Extracellular vesicle miRNAs for predicting the efficacy of late-line treatment with anlotinib in patients with lung adenocarcinoma DOI Creative Commons

Aimi Huang,

Fuchuang Zhang,

Jiyang Zhang

et al.

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 2, 2024

Abstract Background Anlotinib is a targeted therapy indicated for some malignancies, including advanced non-small cell lung cancer (NSCLC). However, noninvasive biomarkers identifying patients who will benefit from this disease remain lacking. Methods Here, we investigated the potential of small extracellular vesicle (sEV) microRNAs (miRNAs) as predictive anlotinib efficacy. A total 20 NSCLC were enrolled. Patients classified having stable (SD) or progressive (PD) after initial efficacy assessment. Results Seven differentially expressed miRNAs (DEMs) identified. Among them, miR-941 was significantly upregulated in PD group, while others downregulated. Furthermore, these six downregulated (miR-30a-3p, miR-150-5p, miR-122-5p, miR-10b-5p, miR-92a-3p, and miR-150-3p) more pronounced nonsmoking patients. Conclusions It found that sEV have to predict anlotinib.

Language: Английский

Unraveling Extracellular Vesicle DNA: Biogenesis, Functions, and Clinical Implications DOI

Mehraneh Nouri,

F Nasiri,

Samaneh Sharif

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155937 - 155937

Published: March 1, 2025

Language: Английский

Citations

0
ECM-binding properties of extracellular vesicles: advanced delivery strategies for therapeutic applications in bone and joint diseases DOI Creative Commons
Peng Wang, Johanna F.A. Husch, Onno J. Arntz

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 2, 2025

Abstract Extracellular vesicles (EVs) and the extracellular matrix (ECM) are essential in maintaining bone joint health by facilitating intercellular communication, regulating tissue processes providing structural support. EVs with a large surface area carry diverse biomolecules to steer function of cells their surroundings. To understand how localize specific sites, we here review available knowledge on EV interactions ECM components that crucial for remodeling, cartilage maintenance, immune responses, playing roles both homeostasis pathological conditions, such as arthritis osteoporosis. More importantly, using analyses animal experimental data, illustrate effect ECM-based biomaterials (e.g. hydrogels, decellularized matrices, ECM-mimetic scaffolds) carriers toward effective delivery regenerative immunomodulatory therapies tissue. These enable sustained release targeted EVs, promoting regeneration. The insights this can be utilized advance development cutting-edge skeletal regeneration disease management.

Language: Английский

Citations

0
The multifaceted roles of extracellular vesicles in osteonecrosis of the femoral head DOI

Hongxu Li,

Haoyang Liu, Yu Zhou

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 52, P. 70 - 84

Published: April 10, 2025

Language: Английский

Citations

0
The extracellular vesicles in HIV infection and progression: mechanisms, and theranostic implications DOI Creative Commons
Zhen Tang,

Yao Lu,

Jiu-Long Dong

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: April 9, 2024

Extracellular vesicles (EVs), these minute yet mighty cellular messengers are redefining our understanding of a spectrum diseases, from cancer to cardiovascular ailments, neurodegenerative disorders, and even infectious diseases like HIV. Central communication, EVs emerge as both potent facilitators insightful biomarkers in immune response the trajectory disease progression. This review ventures deep into realm HIV-unraveling their pivotal roles diagnosis, mechanism unravelling, therapeutic innovation. With focus on HIV, we will highlights transformative potential diagnosing treating this formidable virus. Unveiling intricate dance between aims shed light novel strategies that could significantly benefit HIV therapy, potentially leading eradication

Language: Английский

Citations

2
Transforming Medicine with Nanobiotechnology: Nanocarriers and Their Biomedical Applications DOI Creative Commons
Arun Karnwal, Vikas Sharma, Gaurav Kumar

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1114 - 1114

Published: Aug. 23, 2024

Nanobiotechnology, at the intersection of nanotechnology and biology, represents a burgeoning field poised to revolutionize medicine through use advanced nanocarriers. These nanocarriers, endowed with distinctive physiobiological attributes, are instrumental in diverse therapeutic domains including drug delivery for microbial infections, cancer treatment, tissue engineering, immunotherapy, gene therapy. Despite transformative potential, several challenges hinder their efficacy, such as limited capacity, suboptimal targeting, poor solubility. This review delves into latest advancements nanocarrier technologies, examining properties, associated limitations, innovative solutions developed address these issues. It highlights promising systems like nanocomposites, micelles, hydrogels, microneedles, artificial cells that employ conjugation techniques, sustained stimulus-responsive release mechanisms, enhanced By exploring novel structures contributions overcoming existing barriers, article emphasizes vital role interdisciplinary research advancing nanobiotechnology. offers unparalleled opportunities precise effective delivery, underscoring its potential reshape healthcare personalized, targeted treatments improved performance.

