Monocyte/Macrophage‐Mediated Transport of Dual‐Drug ZIF Nanoplatforms Synergized with Programmed Cell Death Protein‐1 Inhibitor Against Microsatellite‐Stable Colorectal Cancer

Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)

Published: Aug. 5, 2024

Microsatellite-stable colorectal cancer (MSS-CRC) exhibits resistance to programmed cell death protein-1 (PD-1) therapy. Improving the infiltration and tumor recognition of cytotoxic T-lymphocytes (CTLs) is a promising strategy, but it encounters huge challenges from drug delivery mechanisms aspects. Here, zeolitic imidazolate framework (ZIF) coated with apoptotic body membranes derived MSS-CRC cells engineered for co-delivery ginsenoside Rg1 (Rg1) atractylenolide-I (Att) MSS-CRC, named as Ab@Rg1/Att-ZIF. This system selectively engulfed by Ly-6C

Language: Английский

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Chitosan-based hydrogels in cancer therapy: Drug and gene delivery, stimuli-responsive carriers, phototherapy and immunotherapy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137047 - 137047

Published: Nov. 1, 2024

Language: Английский

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Nanoparticles for imaging-guided photothermal therapy of colorectal cancer

Heliyon, Journal Year: 2023, Volume and Issue: 9(11), P. e21334 - e21334

Published: Oct. 20, 2023

Colorectal cancer (CRC) is one of the most common malignancies with a high mortality rate worldwide. While surgery, chemotherapy, and radiotherapy have shown some effectiveness in improving survival rates, they come drawbacks such as side effects harm to healthy tissues. The theranostic approach, which integrates processes diagnosis treatment, can minimize biological effects. Photothermal therapy (PTT) an emerging treatment method that usages light-sensitive agents generate heat at tumor site induce thermal erosion. development nanotechnology for CRC using imaging-guided PTT has garnered significant. Nanoparticles suitable physical chemical properties enhance efficiency PTT. This approach enables monitoring progress safeguards In this article, we concisely introduce application metal nanoparticles, polymeric carbon nanoparticles colorectal cancer.

Language: Английский

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Drug repurposing-based nanoplatform via modulating autophagy to enhance chemo-phototherapy against colorectal cancer

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 24, 2024

Abstract Multi-modal combination therapy is regarded as a promising approach to cancer treatment. Combining chemotherapy and phototherapy an essential multi-modal endeavor. Ivermectin (IVM) potent antiparasitic agent identified having potential antitumor properties. However, the fact that it induces protective autophagy while killing tumor cells poses challenge its further application. IR780 iodide (IR780) near-infrared (NIR) dye with outstanding photothermal (PTT) photodynamic (PDT) effects. hydrophobicity, instability, low uptake of limit clinical applications. Here, we have structurally modified hydroxychloroquine, inhibitor, synthesize novel compound H780. H780 IVM can form H780-IVM nanoparticles (H-I NPs) via self-assembly. Using hyaluronic acid (HA) modify H-I NPs, nano-delivery system HA/H780-IVM (HA/H-I was synthesized for chemotherapy-phototherapy colorectal (CRC). Under NIR laser irradiation, HA/H-I NPs effectively overcame limitations exhibited cytotoxicity. In vitro in vivo experiment results showed excellent anti-CRC Therefore, our study provides strategy CRC treatment could enhance chemo-phototherapy by modulating autophagy.

Language: Английский

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Thermo-responsive composite nanoparticles based on hydroxybutyl chitosan oligosaccharide: Fabrication, stimulus release and cancer therapy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133842 - 133842

Published: July 14, 2024

Language: Английский

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miRNA-sequencing and bioinformatics analyses of key miRNAs and their associated genes regulated by EC-synthetic retinoids treatment in Caco-2 cancer cells

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102145 - 102145

Published: Jan. 1, 2025

Language: Английский

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Uncovering the underlying mechanism of yuanhuacine against colorectal cancer by transcriptomics and experimental investigations

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156570 - 156570

Published: Feb. 25, 2025

Language: Английский

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NAD+/SIRT1 pathway regulates glycolysis to promote oxaliplatin resistance in colorectal cancer

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(11)

Published: March 12, 2025

BACKGROUND Glycolysis provides growth advantages and leads to drug resistance in colorectal cancer (CRC) cells. SIRT1, an NAD+-dependent deacetylase, regulates various cellular processes, its upregulation results antitumor effects. This study investigated the role of SIRT1 metabolic reprogramming oxaliplatin CRC AIM To investigate overcoming METHODS We performed transcriptome sequencing human parental cells oxaliplatin-resistant identify differentially expressed genes. Key regulators were identified via LINCS database. NAD+ levels measured by flow cytometry, effects on sensitivity assessed MTS assays, colony formation xenograft models. Glycolytic function was using Western blot Seahorse assays. RESULTS Salermide, a inhibitor, as candidate compound that enhances resistance. In cells, downregulated, whereas γH2AX PARP upregulated. activation led depletion inhibition, which reversed inhibitor treatment. The increase expression overcame resistance, while inhibition increased glycolysis, inhibited glycolysis resistant characterized reduced glycolytic enzymes PKM2 LDHA, well decreased extracellular acidification rate. shikonin induced inhibition. CONCLUSION is due activation, turn increases glycolysis. Restoring reverses offering promising therapeutic strategy overcome

Language: Английский

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Nanocarriers in inflammatory bowel disease and colorectal cancer

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 657 - 687

Published: Jan. 1, 2025

Language: Английский

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Fabrication of curcumin-loaded magnetic PEGylated-PLGA nanocarriers tagged with GRGDS peptide for improving anticancer activity

MethodsX, Journal Year: 2023, Volume and Issue: 10, P. 102229 - 102229

Published: Jan. 1, 2023

Carrier-mediated drug delivery systems are highly promising as a treatment option for the targeted of potent cytotoxic drugs with increased efficacy and safety. Considering that poly (lactic-co-glycolic acid) (PLGA) polyethylene glycol (PEG) polymers each provide certain advantages biological purposes, PEGylated-PLGA nanoparticles have emerged leading candidate among other alternatives. Furthermore, these can be modified specific short peptide sequences such glycine-arginine-glycine-aspartic acid‑serine (GRGDS), which selectively binds to integrins overexpressed in most cancer cells, allowing delivery. Here, we reported details fabrication characterization magnetic functionalized GRGDS peptide. In addition, superparamagnetic iron oxide (SPIONs) natural pharmaceutical compound curcumin (Cur) were loaded into polymeric assess their anticancer activity potential. Overall, this study provides comprehensive methodologies, including all synthesis procedures, challenges, useful suggestions peptide-conjugated may used cellular targeting therapeutic applications.•Step by step protocol Cur was presented.•Validation conjugation shown via detailed studies.•The effect Cur-loaded GRGDS-tagged tested on T98G glioblastoma cell line preliminary vitro study.

Language: Английский

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