Green-synthesized Metal Nanoparticles for Cancer Diagnosis and Treatment: A Critical Review DOI
Ravindra Waykar,

Srinivasakumar Kumarapillai,

Yogesh A. Kulkarni

et al.

Nanoscience &amp Nanotechnology-Asia, Journal Year: 2024, Volume and Issue: 14(4)

Published: Aug. 1, 2024

: The utilization of chemotherapy remains an established therapeutic strategy in the ongoing fight against cancer. Nevertheless, it has been impeded by occurrence several fatal adverse reactions caused non-specific toxicity often associated with chemotherapy. Nanotechnology is emerging field research that experiencing rapid growth and widely recognized as a highly promising approach for advanced cancer therapy. Biosynthesized green nanomaterials are tools treatment diagnosis. Metal nanoparticles have developed use applications, including magnetically sensitive medication delivery, photothermal treatment, photoimaging. Nanomaterials containing metals, such iron, cobalt, silver, which generated from various bio-sources, described. boundless capabilities already had profound impact on human existence. potential effects health consistently instilled apprehension. A thorough investigation intricate nature facilitated emergence nanotoxicology, examines fundamental origins these problems. introduction chemistry principles aimed to provide safer techniques production management nanomaterials, resulting nanotechnology. This review article highlights uses nanotechnology detection tumors, challenges they face reaching clinical trials.

Language: Английский

Approved Nanomedicine against Diseases DOI Creative Commons

Yuanchao Jia,

Yuxin Jiang,

Yonglong He

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 774 - 774

Published: Feb. 26, 2023

Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases. Nanotechnology represents one the most effective approaches in elevating drug‘s treatment efficacy reducing toxicity by improving drug solubility, altering biodistribution, controlling release. The development materials has brought profound revolution medicine, significantly affecting various major diseases such as cancer, injection, cardiovascular experienced explosive growth past few years. Although clinical transition nanomedicine not very satisfactory, traditional drugs still occupy dominant position formulation development, but increasingly active have adopted nanoscale forms limit side effects improve efficacy. review summarized approved nanomedicine, its indications, properties commonly used nanocarriers nanotechnology.

Language: Английский

Citations

59
Recent trends in preparation and biomedical applications of iron oxide nanoparticles DOI Creative Commons

Yu Qing Meng,

Ya Nan Shi,

Yong Zhu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 8, 2024

Abstract The iron oxide nanoparticles (IONPs), possessing both magnetic behavior and semiconductor property, have been extensively used in multifunctional biomedical fields due to their biocompatible, biodegradable low toxicity, such as anticancer, antibacterial, cell labelling activities. Nevertheless, there are few IONPs clinical use at present. Some approved for withdrawn insufficient understanding of its applications. Therefore, a systematic summary IONPs’ preparation applications is crucial the next step entering practice from experimental stage. This review summarized existing research past decade on biological interaction with animal/cells models, human. aims provide cutting-edge knowledge involved effects vivo vitro, improve smarter design application clinic trials. Graphical

Language: Английский

Citations

51
Iron Oxide Nanoparticle-Based Ferro-Nanofluids for Advanced Technological Applications DOI Creative Commons
Mohd Imran, Anis Ahmad Chaudhary, Shahzad Ahmed

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(22), P. 7931 - 7931

Published: Nov. 16, 2022

Iron oxide nanoparticle (ION)-based ferro-nanofluids (FNs) have been used for different technological applications owing to their excellent magneto-rheological properties. A comprehensive overview of the current advancement FNs based on IONs various engineering is unquestionably necessary. Hence, in this review article, important advanced ION-based concerning fields are critically summarized. The chemical mainly focused mass transfer processes. Similarly, electrical and electronics magnetic field sensors, FN-based temperature sensors tilt microelectromechanical systems (MEMS) on-chip components, actuators, cooling electronic devices photovoltaic thermal systems. On other hand, environmental encompass water air purification. Moreover, mechanical or include dampers sealings. This article provides up-to-date information related advancements emerging trends FN research fields, as well discusses challenges future perspectives.

Language: Английский

Citations

40
Atmospheric microplastic and nanoplastic: The toxicological paradigm on the cellular system DOI Creative Commons
Anmol Choudhury, Faizan Zarreen Simnani, Dibyangshee Singh

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 259, P. 115018 - 115018

Published: May 20, 2023

The increasing demand for plastic in our daily lives has led to global pollution. improper disposal of resulted a massive amount atmospheric microplastics (MPs), which further the production nanoplastics (NPs). Because its intimate relationship with environment and human health, microplastic nanoplastic contamination is becoming problem. are microscopic light, they may penetrate deep into lungs. Despite several studies demonstrating abundance air, potential risks remain unknown. small size, characterization presented significant challenges. This paper describes sampling procedures nanoplastics. study also examines numerous harmful effects particles on health other species. There void research toxicity airborne upon inhalation, toxicological future. Further needed determine influence pulmonary diseases.

Language: Английский

Citations

38
Recent Advances in Nanotherapeutics for Neurological Disorders DOI Creative Commons
Arti Vashist, Pandiaraj Manickam, Andrea Raymond

et al.