Language: Английский

Citations

1
Extracellular vesicles in pulmonary infection: From pathophysiology to theranostic technologies DOI
Xu Wang,

Mai-Qing Shi,

Yang Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155585 - 155585

Published: Sept. 8, 2024

Language: Английский

Citations

1
Advancing Roles and Therapeutic Potentials of Pyroptosis in Host Immune Defenses against Tuberculosis DOI Creative Commons

Jiayi Yang,

Yuhe Ma,

Jiaqi Yu

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1255 - 1255

Published: Oct. 4, 2024

Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb) infection, remains a deadly global public health burden. The use of recommended drug combinations in clinic has seen increasing prevalence drug-resistant TB, adding to the impediments control TB. Therefore, TB and become one most pressing issues health, which urges exploration potential therapeutic targets Pyroptosis, form programmed cell death characterized swelling rupture, release cellular contents inflammatory responses, been found promote pathogen clearance adopt crucial roles bacterial infections. It demonstrated that Mtb can cause host pyroptosis, these cells, are infected Mtb, kill accompanied while, at same time, pyroptosis also intracellular may potentially worsen infection exacerbating inflammation. Here, we describe main pathways during summarize identified effectors regulate achieve immune evasion. Moreover, discuss potentials serve as anti-TB target, with aim providing new ideas for development treatments.

Language: Английский

Citations

1
Advances in nanotechnology-based approaches for the treatment of head and neck squamous cell carcinoma DOI Creative Commons

Bicai Tang,

Rui Huang,

MA Wen-juan

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(52), P. 38668 - 38688

Published: Jan. 1, 2024

Head and neck squamous cell carcinoma (HNSCC), one of the most common types cancers occurring in head region, is often associated with high mortality rates due to its invasiveness morbidity. The mainstream treatment methods clinical settings, including surgery, chemotherapy, radiotherapy, may cause poor overall survival rate prognosis, issues such as drug resistance, damage adjacent healthy tissues, potential recurrences. Other approaches immunotherapy, photodynamic therapy (PDT), photothermal (PPT) also suffer from inefficient tumor targeting suboptimal therapeutic outcomes. Early detection vital for HNSCC patients, but it always limited by insensitivity confusing manifestations. Hence, highly desirable develop optimized diagnostic strategies. With boom nanomaterials, nanotechnology-conducted has attracted widespread attention. Nanoparticles (NPs) are distinguished their unique morphology superior physicochemical property, some can exhibit direct antitumor activity, while others serve promising candidates delivery. In addition, NPs offer structural modification delivery targeting, enabling specific cells through conjugation biomarker ligands improving cargo biocompatibility. This work reviews current therapies diagnosis HNSCC, highlights characteristics major NPs, surveys uses advantages discusses obstacles prospects applications, aiming enlighten future research directions nanotechnology-based HNSCC.

Language: Английский

Citations

1
Material informatics-driven insights into brain cancer nanocarriers: A bibliometric comparison of PLGA vs. liposomes DOI Creative Commons

Brilly Andro Makalew,

Syauqi Abdurrahman Abrori

OpenNano, Journal Year: 2024, Volume and Issue: 21, P. 100225 - 100225

Published: Dec. 11, 2024

Language: Английский

Citations

1
Extracellular vesicle miRNAs for predicting the efficacy of late-line treatment with anlotinib in patients with lung adenocarcinoma DOI Creative Commons

Aimi Huang,

Fuchuang Zhang,

Jiyang Zhang

et al.

Cancer Nanotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 2, 2024

Abstract Background Anlotinib is a targeted therapy indicated for some malignancies, including advanced non-small cell lung cancer (NSCLC). However, noninvasive biomarkers identifying patients who will benefit from this disease remain lacking. Methods Here, we investigated the potential of small extracellular vesicle (sEV) microRNAs (miRNAs) as predictive anlotinib efficacy. A total 20 NSCLC were enrolled. Patients classified having stable (SD) or progressive (PD) after initial efficacy assessment. Results Seven differentially expressed miRNAs (DEMs) identified. Among them, miR-941 was significantly upregulated in PD group, while others downregulated. Furthermore, these six downregulated (miR-30a-3p, miR-150-5p, miR-122-5p, miR-10b-5p, miR-92a-3p, and miR-150-3p) more pronounced nonsmoking patients. Conclusions It found that sEV have to predict anlotinib.

Language: Английский

Citations

0