International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136392 - 136392
Published: Oct. 1, 2024
Language: Английский
Advanced Therapeutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 19, 2025
Abstract Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal (GI) tract with an uncertain etiology. Currently, IBD therapy relies on induction clinical remission followed by maintenance using anti‐inflammatory drugs and immunosuppressants; however, definite cure still out scope. Established approaches are characterized adverse drug‐related side effects that can even be potentially life‐threatening. In contrast, increased interest remarkable scientific progress in targeted drug delivery systems offer promising approach to reduce systemic events, delivering therapeutic substances only inflamed tissue. All alteration barrier integrity, especially disturbed epithelial barrier, unique pattern receptors cell surface and/or oxidative stress milieu areas used as effective for controlled delivery. Hence, this review focuses pathophysiology GI potential strategy polymeric nanoparticles treatment. Interdisciplinary efforts between chemistry gastroenterology/immunology promise create novel synergies improve development nanoparticle significant impact. regard, current challenges translation nanomedicine also discussed.
Language: Английский
Citations
0
Food Research International, Journal Year: 2025, Volume and Issue: 204, P. 115916 - 115916
Published: Feb. 4, 2025
Language: Английский
Citations
0
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Designing innovative strategies for oral delivery of active compounds is particularly promising the treatment intestinal diseases such as ulcerative colitis (UC).
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 673, P. 125375 - 125375
Published: Feb. 16, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141567 - 141567
Published: Feb. 27, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 337 - 337
Published: March 5, 2025
Nanoemulsions (NEs) have emerged as effective drug delivery systems over the past few decades due to their multifaceted nature, offering advantages such enhanced bioavailability, protection of encapsulated compounds, and low toxicity. In present review, we focus on advancements in last five years across (trans)dermal, oral, ocular, nasal, intra-articular administration routes using NEs. Rational selection components, surface functionalization, incorporation permeation enhancers, functionalization with targeting moieties are explored for each route discussed. Additionally, apart from NEs, explore NE-based (e.g., gels) while highlighting emerging approaches vaccination theranostic applications. The growing interest NEs purposes is reflected clinical trials, which also By summarizing latest advances, exploring new strategies, identifying critical challenges, this review focuses developments efficient therapeutic approaches.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2894 - 2894
Published: March 22, 2025
Inflammatory bowel disease (IBD) is a chronic and refractory with increasing incidence, adversely impacting millions of patients worldwide. Current therapeutic strategies for IBD often exhibit considerable adverse effects, limited efficacy, high tendency recurrence, highlighting the urgent need novel agents. Hydrogel, three-dimensional hydrophilic network polymer material known its excellent biocompatibility responsiveness to stimuli, has been effectively utilized as drug carrier across various systems. The hydrogels' application in treatment holds significant promise enhancing outcomes. This review synthesizes recent advancements leveraging hydrogels carriers management. discussion encompasses response mechanisms hydrogels, their therapy, methods administration. As delivery matrices, potential treating IBD.
Language: Английский
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0
Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Nowadays, during hydrogel formulation design, the focus is primarily on polymers and cross-linkers. It crucial to ensure a high level of biocompatibility degradability, along with appropriate physico-chemical properties. However, other ingredients can also influence formation performance. Therefore, this study examines effect different salt molarities in phosphate buffered saline (PBS) solutions, used as reaction solvents, properties hydrogels mainly composed polyethylene glycol, agarose, carbomer. To conduct study, two PBS solutions are prepared by varying concentrations, these mixtures solvents bulk polycondensation reaction. Subsequently, formulations obtained characterized analyze concentration material An increase reduced swelling capacity release ability matrix, well decreased porosity interconnectivity material, contributing non-homogeneity pore network. Consequently, results highlight that salinity ionic strength buffering affect various properties, therefore, careful consideration should be given preparation solutions.
Language: Английский
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Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(2)
Published: April 1, 2025
Language: Английский
Citations
0
Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102674 - 102674
Published: April 1, 2025
Language: Английский
Citations
0