Excessive glutathione intake contributes to chemotherapy resistance in breast cancer: a propensity score matching analysis DOI Creative Commons
Zhiyuan Zhang, Jian Gao,

Linjiao Jia

et al.

World Journal of Surgical Oncology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 21, 2024

We aim to explore the impact of excessive glutathione (GSH) intake on chemotherapy sensitivity in breast cancer. Clinicopathological data were collected from 460 cancer patients who underwent adjuvant January 2016 December 2019 Zhengzhou University People's Hospital. The clinicopathological characteristics following GSH treatment and compared with those Non-GSH group after 1:2 propensity score matching (PSM). Intracellular levels expression antioxidant enzymes (NRF2, GPX4 SOD1) evaluated tumor tissues 51 receiving neoadjuvant chemotherapy. recurrence rate was significantly higher (n = 28, 31.8%) than that 39, 22.2%; P 0.010). Additionally, HGSH (high intake, ≥ 16 days) exhibited an elevated LGSH (low < 15 (46.8%) vs. n 52 (22.4%); 0.003). Cox regression revealed High Ki67 30%, Triple negative Lymphovascular invasion independent risk factors progression Among chemotherapy, intracellular resistant substantially (P 0.001). Excessive may contribute resistance cancer, are indicating standardization assist reducing resistance.

Language: Английский

Natural enzyme cascade bimetallic sulfide MoCuSx nanozyme for synergistic photothermal/photodynamic enhanced chemodynamic antimicrobial therapy of wound infection DOI

Caiyun Xu,

Junqin Li,

Chunlei Ou

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156170 - 156170

Published: Sept. 1, 2024

Language: Английский

Citations

6
A pH/GSH Dual‐Responsive Triple Synergistic Bimetallic Nanocatalyst for Enhanced Tumor Chemodynamic Therapy DOI Open Access
Lu Zhang,

Huan Shen,

Tingting Liu

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Chemodynamic therapy (CDT) has garnered significant attention in the field of tumor due to its ability convert overexpressed hydrogen peroxide (H 2 O ) tumors into highly toxic hydroxyl radicals (•OH) through metal ion‐mediated catalysis. However, effectiveness CDT is hindered by low catalyst efficiency, insufficient intra‐tumor H level, and excessive glutathione (GSH). In this study, a pH/GSH dual responsive bimetallic nanocatalytic system (CuFeMOF@GOx@Mem) developed modifying red blood cell membranes onto glucose oxidase (GOx)‐loaded Fe‐Cu MOFs, enhancing efficacy triple‐enhanced way self‐supply, catalysts self‐cycling, GSH self‐elimination. Upon accumulation tissues facilitated membrane, GOx initiates reaction with generate gluconic acid situ. Subsequently, reduced pH triggers release Fe 3+ Cu 2+ from CuFeMOF@GOx@Mem, which immediately turned + GSH, activating ‐mediated Fenton reaction. More importantly, can also act as an accelerator /Fe conversion, meanwhile, generated be further GSH. Consequently, sustained well elimination are achieved simultaneously, providing unique approach for improving anti‐tumor CDT.

Language: Английский

Citations

0
H2O2‐Generating Advanced Nanomaterials for Cancer Treatment DOI Creative Commons
Kiyan Musaie, Samin Abbaszadeh,

Kik Marais

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Tumor cells exploit abnormal redox homeostasis and the pro‐tumorigenic effect of reactive oxygen species (ROS) to enhance their survival progression. However, excessively high levels ROS can exceed oxidative stress threshold tumor cells, inducing cell death. This occur by selectively elevating concentration H 2 O in through both endogenous exogenous mechanisms. The generated serves as a precursor for toxic ROS, such • OH 1 , via chemodynamic photodynamic therapy, respectively, leading apoptosis, necrosis, ferroptosis. Strategies boost include direct delivery amplifying generation inhibiting antioxidant enzymes, leveraging glucose oxidase, employing photocatalytic therapy (PCT), utilizing metal peroxides. Among them, peroxides have displayed remarkable performance due excellent potential elevate within while simultaneously normalizing acidic hypoxic conditions microenvironment (TME). Moreover, these nanostructures sensitivity complementary treatments, like chemotherapy. review summarizes advanced perspectives design, synthesis, comparative analysis ‐generating nanoplatforms, emphasizing capacity treat various cancers.

Language: Английский

Citations

0
Bifunctional cobalt ferrite/reduced graphene oxide heterojunction enhances the antibacterial and osteogenic activities of scaffold DOI
Cijun Shuai, Chong Lin, Xiuwen Gao

et al.

