Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications disease treatment. HA possesses good biocompatibility, biodegradability, and ability to interact various cell surface receptors. Its wide range of molecular weights modifiable chemical groups make it an effective drug carrier for delivery. Additionally, overexpression specific receptors on surfaces many states enhances accumulation drugs at pathological sites through receptor binding. In this review, modification drugs, major proteins, latest advances receptor‐targeted nano delivery systems (DDS) treatment tumors inflammatory diseases are summarized. Furthermore, functions varying vivo selection methods different discussed.

Language: Английский

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Delivery of natural products via polysaccharide-based nanocarriers for cancer therapy: A review on recent advances and future challenges

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 135072 - 135072

Published: Aug. 25, 2024

Language: Английский

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Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 5, 2025

Severe acute pancreatitis (SAP) has high morbidity, a complicated and dangerous course, many complications, including severe pulmonary complications. SAP-associated lung injury (SAP-ALI) is still significant challenge for surgeons because of its mortality. Therefore, more effective treatment methods are urgently needed. Emodin (EMO) shown tremendous potential in treating refractory diseases. However, protection mechanism SAP-ALI needs to be further clarified. This study was undertaken investigate the protective effects EMO against SAP rats alveolar epithelial cells, with particular focus on classical ferroptosis pathway. In an vivo study, forty SD were evenly split into five groups: sham operation (SO) group, biliopancreatic duct retrogradely injected 5% sodium taurocholate (STC) create + group administered via gavage following modeling, ML385 (a given inhibitor nuclear factor erythroid 2-related 2 (Nrf2)), group. vitro A549 cell lines exposed lipopolysaccharide (LPS) treated EMO. also used inhibit expression Nrf2. Pancreatic tissue damage evaluated using histological examination molecular experiments. Enzyme-linked immunosorbent assays (ELISA) assess levels pro-inflammatory cytokines, Fe2+, associated oxidative stress indicators serum supernatant. Real-time polymerase chain reaction (PCR), Western blot (WB), immunofluorescence find expressions related mRNAs proteins or cells. The findings demonstrated that suppressing Nrf2 exacerbated inflammatory response brought by pathological alterations SAP-ALI. reversed this change activating Nrf2/Heme Oxygenase-1 (HO-1)/glutathione peroxidase 4 (GPX4) signal path. Moreover, these results showed EMO, contrary ML385, suppressed response, which manifested as up-regulated glutathione (GSH) GPX4 down-regulated malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxygen species (ROS) levels. Our effectively inhibited both vitro, while modulating Nrf2/HO-1/GPX4 signaling pathway provide

Language: Английский

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Pharmaceutical chitosan hydrogels: A review on its design and applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135775 - 135775

Published: Sept. 1, 2024

Language: Английский

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Preparation of Biomimetic Selenium–Baicalein Nanoparticles and Their Targeted Therapeutic Application in Nonsmall Cell Lung Cancer

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(9), P. 4476 - 4489

Published: Aug. 6, 2024

In this study, we prepared bionic selenium-baicalein nanoparticles (ACM-SSe-BE) for the targeted treatment of nonsmall cell lung cancer. Due to coating A549 membrane, system has homologous targeting capabilities, allowing preparation target tumor cells. The borate ester bond between selenium (SSe) and baicalein (BE) is pH-sensitive can break under acidic conditions in microenvironment achieve release BE at site. Moreover, SSe further enhances antitumor effect by increasing production ROS Transmission electron microscopy (TEM) images dynamic light scattering (DLS) showed that ACM-SSe-BE had a particle size approximately 155 ± 2 nm. FTIR verified successful coupling BE. vitro experiments indicated cumulative pH 5.5 after 24 h was 69.39 1.07%, which less than 20% 7.4, confirming ACM-SSe-BE. Cell uptake vivo imaging good ability. results MTT, flow cytometry, Western blot, immunofluorescence staining demonstrated promoted apoptosis inhibited proliferation. were consistent with those experiments. These clearly suggested will be promising nanosystem

Language: Английский

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Emodin in-situ delivery with Pluronic F-127 hydrogel for myocardial infarction treatment: Enhancing efficacy and reducing hepatotoxicity

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122963 - 122963

Published: Aug. 8, 2024

Language: Английский

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Thermosensitive bovine lactoferricin-loaded chitosan hydrogels for sustained antibacterial release: An alternative to antibiotics for treating bovine mastitis

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 303, P. 140673 - 140673

Published: Feb. 3, 2025

Language: Английский

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Polysaccharides as submucosal injection materials (SIMs) in endoscopic resection: A comprehensive review

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 355, P. 123360 - 123360

Published: Feb. 5, 2025

Language: Английский

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Enhancing Efficacy and Mitigating Toxicity of Semen Strychni: From Traditional Practices to Modern Pharmaceutical Innovations

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119515 - 119515

Published: Feb. 1, 2025

Language: Английский

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Systematically investigate the mechanism underlying the therapeutic effect of emodin in treatment of prostate cancer

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 27, 2025

To systematically investigate the mechanism underlying therapeutic effect of emodin in treatment prostate cancer. Combine network pharmacology, molecular docking, dynamics and experimental verification to explored mechanism. Using pharmacology method, through TCMSP, DisGeNET Genecards database, corresponding targets related signaling pathways were screened, core studied by docking uasing Cytoscape 3.7.2 other software. The biological processes, cellular components functions key determined GO enrichment analysis. KEGG analysis identified associated with targets. GEPIA Kaplan–Meier database used determine relationship between expression genes normal people cancer patients prognosis patients. Cell proliferation inhibition experiment was carried out MTT method. mRNA protein levels CASP3, TNF, IL1B, TP53, PPARG, MYC PC-3 cells evaluated RT-PCR WB method respectively. There 31 common which closely PPI showed that MYC, IL1B Go IL-17 pathway pathways. Molecular results indicated had good binding 6 proteins, force TP53 strongest most stable. CASP3 stronger than cancer, survival rate Experimental result revealed EM significantly increased expressions PPARG decreased at concentrations ranging from 0.1 1.6 μmol/L. Emodin 10 160 µmol/L. have best stable conformation among genes. exhibits a significant inhibitory on concentration 0.4 ~ It anti-prostate properties regulating 1L-17 up-regulating genes/proteins, down-regulating genes/proteins.

Language: Английский

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