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(7), P. 2614 - 2621

Published: June 27, 2023

Neurological disorders remain a significant health and economic burden worldwide. Addressing the challenges imposed by existing drugs, associated side- effects, immune responses in neurodegenerative diseases is essential for developing better therapies. The activation diseased state has complex treatment protocols results hurdles clinical translation. There an immense need development of multifunctional nanotherapeutics with various properties to address different limitations interactions exhibited therapeutics. Nanotechnology proven its potential improve therapeutic delivery enhance efficacy. Promising advancements have been made nanotherapies that can be combined CRISPR/Cas9 or siRNA targeted approach unique Engineering natural exosomes derived from mesenchymal stem cells (MSCs), dendritic (DCs), macrophages both deliver therapeutics modulate tumors disease (ND) allow personalized approaches. In present review, we summarize overview recent advances addressing neuroimmune ND therapies provide insights into upcoming nanotechnology-based nanocarriers.

Language: Английский

Citations

27
Nucleic acid drugs: recent progress and future perspectives DOI Creative Commons

Xiaoyi Sun,

Sarra Setrerrahmane,

Chencheng Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Nov. 29, 2024

Language: Английский

Citations

13
Advancements in magnetic nanoparticle-based biosensors for point-of-care testing DOI
Miaomiao Wang, Lian Jin, Polly H. M. Leung

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 25, 2024

The significance of point-of-care testing (POCT) in early clinical diagnosis and personalized patient care is increasingly recognized as a crucial tool reducing disease outbreaks improving survival rates. Within the realm POCT, biosensors utilizing magnetic nanoparticles (MNPs) have emerged subject substantial interest. This review aims to provide comprehensive evaluation current landscape emphasizing its growing within practice. Subsequently, status combination MNPs Biological detection has been presented. Furthermore, it delves into specific domain MNP-based biosensors, assessing their potential impact on POCT. By combining existing research spotlighting pivotal discoveries, this enhances our comprehension advancements promising prospects offered by context It seeks facilitate informed decision-making among healthcare professionals researchers while also promoting further exploration field study.

Language: Английский

Citations

12
Strategies Employed to Design Biocompatible Metal Nanoparticles for Medical Science and Biotechnology Applications DOI
Mariana Bortholazzi Almeida,

Caio Menezes Ribeiro Galdiano,

F Benvenuto

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

The applicability of nanomaterials has evolved in biomedical domains thanks to advances biocompatibility strategies and the mitigation cytotoxic effects, allowing diagnostics, imaging, therapeutic approaches. application nanoparticles (NP), particularly metal (mNPs), such as gold (Au) silver (Ag), includes inherent challenges related material characteristics, surface modification, bioconjugation techniques. By tailoring properties through appropriate coating with biocompatible molecules or functionalization active biomolecules, researchers can reach a harmonious interaction biological systems samples (mostly fluids tissues). Thus, this review highlights mechanisms associated obtention mNP presents comprehensive overview methods that facilitate safe efficient production. Therefore, we consider be valuable resource for all navigating dynamic field.

Language: Английский

Citations

7
Advancements in stimulation therapies for peripheral nerve regeneration DOI
Rosalie Bordett,

Khadija Basiru Danazumi,

Suranji Wijekoon

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(5), P. 052008 - 052008

Published: Aug. 22, 2024

Abstract Soft-tissue injuries affecting muscles, nerves, vasculature, tendons, and ligaments often diminish the quality of life due to pain, loss function, financial burdens. Both natural healing surgical interventions can result in scarring, which potentially may impede functional recovery lead persistent pain. Scar tissue, characterized by a highly disorganized fibrotic extracellular matrix, serve as physical barrier regeneration drug delivery. While approaches such drugs, biomaterials, cells, external stimulation, other forces show promise mitigating scarring promoting regenerative healing, their implementation remains limited challenging. Ultrasound, laser, electrical, magnetic forms stimulation have been utilized promote soft tissue well neural regeneration. After tissues experience increased proliferation Schwann secretion neurotropic factors, production myelin, growth all aimed at supporting axon innervation. Yet, outcomes vary depending on pathophysiology damaged nerve, timing following injury, specific parameters employed. Increased treatment intensity duration noted hinder process inducing damage. These modalities, either alone or combination with nerve guidance conduits scaffolds, demonstrated healing. However, literature currently lacks detailed understanding used for applications. In this article, we aim address gap summarizing existing reports providing an overview alongside associated outcomes.

Language: Английский

Citations

5
Assessment of CRISPRa-mediated gdnf overexpression in an In vitro Parkinson’s disease model DOI Creative Commons
Paula Guzmán-Sastoque,

Sebastián Sotelo,

Natalia P. Esmeral

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 8, 2024

Introduction Parkinson’s disease (PD) presents a significant challenge in medical science, as current treatments are limited to symptom management and often carry side effects. Our study introduces an innovative approach evaluate the effects of gdnf overexpression mediated by CRISPRa vitro model disease. The expression can have neuroprotective effects, being related modulation neuroinflammation pathways associated with cell survival, differentiation, growth. Methods We developed targeted delivery system using magnetite nanostructured vehicle for efficient transport genetic material. This has resulted substantial increase, up 200-fold) In mixed primary culture astrocytes, neurons, microglia. Results Discussion exhibits endosomal escape more than 56%, crucial effective activation material within cells. increased correlates notable reduction MAO-B complex activity, reaching basal values 14.8 μU/μg protein, reactive oxygen species. Additionally, there is 34.6% increase viability treated neurotoxin MPTP. shows that increasing remediate some cellular symptoms novel system.

Language: Английский

Citations

5