Applied Surface Science, Journal Year: 2025, Volume and Issue: unknown, P. 162942 - 162942

Published: March 1, 2025

Language: Английский

Citations

0
FeS embedded bioreactor collaborate with artesunate for cascade-catalytic tumor ferroptosis DOI
Xiaoyu Wang, Chunming Xu, Hui Tian

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137479 - 137479

Published: March 1, 2025

Language: Английский

Citations

0
Lipid acid metabolism reprogramming nanoagent induces ferroptosis storm and cGAS-STING activation for metal-immunotherapy of triple negative breast cancer DOI
Dawei Zhou, Gaorui Zhang,

J. Zhu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162048 - 162048

Published: April 1, 2025

Language: Английский

Citations

0
Targeted and intelligent nano-drug delivery systems for colorectal cancer treatment DOI Creative Commons

Meihong Chai,

Shihua Wang, Yuxin Chen

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 25, 2025

Colorectal cancer (CRC) remains a highly heterogeneous malignancy with significant morbidity and mortality worldwide. Despite advancements in surgery, chemotherapy, immunotherapy, targeted therapy, treatment efficacy is often hampered by drug resistance systemic toxicity. In recent years, nano-drug delivery systems (NDDS) have emerged as promising strategy to enhance therapeutic precision, reduce adverse effects, overcome CRC treatment. This review discusses the NDDS for treatment, focusing on optimization of oral systems, development tumor-specific targeting strategies, design intelligent responsive tumor microenvironment (TME). Furthermore, we summarize current challenges translation explore future research directions enhancing their clinical feasibility impact.

Language: Английский

Citations

0
Controllable All-in-One Biomimetic Hollow Nanoscaffold Initiating Pyroptosis-Mediated Antiosteosarcoma Targeted Therapy and Bone Defect Repair DOI

Qiming Ma,

Shenglin Xu,

Qian Wang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(49), P. 67424 - 67443

Published: Nov. 27, 2024

Pyroptosis has gained attention for its potential to reinvigorate the immune system within tumor microenvironment. However, current approaches employing pyroptosis inducers suffer from limitations. They primarily rely on single agents, lack precise targeting, and potentially disrupt intricate bone formation microenvironment, hindering local repair of tumor-induced defects. Therefore, a therapeutic strategy is urgently needed that can effectively trigger while simultaneously promoting regeneration. This research introduces an all-in-one construct designed address these It combines cell-camouflaged shell with autosynergistic reactive oxygen species (ROS) generating polymer. incorporates hollow core manganese dioxide (HMnO2) embedded photosensitizer IR780 disguised by cell membrane M1 macrophage. The macrophage grants stealth-like properties, enabling it accumulate selectively at site. Upon laser irradiation, acts as exogenous ROS generation converting light energy into heat. Additionally, structure HMnO2 serves efficient carrier IR780. Furthermore, Mn4+ ions released deplete glutathione (GSH) tumor, further amplifying production. synergistic cascade ultimately culminates in induction through caspase-3-mediated cleavage gasdermin E (GSDME) upon activation. Meanwhile, depletion GSH microenvironment (TME) leads Mn2+ ions. These establish supportive milieu, which promotes transformation marrow mesenchymal stem cells (BMSCs) mature cells. This, turn, defects rat femurs. Our findings strongly indicate may be osteosarcoma treatment, presents robust versatile approach targeted therapy tissue regeneration this patient population.

Language: Английский

Citations

0
Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity DOI
Xu Guo, Xin Liang, Jiale Liu

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

The emerged apoptosis/ferroptosis synergistic platinum-based therapy has attracted a lot of attention but is far from clinic use due to high systemic toxicity. Herein, series novel precise carrier-free self-assembled platinum(IV) nanoparticles with lipid regulation effect named FSPNPs (5NPs–8NPs) were constructed via connecting fenofibrate acid (FA) cisplatin or oxaliplatin-derived platinum(IV)-intermediates disulfide bonds. can be stimulated by high-glutathione/ascorbic and acidity environment produce an "explosion-like" cascade release process. Cell-activity showed precision FSPNPs, which accumulated more in tumor cells inhibited cell proliferation. Especially, 5NPs have higher selectivity than cisplatin. downregulated glutathione/glutathione peroxidase 4, increased reactive oxygen species/lipid peroxidation/malondialdehyde, induced DNA damage/S-phase arrest, regulated p53/Bcl-2/Bax trigger the hybrid pathway. released FA derivates docked into peroxisome proliferator-activated receptor α activating cholesterol metabolism destroy membrane integrity. also good biocompatibility superior antitumor activity no observable tissue damage.

Language: Английский

Citations

0
Excessive glutathione intake contributes to chemotherapy resistance in breast cancer: a propensity score matching analysis DOI Creative Commons
Zhiyuan Zhang, Jian Gao,

Linjiao Jia

et al.

World Journal of Surgical Oncology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 21, 2024

We aim to explore the impact of excessive glutathione (GSH) intake on chemotherapy sensitivity in breast cancer. Clinicopathological data were collected from 460 cancer patients who underwent adjuvant January 2016 December 2019 Zhengzhou University People's Hospital. The clinicopathological characteristics following GSH treatment and compared with those Non-GSH group after 1:2 propensity score matching (PSM). Intracellular levels expression antioxidant enzymes (NRF2, GPX4 SOD1) evaluated tumor tissues 51 receiving neoadjuvant chemotherapy. recurrence rate was significantly higher (n = 28, 31.8%) than that 39, 22.2%; P 0.010). Additionally, HGSH (high intake, ≥ 16 days) exhibited an elevated LGSH (low < 15 (46.8%) vs. n 52 (22.4%); 0.003). Cox regression revealed High Ki67 30%, Triple negative Lymphovascular invasion independent risk factors progression Among chemotherapy, intracellular resistant substantially (P 0.001). Excessive may contribute resistance cancer, are indicating standardization assist reducing resistance.

Language: Английский

Citations

0