International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138493 - 138493
Published: Dec. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143136 - 143136
Published: April 1, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 16, 2025
Cartilage tissue engineering has made significant strides in clinical regenerative treatment. The success of cartilage regeneration critically depends on a favorable microenvironment by means ideal bioactive scaffolds. However, total meniscus replacement frequently entails harsh accompanying chronic inflammation and oxidative stress conditions after massive injury, which extremely hinders repair. Herein, "core-shell" codelivery nanocarrier is developed to synergistically regulate the cartilaginous immune (CIME) for replacement. In this study, mesoporous silica nanoparticles are used encapsulate an antioxidant anti-inflammatory drug, Emodin, core meanwhile modify growth differentiation factor (GDF) reversible disulfide bonds shell, together constructing system (Em@MSN-GDF). synergistic dual-drug release effectively reverses followed successful promotion fibrocartilage vivo. Subsequently, Em@MSN-GDF-loaded cartilage-specific matrix hydrogels combined with meniscus-shaped polycaprolactone framework construct mechanically reinforced living substitute. As result, rabbit experiments demonstrate that regulates microenvironment, thereby achieving regeneration. current therefore, offers nanotreatment strategy reverse
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137129 - 137129
Published: Oct. 31, 2024
Language: Английский
Citations
3
Small, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 18, 2024
Triple-negative breast cancer (TNBC), characterized by its aggressive metastatic propensity and lack of effective targeted therapeutic options, poses a major challenge in oncological management. A proof-of-concept neoadjuvant strategy aimed at inhibiting TNBC tumor growth mitigating metastasis through localized delivery chemotherapeutics is reported this paper. This approach addresses the limitations payload capacity stimuli responsiveness commonly associated with microrobotics oncology. hydrogel-based system developed for immobilization chemotherapeutic agents, subsequently encapsulated within magnetically responsive microrobots. design leverages external magnetic fields to facilitate precise navigation localization agents directly site. The efficacy demonstrated an animal model, which significant 14-fold reduction size suppression critical organs such as liver lungs are observed. Crucially, drug release mechanism engineered be microenvironment regulated overexpression enzymatic activity matrix metalloproteinases (MMP2 MMP9) tumors, triggering degradation hydrogel matrix, leading controlled immobilized drug. ensures that action localized, reducing systemic toxicity enhancing treatment efficacy. These findings suggest holds promise broader applications other types.
Language: Английский
Citations
3
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 4257 - 4275
Published: July 1, 2024
Introduction: Although sertraline has been widely used for chronic prostatitis (CP), the mechanisms are unclear. Herein, we explored of in treating CP. Methods: Network pharmacology methods were to explore potential targets and molecular mechanisms. LPS was stimulate RWPE-1 cells construct an vitro model An experimental autoimmune (EAP) mice built. CCK-8 assay, EdU BrdU detection, Tunel assay performed evaluate proliferation apoptosis process or tissues, respectively. DCFH-DA Fluo-4 fluorescence probes detect intracellular ROS calcium concentrations. Von Frey filaments open-field tests utilized pain response depressive-like behavior mice. Histopathology evaluated through hematoxylin eosin staining. RT-qPCR, Western blot, immunofluorescence, immunohistochemistry transcription, expression, location related proteins. Molecular dynamics (MD) simulation surface plasmon resonance (SPR) measure binding capacity Results: Through a network analysis, 27 CP obtained, 5 key (CHRM1, ADRA1B, HTR2B, HTR2A, TRPV1) finally identified. Functional experiments suggested that TRPV1 involved proliferation, inhibition, production LPS-induced cells. In showed significantly inhibited cell generation, transcription inflammation cytokines Additionally, markedly promoted level LPS-stimulated elevated expression BAX while reducing levels Bcl2 Caspase-3. MD SPR confirmed direct TRPV1. Moreover, down-regulated influx agonist (Capsaicin) restored effects on apoptosis, production, Mice demonstrated treatment could reduce response, improve depression-like symptoms, relieve local prostate EAP mice, as well TRPV1, inhibit promote tissues Discussion: The results revealed anti-inflammatory effect mechanism regulating channel. It indicated might serve complementary agent Keywords: prostatitis, sertraline, RWPE-1,
Language: Английский
Citations
2
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 223, P. 237 - 249
Published: Aug. 1, 2024
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135777 - 135777
Published: Sept. 1, 2024
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138493 - 138493
Published: Dec. 1, 2024
Language: Английский
Citations
0