations
2
Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123248 - 123248
Published: Jan. 13, 2025
Language: Английский
Citations
2
Bioactive Materials, Journal Year: 2022, Volume and Issue: 22, P. 423 - 452
Published: Oct. 20, 2022
Osteoarthritis (OA) is a highly prevalent whole-joint disease that causes disability and pain affects patient's quality of life. However, currently, there lack effective early diagnosis treatment. Although stem cells can promote cartilage repair treat OA, problems such as immune rejection tumorigenicity persist. Extracellular vesicles (EVs) transmit genetic information from donor mediate intercellular communication, which considered functional paracrine factor cells. Increasing evidences suggest EVs may play an essential complex role in the pathogenesis, diagnosis, treatment OA. Here, we introduced OA progression by influencing inflammation, metabolism, aging. Next, discussed blood, synovial fluid, joint-related for diagnosis. Moreover, outlined potential modified unmodified their combination with biomaterials therapy. Finally, discuss deficiencies put forward prospects challenges related to application field
Language: Английский
Citations
63
Gels, Journal Year: 2022, Volume and Issue: 8(6), P. 328 - 328
Published: May 24, 2022
Hydrogels, which are hydrophilic polymer networks, have attracted great attention, and significant advances in their biological biomedical applications, such as for drug delivery, tissue engineering, models medical studies, been made. Due to similarity physiological structure, hydrogels highly compatible with extracellular matrices tissues can be used both carriers encapsulate cellular secretions. As small vesicles secreted by nearly all mammalian cells mediate cell–cell interactions, exosomes play very important roles therapeutic approaches disease diagnosis. To maintain activity achieve controlled release, a strategy that embeds composite system has focused on recent studies. Therefore, this review aims provide thorough overview of the use embedding including resources making properties hydrogels, strategies combination exosomes.
Language: Английский
Citations
49
Materials Today Bio, Journal Year: 2022, Volume and Issue: 18, P. 100512 - 100512
Published: Dec. 5, 2022
Mitochondrial dysfunction causes the production of reactive oxygen species (ROS) and oxidative damage, stress inflammation are considered key factors causing intervertebral disc degeneration (IVDD). Thus, restoring mitochondrial is an attractive strategy for treating IVDD. Platelet-derived extracellular vesicles (PEVs) nanoparticles that target inflammation. Moreover, produced by platelets (PLTs) have considerable anti-inflammatory effects. We investigate use PEVs as a therapeutic IVDD in this study. extract evaluate their properties; test effects on H2O2-induced damage nucleus pulposus (NP) cells; verify role repairing cellular dysfunction; demonstrate rat model. The results confirm can restore impaired function, reduce stress, cell metabolism regulating sirtuin 1 (SIRT1)-peroxisome proliferator-activated receptor gamma coactivator 1α (PGC1α)-mitochondrial transcription factor A (TFAM) pathway; models, retard progression Our injection be promising patients with
Language: Английский
Citations
44
Burns & Trauma, Journal Year: 2023, Volume and Issue: 11
Published: Jan. 1, 2023
Abstract Background Sphingosine-1-phosphate (S1P), a key regulator of vascular homeostasis and angiogenesis, is enriched in exosomes derived from platelet-rich plasma (PRP-Exos). However, the potential role PRP-Exos-S1P diabetic wound healing remains unclear. In this study, we investigated underlying mechanism angiogenesis repair. Methods Exosomes were isolated PRP by ultracentrifugation analysed transmission electron microscopy, nanoparticle tracking analysis western blotting. The concentration S1P PRP-Exos was measured enzyme-linked immunosorbent assay. expression level receptor1–3 (S1PR1–3) skin Q-PCR. Bioinformatics proteomic sequencing conducted to explore possible signalling pathway mediated PRP-Exos-S1P. A mouse model used evaluate effect on healing. Immunofluorescence for cluster differentiation 31 (CD31) assess model. Results vitro, significantly promoted cell proliferation, migration tube formation. Furthermore, accelerated process closure vivo. present at high level, S1PR1 elevated compared with S1PR2 S1PR3 patients animals. formation not human umbilical vein endothelial cells treated shS1PR1. model, inhibition wounding sites decreased new blood vessels delayed closure. proteomics indicated that fibronectin 1 (FN1) closely related due its colocalization skin. Further study supported FN1 plays an important PRP-Exos-S1P-mediated S1PR1/protein kinase B pathway. Conclusions promotes via B/FN1 Our findings provide preliminary theoretical foundation treatment foot ulcers using future.
Language: Английский
Citations
43
Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 159, P. 111 - 127
Published: Feb. 1, 2023
Language: Английский
Citations
35