Understanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review

Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)

Published: Dec. 23, 2024

Obesity is a multifactorial condition influenced by genetic, environmental, and microbiome-related factors. The gut microbiome plays vital role in maintaining intestinal health, increasing mucus creation, helping the epithelium mend, regulating short-chain fatty acid (SCFA) production. These tasks are for managing metabolism energy balance. Dysbiosis—an imbalance microbiome—leads to increased appetite rise of metabolic disorders, both fuel obesity its issues. Furthermore, childhood connects with unique shifts microbiota makeup. For instance, there surge pro-inflammatory bacteria compared children who not obese. Considering intricate nature variety microbiota, additional investigations necessary clarify exact involvement beginnings advancement related dilemmas. Currently, therapeutic methods like probiotics, prebiotics, synbiotics, fecal transplantation (FMT), dietary interventions Mediterranean ketogenic diets, physical activity show potential adjusting fight aid weight loss. review underscores integration microbial metabolites pharmacological agents such as orlistat semaglutide restoring homeostasis. However, more clinical tests essential refine doses, frequency, lasting effectiveness these treatments. This narrative overview compiles existing knowledge on multifaceted much more, showcasing possible treatment strategies addressing health challenges.

Language: Английский

Enhancing Bone Health with Conjugated Linoleic Acid: Mechanisms, Challenges, and Innovative Strategies

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1395 - 1395

Published: April 21, 2025

Conjugated linoleic acid (CLA) is a bioactive compound known for its anti-inflammatory, anti-carcinogenic, and metabolic effects, with growing interest in role supporting bone health. Preclinical studies, particularly those involving the t10c12 isomer, have shown that CLA can enhance mineral density (BMD) by enhancing formation reducing resorption, indicating potential as therapeutic agent to improve However, clinical trials yielded inconsistent results, underscoring difficulty translating animal model successes human applications. A major challenge CLA’s low water solubility, poor absorption, limited bioavailability, which restrict effectiveness. To address these issues, nanoparticle-based delivery systems been proposed stability, resistance oxidative damage, thereby bioactivity. Recent studies also suggest electrical stimulation stimulate regeneration promoting cell proliferation, differentiation, adherence scaffolds. This review explores combined use of supplementation novel approach improving health, osteoporosis management. By integrating biological effects regenerative stimulation, this multimodal strategy offers promising method restoration, significant implications applications

Language: Английский

Pulmonary delivery of magnolol-loaded nanostructured lipid carriers for COPD treatment

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124495 - 124495

Published: July 24, 2024

Language: Английский