Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 26, 2025
Abstract
The
clinical
progress
of
tumor
nucleotide
vaccines
is
limited
due
to
insufficient
recognition
and
killing
cells
with
low
antigen
expression
by
cytotoxic
T
lymphocytes
(CTL).
Here,
natural
cholesterol
analogs
are
screened
assemble
self‐adjuvant
lipid
nanoparticles
(LNPs)
for
antigens
tagging
dendritic
(DC)
activation.
First,
a
library
ginsenosides
collected,
then
according
their
anti‐tumor
immunity.
Then,
ginsenoside‐Rg3
based‐LNPs
loaded
(Rg3‐LNPs)
identified
as
the
optimal
formulation
investigating
physicochemical
biological
properties.
Finally,
Rg3‐LNPs
granulocyte‐macrophage
colony‐stimulating
factor
(GM‐CSF)
co‐loaded
into
macroporous
hydrogel
long‐term
immune
response.
could
accumulate
both
tumors
LNs.
targeted
high
glucose
transporter‐1
via
targeting
ligand
Rg3,
anchored
on
cell
surface,
thus
promoting
CTL
cells;
can
LNs
promote
DC
activation
presentation,
stimulating
Besides,
an
adjuvant,
cooperated
GM‐CSF
remodel
microenvironment,
cells.
Collectively,
this
work
highlights
importance
in
vaccine
has
great
value
immune‐escaping
tumors.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(6), P. 1201 - 1201
Published: March 7, 2025
Breast
cancer
(BC)
tops
the
list
of
causes
for
female
fatalities
globally,
with
elusive
triple-negative
breast
(TNBC)
constituting
10–20%
all
cases.
Current
clinical
strategies
combating
TNBC
encompass
a
multifaceted
approach,
including
surgical
intervention,
radiation
therapy,
chemotherapy,
and
advanced
targeted
drugs
immunotherapies.
While
these
modalities
have
catalyzed
significant
advancements
in
management,
lingering
limitations
continue
to
pose
formidable
challenges.
There
is
an
acute
need
novel
therapeutics
realm
treatment.
Natural
products
(NPs)
emerged
as
rich
reservoir
pharmaceutical
innovation,
owing
their
extraordinary
range
structures
physicochemical
properties.
Scholars
reported
diverse
evidence
NPs’
efficacy
against
TNBC.
This
review
aims
comprehensively
explore
bioactive
constituents,
specifics
commonalities
chemical
structure,
pharmacological
mechanisms
NPs,
specifically
examining
roles
impeding
which
recently
garnered
interest,
are
intriguing
terms
capacity
combat
through
mechanisms,
suppression
tumor
cell
proliferation,
induction
apoptosis,
inhibition
metastasis.
These
natural
agents
primarily
compounds,
terpenoids,
glycosides,
phenolic
alkaloids.
An
in-depth
exploration
has
unveiled
involvement
key
signaling
pathways,
transforming
growth
factor-beta
(TGF-β),
vascular
endothelial
factor
A
(VEGFA),
phosphoinositide
3-kinase/protein
kinase
B
(PI3K/AKT),
Wingless/Int-1
(Wnt)
/β-catenin,
mitogen-activated
protein
(MAPK)
pathways.
Meanwhile,
this
also
looks
at
challenges
opportunities
that
arise
from
harnessing
compounds
influence
TNBC,
while
outlining
prospective
trajectory
future
research
field
NPs.
iScience,
Journal Year:
2025,
Volume and Issue:
28(5), P. 112274 - 112274
Published: March 22, 2025
Breast
cancer
is
a
fatal
malignancy
facing
human
health,
with
most
patients
experiencing
recurrence
and
resistance
to
chemotherapy.
The
immunosuppressive
tumor
microenvironment
(TME)
greatly
limits
the
actual
outcome
of
immunotherapy.
This
study
aimed
develop
modality
theranostics
nanoparticles
for
breast
based
on
near-infrared
light-triggered
nanoparticle
targeted
delivery
ginsenoside
Rg3
immune
adjuvants
imiquimod
(R837)
effective
Folate-receptor
(FA)
targeting
IR780-R837/ginsenoside
Rg3-perfluorohexane
(PFH)
@
polyethylene
glycol
(PEG)-poly
(lactide-co-glycolic
acid)
(PLGA)
(FA-NPs)
can
be
activated
by
laser
irradiation
in
tumors,
which
leads
rapid
release
R837
regions
high
expression
folate
receptors
glucose
transporter
1
(GLUT1).
Meanwhile,
used
as
dual-mode
contrast
agents
photoacoustic
ultrasound
imaging.
strategy
provides
strong
memory
effect,
prevent
after
eliminating
initial
tumor.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 26, 2025
Abstract
The
clinical
progress
of
tumor
nucleotide
vaccines
is
limited
due
to
insufficient
recognition
and
killing
cells
with
low
antigen
expression
by
cytotoxic
T
lymphocytes
(CTL).
Here,
natural
cholesterol
analogs
are
screened
assemble
self‐adjuvant
lipid
nanoparticles
(LNPs)
for
antigens
tagging
dendritic
(DC)
activation.
First,
a
library
ginsenosides
collected,
then
according
their
anti‐tumor
immunity.
Then,
ginsenoside‐Rg3
based‐LNPs
loaded
(Rg3‐LNPs)
identified
as
the
optimal
formulation
investigating
physicochemical
biological
properties.
Finally,
Rg3‐LNPs
granulocyte‐macrophage
colony‐stimulating
factor
(GM‐CSF)
co‐loaded
into
macroporous
hydrogel
long‐term
immune
response.
could
accumulate
both
tumors
LNs.
targeted
high
glucose
transporter‐1
via
targeting
ligand
Rg3,
anchored
on
cell
surface,
thus
promoting
CTL
cells;
can
LNs
promote
DC
activation
presentation,
stimulating
Besides,
an
adjuvant,
cooperated
GM‐CSF
remodel
microenvironment,
cells.
Collectively,
this
work
highlights
importance
in
vaccine
has
great
value
immune‐escaping
tumors.
